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Evidence Against D2 Dopaminergic Influence on Phosphoinosotde Metabolism in Pituitary and Neural Cells

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Book cover Neuroendocrine Perspectives

Part of the book series: Neuroendocrine Perspectives ((NEUROENDOCRINE,volume 6))

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Abstract

Prolactin secretion from the adenohypophysis is known to be under the tonic inhibitory control of the hypothalamus. Dopamine (DA) is believed to be the major inhibitory influence, being released from tuberoinfundibular dopaminergic neurons and transported to the pituitary gland via the hypophysial portal vessels. High affinity saturable and stereoselective DA receptors have been identified in adenohypophysial homogenates (see refs. 1–3); these have been characterized as the D2 type (4). Immunostaining has shown these receptors to be located on the lactotrophs (5). While there is considerable evidence from our group and others to show that dopamine can reduce intracellular cyclic AMP (cAMP) levels in adenohypophysial cells (see refs. 6,7), this cannot fully account for the observed inhibition of prolactin secretion, nor its mechanism.

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Authors and Affiliations

  1. Department of Human Metabolism & Clinical Biochemistry, University of Sheffield Medical School, Sheffield, England, UK

    J. G. Baird, B. L. Brown & P. R. M. Dobson

Authors
  1. J. G. Baird
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  2. A. B. Cubitt
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  3. B. L. Brown
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  4. P. R. M. Dobson
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Editor information

Editors and Affiliations

  1. Department of Endocrinology, St. Bartholomew’s Hospital, EC1A 7BE, London, UK

    John A. H. Wass

  2. Department of Medicine, University of Wales College of Medicine, CF4 4XN, Cardiff, UK

    Maurice F. Scanlon

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© 1989 Springer-Verlag New York Inc.

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Baird, J.G., Cubitt, A.B., Brown, B.L., Dobson, P.R.M. (1989). Evidence Against D2 Dopaminergic Influence on Phosphoinosotde Metabolism in Pituitary and Neural Cells. In: Wass, J.A.H., Scanlon, M.F. (eds) Neuroendocrine Perspectives. Neuroendocrine Perspectives, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3478-4_18

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  • DOI: https://doi.org/10.1007/978-1-4612-3478-4_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8117-7

  • Online ISBN: 978-1-4612-3478-4

  • eBook Packages: Springer Book Archive

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