Abstract
Our early attempts to understand the role of the lung epithelium in the pathophysiology of lung edema and alveolar flooding were hampered by a lack of techniques for specifically assessing changes in lung epithelial permeability to proteins. Consequently, we have developed two methods for assessing solute exchange across the lung epithelium: 1) the use of nuclear imaging techniques to measure the rate of clearance of aerosolized 99mTc-labeled tracers from the air spaces of the lungs, and 2) the analysis of the clearance of these tracers via the lung lymphatics. Both of these methods employ mathematical modeling techniques to obtain the maximum amount of information from the data.
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References
Gee, M.H., and N.C. Staub. Role of bulk fluid flow in protein permeability of the dog lung alveolar membrane. J. Appl. Physiol. 42:144–149,1977.
Marks, J.D., J.M. Luce, N.M. Lazar, J. Ngao-Sun Wu, A. Lipavsky, and J.F. Murray. Effect of increases in lung volume on clearance of aerosolized solute from human lungs. J. Appl. Physiol. 59: 1242–1248,1985.
Peterson, B.T, T.R. Harris, and K.L. Brigham. Comparison of sodium and urea as indicators of pulmonary vascular permeability. Exp. Lung Res. 4: 79–92,1983.
Peterson, B.T., and L.D. Gray. Pulmonary lymphatic clearance of 99mTc-DTPA from air spaces during lung inflation and lung injury. J. Appl. Physiol. 63:1136–1141,1987.
Peterson, B.T., H.L. James, and J.W. McLarty. Effects of lung volume on clearance of solutes from the air spaces of lungs. J. Appl. Physiol. 64: 1068–1075,1988.
Peterson, B.T., M.L. Collins, and A.O. Azghani. Aerosolized Pseudomonas elastase increases lung epithelial permeability to albumin in anesthetized sheep. Am. Rev. Respir. Dis. 139: A294,1989 (Abstract).
Peterson, B.T. Pulmonary clearance of aerosolized 99mTc-DTPA and the lung epithelium. J. Aerosol Medicine 2: 315–328,1989.
Peterson, B.T., K.D. Dickerson, H.L. James, E.J. Miller, J.W. McLarty, and D.B. Holiday. Comparison of three tracers for detecting lung epithelial injury in anesthetized sheep. J. Appl. Physiol. 66: 2374–2383,1990.
Peterson, B.T. and K.D. Dickerson. Concentration of aerosolized 99mTc-albumin in the pulmonary lymph of anesthetized sheep. J. Appl. Physiol. 68:1233–1240,1990.
Peterson, B.T., M.L. Collins, L.D. Gray, and D. Suez. Effect of aerosol size on the clearance of DTPA from lungs of anesthetized sheep. J. Aerosol Medicine. In Press.
Rinderknecht, J., L. Shapiro, M. Krauthammer, G. Taplin, K. Wasserman, J.M. Uszler, and R.M. Effros. Accelerated clearance of small solutes from the lungs in interstitial lung disease. Am. Rev. Respir. Dis. 121: 105–117, 1980.
Taylor, A.E., and K.A. Gaar. Estimation of equivalent pore radii of pulmonary capillary and alveolar membranes. Am. J. Physiol. 218: 1133–1140, 1970.
Vaughn, T.R., Jr., A.J. Erdman III, K.L. Brigham, W.C. Woolverton, W.J Weidner, and N.C. Staub. Equilibration of intravascular albumin with lung lymph in unanesthetized sheep. Lymphology 12: 217–223,1979.
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© 1990 Springer-Verlag New York, Inc.
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Peterson, B.T., Collins, M.L., Connelly, J.C., McLarty, J.W., Holiday, D., Gray, L.D. (1990). Use of Mathematics in Assessing Solute Exchange Across the Lung Epithelium. In: Epstein, M.A.F., Ligas, J.R. (eds) Respiratory Biomechanics. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3452-4_20
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DOI: https://doi.org/10.1007/978-1-4612-3452-4_20
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