Abstract
Phencyclidine (PCP) was synthesized in 1957 by Parke-Davis Laboratories and shortly afterwards was entered into clinical trials under the brand name of Sernyl. It was originally intended to be the perfect intravenous, surgical anes-thetic and did not, in fact, depress respiratory and cardiovascular functions. However, 10 to 20 percent of the patients to which it was administered exhibited bizarre postoperative behavior, including extreme agitation, delirium, muscle rigidity and seizures.1–3 Because of this, PCP was removed from the market for use as a human anesthetic in 1965. Ketamine (Ketalar), a shorter-acting homolog with fewer side effects, replaced PCP as a dissociative anesthetic for humans and is still used today.4 PCP continued to be manufactured and marketed from 1965 to 1978 as a veterinary anesthetic, Sernylan. In 1979 all legal manufacture of PCP ceased. It was placed in Class II by the Drug Enforcement Administration (DEA) in 1970.2,5–6
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Milhorn, H.T. (1990). Phencyclidines. In: Chemical Dependence. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3418-0_17
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