Human Placental Adenosine A2-Like Binding Sites Properties and Homology with Mammalian and Avian Stress Proteins
Adenosine is a biologically active compound at two cell surface receptors, the adenosine A1 and the adenosine A2 receptors. The adenosine A1 receptor has been labeled and characterized with selective adenosine analogs. The adenosine A2 receptor has been labeled using N-ethylcarboxamidoadenosine (NECA). However, in most tissues the majority of definable specific NECA binding is to the ubiquitous adenosine A2-like binding sites which has properties that distinguish it from the adenosine A2 receptor (Lohse et al., 1988). One of the major differences in binding relates to the high affinity binding of N6 substituted adenosine analogs and C8 substituted xanthines to the adenosine A2 receptor and the lack of binding of these compounds to the adenosine A2-like binding site.
KeywordsPartial Specific Volume Adenosine Analog Placental Membrane Stokes Radius Tumor Rejection Antigen
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