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Tachykininergic Axons in the Guinea Pig Carotid Body: Origin, Ultrastructure, and Coexistence with Other Peptides

  • W. Kummer
  • A. Fischer
Conference paper

Abstract

Several peptides of the tachykinin family, substance P (SP), neurokinin A (NKA), and neuropeptide K are present in subpopulations of primary afferent neurons. SP-like immunoreactive (SP-LI) nerve fibers have been observed in the carotid body of many species (1–5) and it has been hypothesized that these axons represent the chemoreceptor afferents (4). This interpretation, however, generally, is not accepted (5), and, in fact, even the exact origin of SP-LI nerve fibres innervating the carotid body is unknown. Degeneration experiments revealed that, in the guinea pig, the bulk of SP-LI fibers is supplied via the carotid sinus nerve (CSN) to the carotid body (3). Extending this investigation, the present study was aimed to determine origin, ultrastructure, and coexisting peptides of these fibers.

Keywords

Carotid Body Glomus Cell Carotid Sinus Nerve Polyclonal Seron Arterial Chemoreception 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • W. Kummer
  • A. Fischer

There are no affiliations available

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