Effects of Different Stimuli and Transmitters on Glomus Cell Membranes and Intercellular Communications

  • L. Monti-Bloch
  • C. Eyzaguirre
Conference paper


The carotid body glomus cells appear to be the site for chemotransduction in this receptor, although this point is not entirely settled. In any event, these cells constitute the bulk of the organ containing and releasing several neurotransmitters: acetylcholine (ACh); catecholamines, especially dopamine (DA); and neuropeptides (enkephalins, substance P) as discussed by other authors in this volume. Therefore, they constitute primary investigative targets to learn about their membrane properties and possible changes occurring in response to different stimuli and transmitters that modulate the carotid nerve discharge.


Lactic Acid Carotid Body Intercellular Communication Voltage Noise Glomus Cell 
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  1. 1.
    Baron M, Eyzaguirre C (1977). Effects of temperature on some membrane characteristics of carotid body cells. Am J Physiol Cell Physiol 2: C35 - C46.Google Scholar
  2. 2.
    Bennet MVL (1966). Physiology of electrotonic junctions. Ann NY Acad Sci 137: 509–539.CrossRefGoogle Scholar
  3. 3.
    Eyzaguirre C, Monti Bloch L, Baron M, Hayashida Y, Woodbury, JW (1989). Changes in glomus cell membrane properties in response to stimulants and depressants of carotid nerve discharge. Brain Res 477: 265–279.PubMedCrossRefGoogle Scholar
  4. 4.
    Eyzaguirre C, Monti Bloch L, Woodbury JW (1990). Effects of putative neurotransmitters of the carotid body on its own glomus cells. Eur J Neurosci 2: 7788, 1990.Google Scholar
  5. 5.
    Verna A (1979). Ultrastructure of the carotid body in the mammals. Int Rev Cytol 60: 271–330.PubMedCrossRefGoogle Scholar
  6. 6.
    Oyama, Y, Walker JL, Eyzaguirre C (1986a). The intracellular chloride activity of glomus cells in the isolated rabbit carotid body. Brain Res 368: 167–169.PubMedCrossRefGoogle Scholar
  7. 7.
    Oyama Y, Walker JL, Eyzaguirre C (1986b). Intracellular potassium activity, potassium equilibrium potential and membrane potential of carotid body glomus cells. Brain Res 381: 405–408.PubMedCrossRefGoogle Scholar
  8. 8.
    McDonald DM (1981). Peripheral chemoreceptors: structure-function relationships of the carotid body. In: Hornbein TF (Ed). Regulation of Breathing Marcel Decker: New York, pp 105–320.Google Scholar
  9. 9.
    Hayashida Y, Eyzaguirre C (1979). Voltage noise of carotid body type I cells. Brain Res 167: 189–194.PubMedCrossRefGoogle Scholar
  10. 10.
    Eyzaguirre C, Fitzgerald RS, Lahiri S, Zapata P (1983). Arterial chemoreceptors. In: Handbook of Physiology. The Cardiovascular System Vol III Sect 2, Am Physiol Soc, Bethesda, MD, pp 557–621.Google Scholar
  11. 11.
    Eyzaguirre C, Monti Bloch L (1982). Nicotinic and muscarinic reactive sites in mammalian glomus cells. Brain Res 252: 181–184.PubMedCrossRefGoogle Scholar
  12. 12.
    Fidone SJ, Gonzalez C (1986). Initiation and control of chemoreceptor activity in the carotid body. In: Handbook of Physiology. The Respiratory System Vol II, Sect 3, Am Physiol Soc, Bethesda, MD, pp 247–312.Google Scholar
  13. 13.
    Goldman WF, Eyzaguirre C (1984). The effect of dopamine on glomus cell membranes in the rabbit. Brain Res 321: 337–340.PubMedCrossRefGoogle Scholar
  14. 14.
    Hille B (1984). Ionic Channels of Excitable Membranes Sunderland, Sinauer, MA, pp. 426.Google Scholar
  15. 15.
    López-Barneo J, López-López JR, Urena J, Gonzalez C (1988). Chemotransduction in the carotid body: K+ current modulated by PO, in type I chemoreceptor cells. Science 24: 580–582.Google Scholar
  16. 16.
    Monti-Bloch L, Eyzaguirre C (1980). A comparative physiological and pharmacological study of cat and rabbit carotid body chemoreceptors. Brain Res 193: 449–470.PubMedCrossRefGoogle Scholar
  17. 17.
    Dinger B, Gonzalez C, Yoshizaki K, Fidone S (1985). Localization and function of cat carotid body nicotinic receptors. Brain Res 339: 295–304.PubMedCrossRefGoogle Scholar
  18. 18.
    Dinger B, Hirano T, Fidone SJ (1986). Autoradiographic localization of muscarinic receptors in rabbit carotid body. Brain Res 367: 328–331.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • L. Monti-Bloch
  • C. Eyzaguirre

There are no affiliations available

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