Abstract
As early as 1913 Anitschkow (1) described the cells of the aortic intimal lesions of rabbits that had been eating food rich in cholesterol. In his drawings of lesions, Anitschkow pictured both smooth muscle cells and macrophages. Some of the macrophage foam cells are pictured in mitosis, and lesion smooth muscle cells are described as modified (equivalent to the terms RER-rich or synthetic). His observations, although limited by the methods of his time, remain nevertheless valid not only for experimental atherosclerotic lesions, but also for human lesions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anitschkow N (1913) Uber die veranderungen der kaninchenaorta bei experimenteller cholesterinsteatose. Beit path Anat Allgem Pathol 56:379–404
Kocher O, Gabbiani G (1986) Cytoskeletal features of normal and atheromatous human arterial smooth muscle cells. Hum Pathol,. 17: 875–880
Gerrity RG, Goss JA, Soby L (1985) Control of monocyte recruitment by chemotactic factor(s) in lesion-prone areas of swine aorta. Arteriosclerosis 5:55–66
Stary HC (1987) Macrophages, macrophage foam cells, and eccentric intimal thickening in the coronary artery intima of young children. Atherosclerosis 64:91–108
Stary HC (1987) Evolution and progression of atherosclerosis in the coronary arteries of children and adults. In: Bates RS, Gangloff EC (eds) Atherogenesis and Aging, Springer-Verlag, New York, pp 20–36
World Health Organization (1958) Classification of atherosclerotic lesions. Report of a study group. WHO Techn Rep Ser 143, pp 1–20
Guzman MA, McMahan CA, McGill HC Jr, Strong JP, Tejada C, Restrepo C, Eggen DA, Robertson WB, Solberg LA (1968) Selected methodologic aspects of the international atherosclerosis project. Lab Invest 18:479–497
Katz SS, Shipley GG, Small DM (1976) Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques. J Clin Invest 58:200–211
Naumann A, Schmid-Schonbein H (1983) A fluid-dynamicist’s and a physiologist’s look at arterial flow and arteriosclerosis. In: Schettler G <Emphasis FontCategory=“NonProportional”>et al</Emphasis> (eds) Fluid dynamics as a localizing factor for atherosclerosis. Springer-Verlag, Berlin Heidelberg, pp 9–25
Constantinides P (1984) Ultrastructural pathobiology. Elsevier, Amsterdam, p 110
Daoud AS, Jormolych J, Augustyn JM, Fritz KE (1981) Sequential morphologic studies of regression of advanced atherosclerosis. Arch Pathol Lab Med 105:233–239
Bocan TMA, Schifani TA, Guyton JR (1986) Ultrastructure of the human aortic fibrolipid lesion. Formation of the atherosclerotic lipid-rich core. Am J Pathol 123:413–424
Bowden DH (1983) Cell turnover in the lung. Am Rev Respir Dis 128:S46–S48
van Furth R (1985) Cellular biology of pulmonary macrophages. Int Archs Allergy Appl Immun 76 (suppl 1):21–27
Stary HC (1979) Regression of atherosclerosis in primates. Virchows Arch A (Path Anat) 383:117–134
Stary HC (1974) Proliferation of arterial cells in atherosclerosis. In: Wagner WD, Clarkson TB (eds) Arterial Mesenchyme and Arteriosclerosis. Adv Exp Med Biol 43:59–81, Plenum Press, New York
Wissler RW (1967) The arterial medial cell, smooth muscle, or multifunctional mesenchyme? Circulation 36:1–4
Ross R, Wight TN, Strandness E, Thiele B (1984) Human Atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery. Am J Pathol 114:79–93
Feigl W, Susani M, Ulrich W, Matejka M, Losert U, Sinzinger H (1985) Organisation of experimental thrombosis by blood cells. Virchows Arch A (Path Anat) 406:133–148
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag New York Inc.
About this paper
Cite this paper
Stary, H.C. (1990). Changes in the Cells of Atherosclerotic Lesions as Advanced Lesions Evolve in Coronary Arteries of Children and Young Adults. In: Glagov, S., Newman, W.P., Schaffer, S.A. (eds) Pathobiology of the Human Atherosclerotic Plaque. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3326-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3326-8_6
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7968-6
Online ISBN: 978-1-4612-3326-8
eBook Packages: Springer Book Archive