Skip to main content
SpringerLink
Log in

Atherosclerosis of Saphenous Vein Coronary Artery Bypass Grafts in Relation to Risk Factors

  • Conference paper
Pathobiology of the Human Atherosclerotic Plaque

  • 101 Accesses

Abstract

Atherosclerosis of saphenous vein coronary artery bypass grafts is now recognized as a frequent complication (1–7). It is rarely observed during the first postoperative years (1,8,9), but its prevalence increases progressively thereafter. The angiographic diagnosis of these atherosclerotic lesions is based primarily on their late development after the first postoperative year (2,3). The atherosclerotic nature of these lesions has been confirmed on pathology examination by the presence of foam cells and lipid deposits, as well as by classic macroscopic aspects (1,7,10–17).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lie JT, Lawrie GM, Morris GC Jr (1977) Aortocoronary bypass saphenous vein graft atherosclerosis. Anatomic study of 99 vein grafts from normal and hyperlipoproteinemic patients up to 75 months postoperatively. Am J Cardiol 40:906–914.

    Article  PubMed  CAS  Google Scholar 

  2. Palac RT, Meadows WR, Hwang MH, Loeb HS, Pifarre R, Gunnar RM (1982) Risk factors related to progressive narrowing in aortocoronary vein grafts studied 1 and 5 years after surgery. Circulation 66 (Suppl I):I-40–I-44.

    Google Scholar 

  3. Campeau L, Enjalberg M, Lesperance J, Vaislic C, Grondin CM, Bourassa MG (1983) Atherosclerosis and late closure of aortocoronary saphenous vein grafts: Sequential angiographic studies at 2 weeks, 1 year, 5 to 7 years, and 10 to 12 years after surgery. Circulation 68 (Suppl II): II-1–II-7.

    Google Scholar 

  4. Lytle BW, Loop FD, Cosgrove DM, Ratliff NB, Easley K, Taylor PC (1985) Long-term (5 to 12 years) serial studies of internal mammary artery and saphenous vein coronary bypass grafts. J Thorac Cardiovasc Surg 89: 248–258.

    PubMed  CAS  Google Scholar 

  5. Fitzgibbon GM, Leach AJ, Keon WJ, Burton JR, Kafka HP (1986) Coronary bypass fate. Angiographic study of 1,179 vein grafts early, one year, and five years after operation. J Thorac Cardiovasc Surg 91:773–778.

    PubMed  CAS  Google Scholar 

  6. Atkinson JB, Forman MB, Vaughn WK, Robinovitz, M, McAllister HA, Virmani R (1985) Morphologic changes in long-term saphenous vein bypass grafts. Chest 88:341–348.

    Article  PubMed  CAS  Google Scholar 

  7. Neitzel GF, Barboriak JJ, Pintar K, Qureshi I (1986) Atherosclerosis in aortocoronary bypass grafts. Morphologic study and risk factor analysis 6 to 12 years after surgery. Arteriosclerosis 6:594–600.

    Article  PubMed  CAS  Google Scholar 

  8. Solymoss BC, Campeau L, Grondin CM (1979) Morphologic alterations in aortocoronary vein grafts in place for up to eight years. Exc Med Amsterdam Intern Congress Series 491:889.

    Google Scholar 

  9. Smith SH, Geer JC (1981) Morphology of saphenous vein-coronary artery bypass grafts 7 months to 8 years postoperatively. Circulation 64 (Suppl IV):IV–90 (abstract).

    Google Scholar 

  10. Loop FD, Lytle BW, Gill CC, Golding LAR, Cosgrove DM, Taylor PC (1983) Trends in selection and results of coronary artery reoperations. Ann Thorac Surg 36: 380–388.

    Article  PubMed  CAS  Google Scholar 

  11. Marshall WG Jr, Saffitz J, Kouchoukos NT (1986) Management during reoperation of aortocoronary saphenous vein grafts with minimal atherosclerosis by angiography. Ann Thorac Surg 42:16 3–167.

    Google Scholar 

  12. Brynjolfsson G (1972) Pathologic changes in venous coronary bypasses. Proc Inst Med Chic 29:79–80 (abstract).

    PubMed  CAS  Google Scholar 

  13. Barboriak JJ, Batayias GE, Pintar K, Tieu TM, Van Horn DL, Korns ME (1972) Late lesions in aorta-coronary artery vein grafts. J Thorac Cardiovasc Surg 64:596–601.

    Google Scholar 

  14. Kern WH, Dermer GB, Lindensmith GG (1972) The intimal proliferation in aortic-coronary saphenous vein grafts. Am Heart J 84:771–777.

    Article  PubMed  CAS  Google Scholar 

  15. Bulkley BH, Hutchins GM (1977) Accelerated “atherosclerosis”. A morphologic study of 97 saphenous vein coronary artery bypass grafts. Circulation 55:163–169.

    PubMed  CAS  Google Scholar 

  16. Unni KK, Kottke BA, Titus JL, Frye RL, Wallace RB, Brown AL (1974) Pathologic changes in aortocoronary saphenous vein grafts. Am J Cardiol 34:526–532.

    Article  PubMed  CAS  Google Scholar 

  17. Klima T, Beard EF, Milan JD, Reul CJ Jr, Cooley DA (1979) Atherosclerosis of aortocoronary artery saphenous vein bypass grafts. Cardiovascular Diseases, Bulletin of the Texas Heart Institute 6:318–323.

    PubMed  Google Scholar 

  18. Doyle JT (1972) Cigarette smoking and coronary atherosclerosis. In: Likoff W, Segal BL, Insull W (eds) Atherosclerosis and Coronary Heart Disease. New York: Grune and Stratton, p. 35.

    Google Scholar 

  19. Epstein FH (1967) Hyperglycermia, a risk factor in coronary heart disease. Circulation 36:609.

    PubMed  CAS  Google Scholar 

  20. Freis ED (1969) Hypertension and atherosclerosis. Am J Med 46:735.

    Article  PubMed  CAS  Google Scholar 

  21. Epstein FH (1969) Hereditary aspects of coronary heart disease. Am J Med 46:735.

    Article  Google Scholar 

  22. Kannel WB, Castelli WP, Gordon T, McNamara PM (1971) Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham Study. Ann Intern Med 74:1.

    PubMed  CAS  Google Scholar 

  23. Gordon T, Castelli WP. Hjortland MC et al. (1977) High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 62:707.

    Google Scholar 

  24. Roberts WC, Ferrans VJ, Levy RI, Fredrickson DS (1973) Cardiovascular pathology in hyperlipoproteinemia. Anatomic observations in 42 necropsy patients with normal or abnormal serum lipoprotein patterns. Am J Cardiol 31:557.

    Article  PubMed  CAS  Google Scholar 

  25. Campeau L, Enjalbert M, Lesperance J, Bourassa MG, Kwiterovich P, Wacholer S, Sniderman A (1984) The relation of factors to the development of atherosclerosis in saphenous vein bypass grafts and the progression of disease in the native circulation. N Engl J Med 311:1329–1332.

    Article  PubMed  CAS  Google Scholar 

  26. Sniderman A, Teng B, Jerry M (1975) Determination of B protein of low density lipoprotein directly in plasma. J Lipid Res 16:465–467.

    PubMed  CAS  Google Scholar 

  27. Siedel J, Schlumberger H, Klose S, Ziegenhorn J, Wahlefeld AW (1981) Improved reagent for the enzymatic determination of serum cholesterol. J Clin Chem Clin Biochem 19:838.

    Google Scholar 

  28. Sampson EJ, Demers LM, Krein AF (1975) Faster enzymatic procedure for serum triglycerides. Clin Chem 21:1983–1985.

    PubMed  CAS  Google Scholar 

  29. Warnick GR, Benderson J, Albers JJ, Baillie EE, Sexton B, Schaefer EJ, Carlson D, Hill M, Brewer HB, Wiebe DA, Hazlehurst J, Cooper GR (1982) Dextran Sulfate-Mg2+ precipitation for quantitation of high-density-lipoprotein cholesterol. Clin Chem 28:1379–1388.

    PubMed  CAS  Google Scholar 

  30. Enjalbert M, Campeau L, Lesperance J, Grondin CM, Bourassa MG (1984) Angiographic features of saphenous vein aortocoronary bypass graft atherosclerosis. J Am Coll Cardiol 3:529 (abstract).

    Google Scholar 

  31. Larson RM, Hagen PO, Fuchs JCA (1974) Lipid biosynthesis in arteries, veins and venous grafts. Circulation 50 (Suppl 3):529 (abstract).

    Google Scholar 

  32. Sako Y (1961) Susceptibility of autologous vein grafts to atheromatous degeneration. Surg Forum 12:247–249.

    PubMed  CAS  Google Scholar 

  33. Friedman M (1963) Spontaneous atherosclerosis and exerpimental thrombo-atherosclerosis Arch Pathol 76:571–577.

    CAS  Google Scholar 

  34. Scott HW Jr, Morgan CV, Bolasny BL, Lanier VC, Younger RK, Butts W (1970) Experimental atherosclerosis in autogenous venous grafts. Arch Surg 101:677–682.

    PubMed  Google Scholar 

  35. King P, Boyle JP (1972) Autogenous vein grafting in atheromatous rabbits. Cardiovasc Res 6:627–633.

    Article  PubMed  CAS  Google Scholar 

  36. Ross R, Giomset JA (1973) Atherosclerosis and the arterial smooth muscle cell. Proliferation of smooth muscle cell is a key event in the genesis of the lesions of atherosclerosis. Science 180:1332.

    Article  PubMed  CAS  Google Scholar 

  37. Lawrie GM, Lie JT, Morris GC Jr, Beazley HL (1976) Vein graft patency and intimal proliferation after aortocoronary bypass: Early and long-term angiopathologic correlations. Am J Cardiol 38:856–862.

    Article  PubMed  CAS  Google Scholar 

  38. Lesperance J, Bourassa MG, Saltiel J, Campeau L, Grondin CM (1973) Angiographic changes in aortocoronary vein grafts. Lack of progression beyond the first year. Circulation 48:633–643.

    PubMed  CAS  Google Scholar 

  39. World Health Organization (1958) Classification of atherosclerotic lesions: Report of a study group. Technical Report Series. Publication 143. Geneva: World Health Organization, pp. 3–20.

    Google Scholar 

  40. Batayias GE, Barboriak JJ, Korns ME, Pintar K (1977) The spectrum of pathologic changes in aortocoronary saphenous vein grafts. Circulation 56 (suppl II):II-18–II-25.

    Google Scholar 

  41. Gunthaner DF, Robert EW, Alderman EL, Wexler L (1979) Long-term serial angiographic studies after coronary artery bypass surgery. Circulation 60:250–258.

    Google Scholar 

  42. Barner HB, Swartz MT, Mudd JG, Tyras DH (1982) Late patency of the internal mammary artery as a coronary bypass conduit. Ann Thorac Surg 34:408–412.

    Article  PubMed  CAS  Google Scholar 

  43. Kouchoukos NT, Karp RB, Oberman A, Russell RO Jr, Alison HW, Holt JH (1978) Long-term patency of saphenous veins for coronary bypass grafting. Cardiovascular Surgery, 1977 Supp. to Circulation 58 (Suppl I):I-96–I-99.

    Google Scholar 

  44. Seides SF, Borer JS, Kent KM, Rosing DR, McIntosh CL, Epstein SE (1978) Long-term anatomic fate of coronary-artery bypass grafts and functional status of patients five years after operation. N Engl J Med 298:1213–1217.

    Article  PubMed  CAS  Google Scholar 

  45. Campeau L, Lesperance J, Corbara F, Hermann J, Grondin CM, Bourassa MG (1978) Aortocoronary saphenous vein bypass graft changes 5 to 7 years after surgery. Cardiovascular Surgery, 1977. Supp. to Circulation 58 (Suppl I) I-170–I-175.

    Google Scholar 

  46. Rossiter SJ, Brody WR, Kosek JC, Lipton MJ, Angell WW (1974) Internal mammary artery versus autogenous vein for coronary bypass graft. Circulation 50:1236–1243.

    PubMed  CAS  Google Scholar 

  47. Solymoss BC, Nadeau P, Campeau L (1987) Factors related to atherosclerosis of saphenous vein coronary bypass grafts. J Am Coll Cardiol 9:85A.

    Google Scholar 

  48. Lawrie GM, Morris GC Jr, Thomas S, Glaeser D (1986) Influence of cholesterol on late graft patency in 322 patients followed up to 14 years after coronary bypass. J Am Coll Cardiol 7:142A.

    Google Scholar 

  49. Grondin CM, Campeau L, Lesperance J, Solymoss BC, Vouhe P, Castonguay YR, Meere C, Bourassa MG (1979) Atherosclerotic changes in coronary vein grafts six years after operation. J Thorac Cardiovasc Surg 77:25–31.

    Google Scholar 

Download references

Authors
  1. Lucien Campeau
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Parise Nadeau
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Charles Solymoss
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The University of Chicago Hospital, Chicago, Illinois, 60637, USA

    Seymour Glagov MD (Professor of Pathology) (Professor of Pathology)

  2. Department of Pathology, Louisiana State University, New Orleans, Louisiana, 70112-1393, USA

    William P. Newman III MD

  3. Colestech Corporation, Hayward, California, 94545, USA

    Sheldon A. Schaffer PhD

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag New York Inc.

About this paper

Cite this paper

Campeau, L., Nadeau, P., Solymoss, B.C. (1990). Atherosclerosis of Saphenous Vein Coronary Artery Bypass Grafts in Relation to Risk Factors. In: Glagov, S., Newman, W.P., Schaffer, S.A. (eds) Pathobiology of the Human Atherosclerotic Plaque. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3326-8_41

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-3326-8_41

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7968-6

  • Online ISBN: 978-1-4612-3326-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation