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The Repetitive Plasma Exchange/Drug Trial in Familial Hypercholesterolemia: Very Early Results from Two-year Coronary Angiograms

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Pathobiology of the Human Atherosclerotic Plaque

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Abstract

Familial hypercholesterolemia (FH) is a dominantly inherited defect of low density lipoprotein (LDL) catabolism due to a defect in the LDL receptor activity. The disorder affects approximately one in 200 to one in 500 persons in North America (1). Thus, between 500,000 and 1,000,000 Americans are likely to be affected. The great majority of affected subjects are heterozygotes in whom the disorder is characterized by elevated LDL cholesterol, frequent appearance of xanthomata in early adult life, and the premature onset of coronary heart disease. In some studies, the risks of developing clinically evident coronary artery disease (CAD) in men with FH were 5% by age 30, while 80% of men were symptomatic by age 60 (2). The risks for CAD in females with the disorder is less but still very much higher than in the non-affected population.

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References

  1. Fredrickson DS, Levy RI (1972) Familial hyperlipoproteineima. In: Stanbury JB, Wyngaarden JB, Fredrickson DS (eds) The Metatolic Basis of Inherited Disease. 3rd Ed. New York: Mc-Graw-Hill, p. 546.

    Google Scholar 

  2. Slack J (1969) Risks of ischemic heart disease in familial hyperlipoproteinemic states. Lancet 2:1380.

    Article  PubMed  CAS  Google Scholar 

  3. Kane JP, Malloy MJ, Tun P, Phillips NR, Freedman DD, Williams ML, Rowe JS, Havel RJ (1981) Normalization of low density lipoprotein levels in heterozygous familial hypercholesterolemia with combined drug regimen. N Engl J Med 304:251.

    Article  PubMed  CAS  Google Scholar 

  4. Kuo PT, Kostis JB, Moreyra AE, Hayes JA (1981) Familial Type II hyperlipoproteinemia with coronary heart disease, effect of diet-colestipol-nicotinic acid treatment. Chest 79:286–291.

    Article  PubMed  CAS  Google Scholar 

  5. The Lovastatin Study Group II (1986) Therapeutic response to Lovastatin (mevinolin) in non-familial hypercholesterolemia: A multicenter study. JAMA 256:2829–2834.

    Article  Google Scholar 

  6. Vega GL, Grundy SM (1987) Treatment of primary moderate hypercholesterolemia with Lovastatin (mevinolin) and colestipol. JAMA 257:33–38.

    Article  PubMed  CAS  Google Scholar 

  7. Lees AM, Stein SW, Lees RS (1986) Therapy of hypercholesterolemia with mevinolin and other lipid lowering drugs. Arteriosclerosis 6:544a.

    Google Scholar 

  8. East CA, Bilheimer DW, Grundy (1986) Combination drug therapy for treatment of patients with familial combined hypertriglyceridemia and hypercholesterolemia. Arteriosclerosis 6:544a.

    Google Scholar 

  9. Thompson GR, Lowenthal R. Myant NB (1975) Plasma exchange in the management of homozygous familial hypercholesterolemia. Lancet 1:1208.

    Google Scholar 

  10. Stein EA, Glueck CJ, Wesselman A, Owens ER, Nichols S, Vink P (1981) Repatitive intermittent flow plasma exchange in patients with severe hypercholesterolemia. Atherosclerosis 38:149.

    Article  PubMed  CAS  Google Scholar 

  11. Lupien PJ, Moorjani S, Awad J (1976) A new approach to the management of familail hypercholesterolemia; Removal of plasma cholesterol based on the principle of affinity chromatography. Lancet 1:1261.

    Article  PubMed  CAS  Google Scholar 

  12. Burgstaler EA, Pineda AA, Ellefson RD (1980) Removal of plasma lipoproteins from circulating blood with a heparin-agarome column. Mayo Clin Proc 55:180–184.

    PubMed  CAS  Google Scholar 

  13. Yokoyama S, Hayashi R, Satani M, Yamamoto A (1985) Selective removal of low-density lipoprotein by plasmapheresis in familial hypercholesterolemia. Arteriosclerosis 5:613–622.

    Article  PubMed  CAS  Google Scholar 

  14. Leitman SF, Gregg RE, Adde MA, Smith JW (1986) Selective removal of low density lipoprotein (LDL) cholesterol by secondary membrane filtration. Transfusion 26:579.

    Google Scholar 

  15. Odaka M, Kobayashi H, Soeda K, et al. (1986) Adsorption of lipoprotein containing apolipoprotein B through plasma separation for treatment of familial hypercholesterolemia. Int J Artif 9; 343–348.

    CAS  Google Scholar 

  16. Bjork L, Spindola-Franco H, VanHouten FX, Cohn FP, Adams DF (1975) Comparison of observer performance with 16 mm cineflorography and 70 mm camera fluorography in coronary arteriography. Am J Cardiol 36: 473–478.

    Article  Google Scholar 

  17. Detre KM, Wright PH, Murphy ML, Takaro T (1975) Observer agreement in evaluating coronary angiograms. Circulation 52:979–986.

    PubMed  CAS  Google Scholar 

  18. Zir LM, Miller SW, Dinsmore RE, Gilbert JP, Harthorne JW (1976) Interobserver variability in coronary angiography. Circulation 53:627–632.

    PubMed  CAS  Google Scholar 

  19. DeRouen TA, Murray JA, Owen W (1977) Variability in the analysis of coronary angiograms. Circulation 55:324–328.

    PubMed  CAS  Google Scholar 

  20. Vlodaver Z, Frech R, Van Tassel RA, Edwards JE (1973) Correlation of the antemortem coronary arteriogram and the postmortem specimen. Circulation 4 7:162–169.

    Google Scholar 

  21. Grondin CM, Dryda I, Pasternac A, Campeau L, Bourassa MG, Lesperance J (1974) Discrepancies between cineangiographic and postmortem findings in patients with coronary disease and recent myocardial revascularization. Circulation 49:703–708.

    Google Scholar 

  22. Gallagher KP, Folts JD, Rowe GG (1978) Comparison of coronary arteriograms with direct measurements of stenosed coronary arteries in dogs. Am Heart J 95:338–347.

    Article  PubMed  CAS  Google Scholar 

  23. Hutchins GM, Bulkley BH, Ridolfe RL, Griffith LSC, Cohr FT, Piasio MA (1977) Correlation of coronary arteriograms and left ventriculograms with postmortem studies. Circulation 56:32–37.

    PubMed  CAS  Google Scholar 

  24. Myers MG, Shulman HS, Saibil EA, Nagri SZ (1978) Variations in measurement of coronary lesions on 35 and 70 mm angiograms. Am J Roentgenol 130:913–915.

    CAS  Google Scholar 

  25. Brown BG, Bolson E, Frimer M, Dodge HT (1977) Quantitative coronary arteriography: Estimation of dimensions, hemodynamic resistance, and atheroma mass of coronary artery lesions using the arteriogram and digital computation. Circulation 55:337.

    Google Scholar 

  26. McMahon MM, Brown BG, Cukingram R, Rolett EL, Bolson E, Frimir M, Dodge HT (1979) Quantitative coronary angiography: Measurement of the critical stenosis in patients with unstable angina and single vessel disease without collaterals. Circulation 60:106–113.

    PubMed  CAS  Google Scholar 

  27. Gould KL, Kelley KO, Bolson EL (1982) Experimental validation of quantitative coronary arteriography for determining pressure flow characteristics of coronary stenosis. Circulation 66:930–937.

    Article  PubMed  Google Scholar 

  28. Manual of Laboratory Operations, Lipid Research Clinics Program. Lipid and Lipoprotein Analysis. DHEW Publication No. (NIH) 1874:75–628.

    Google Scholar 

  29. Warnick GR, Albers JJ (1978) A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high-density lipoprotein cholesterol. J Lipid Res 19:65–73.

    PubMed  CAS  Google Scholar 

  30. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol without the use of the preparative ultracentrifuge. Clin Chem 18:499–502.

    PubMed  CAS  Google Scholar 

  31. Mendoza SG, Zerpa A, Carrasco H, et al. (1983) Estradiol, testosterone, apolipoproteins, lipoprotein cholesterol and lipolytic enzymes in men with premature myocardial infarction and angiographically assessed coronary occlusion. Artery 12:1–23.

    PubMed  CAS  Google Scholar 

  32. Stein EA, DiPersio L, Pesce AJ, et al. (1986) Enzyme-linked immunosorbant assay of apolipoproteins AII in plasma, with use of a monoclonal antibody. Clin Chem 32:967–971.

    PubMed  CAS  Google Scholar 

  33. Watson DD, Campbell NP, Read EK, Gibson RS, Teates CD, Beller GA (1981) Spatial and temporal quantitation of plane thallium myocardial images. J Nuclear Med 22:577–584.

    CAS  Google Scholar 

  34. Berger BC, Watson DD, Taylor GJ, Craddock GB, Martin RP, Teates CD, Beller GA (1981) Quantitative thallium-102 exercise scintigraphy for detection of coronary artery disease. J Nuclear Med 22:585–593.

    CAS  Google Scholar 

  35. Beller GA, Watson DD, Ackell P, et al. (1980) Time course and mechanism of thallium-201 redistribution after transient myocardial ischemia. Circulation 61: 791–796.

    PubMed  CAS  Google Scholar 

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Authors
  1. Evan A. Stein
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  2. Richard L. Kirkeeide
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  3. Lance Gould
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  4. Akira Nishikawa
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  5. Glenn Lamkin
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Editor information

Editors and Affiliations

  1. The University of Chicago Hospital, Chicago, Illinois, 60637, USA

    Seymour Glagov MD (Professor of Pathology) (Professor of Pathology)

  2. Department of Pathology, Louisiana State University, New Orleans, Louisiana, 70112-1393, USA

    William P. Newman III MD

  3. Colestech Corporation, Hayward, California, 94545, USA

    Sheldon A. Schaffer PhD

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© 1990 Springer-Verlag New York Inc.

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Stein, E.A., Kirkeeide, R.L., Gould, L., Nishikawa, A., Lamkin, G. (1990). The Repetitive Plasma Exchange/Drug Trial in Familial Hypercholesterolemia: Very Early Results from Two-year Coronary Angiograms. In: Glagov, S., Newman, W.P., Schaffer, S.A. (eds) Pathobiology of the Human Atherosclerotic Plaque. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3326-8_37

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  • DOI: https://doi.org/10.1007/978-1-4612-3326-8_37

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7968-6

  • Online ISBN: 978-1-4612-3326-8

  • eBook Packages: Springer Book Archive

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