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Lipoproteins and Pathogenesis of Atherosclerosis

  • Conference paper
Pathobiology of the Human Atherosclerotic Plaque

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Abstract

Let us start with the assumption that we all agree, along with the NIH Consensus Panel on Lowering Blood Cholesterol (1), that hypercholesterolemia in some way contributes importantly to the progress of human atherosclerosis. The question that remains to be answered is: How? Most investigators have assumed that hypercholesterolemia does its damage as a consequence of a high rate of delivery of cholesterol and other lipids into the artery wall. This is really just a restatement of the Virchow lipid infiltration hypothesis put forward about 100 years ago. However, even a casual look at a complicated human atherosclerotic lesion makes it clear that much more goes on than just the deposition of lipids. There are crucially important elements of cellular proliferation and accumulation of connective tissue matrix materials that contribute significantly to the ultimate stenosis of the vessel.

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Authors
  1. Daniel Steinberg
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Editor information

Editors and Affiliations

  1. The University of Chicago Hospital, Chicago, Illinois, 60637, USA

    Seymour Glagov MD (Professor of Pathology) (Professor of Pathology)

  2. Department of Pathology, Louisiana State University, New Orleans, Louisiana, 70112-1393, USA

    William P. Newman III MD

  3. Colestech Corporation, Hayward, California, 94545, USA

    Sheldon A. Schaffer PhD

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© 1990 Springer-Verlag New York Inc.

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Steinberg, D. (1990). Lipoproteins and Pathogenesis of Atherosclerosis. In: Glagov, S., Newman, W.P., Schaffer, S.A. (eds) Pathobiology of the Human Atherosclerotic Plaque. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3326-8_32

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  • DOI: https://doi.org/10.1007/978-1-4612-3326-8_32

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7968-6

  • Online ISBN: 978-1-4612-3326-8

  • eBook Packages: Springer Book Archive

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