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Nature and Importance of Proteoglycans in the Atherosclerotic Plaque

  • Conference paper
Pathobiology of the Human Atherosclerotic Plaque

Abstract

At the initial meeting on “Evolution of the Atherosclerotic Plaque” in 1963, the importance of specific glycosaminoglycans (GAG) (acid mucopolysaccharides) in atherosclerosis was shown (1). These complex sugars were noted to be an integral part of the arterial wall connective tissue matrix that changes with the type of atherosclerotic lesion. Although complex sugars were isolated from aorta about a century ago, it was not until the decade 1950–1960 (2) that characterization of the GAG fractions provided the opportunity to explore a pathobiologic role of these substances. Histochemical studies stimulated interest in complex sugars in atherosclerosis but did not allow their characterization. The considerable information that is now available from a variety of studies indicates that early in the formation of atherosclerotic lesions changes of GAG is part of the vascular connective tissue, followed by extensive lipid deposition and progression of lesions.

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Authors
  1. G. S. Berenson
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  2. B. Radhakrishnamurthy
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  3. S. R. Sinivasan
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  4. P. Vijayagopal
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  5. E. R. Dalferes Jr.
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Editor information

Editors and Affiliations

  1. The University of Chicago Hospital, Chicago, Illinois, 60637, USA

    Seymour Glagov MD (Professor of Pathology) (Professor of Pathology)

  2. Department of Pathology, Louisiana State University, New Orleans, Louisiana, 70112-1393, USA

    William P. Newman III MD

  3. Colestech Corporation, Hayward, California, 94545, USA

    Sheldon A. Schaffer PhD

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© 1990 Springer-Verlag New York Inc.

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Berenson, G.S., Radhakrishnamurthy, B., Sinivasan, S.R., Vijayagopal, P., Dalferes, E.R. (1990). Nature and Importance of Proteoglycans in the Atherosclerotic Plaque. In: Glagov, S., Newman, W.P., Schaffer, S.A. (eds) Pathobiology of the Human Atherosclerotic Plaque. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3326-8_13

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  • DOI: https://doi.org/10.1007/978-1-4612-3326-8_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7968-6

  • Online ISBN: 978-1-4612-3326-8

  • eBook Packages: Springer Book Archive

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