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Psychoneuroendocrinology pp 273–322Cite as

Congenital Hypothyroidism: Intellectual and Neuropsychological Functioning

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Abstract

Screening newborns for congenital hypothyroidism (CH) has been effective in preventing the mental retardation that typically occurred when diagnosis was based on clinical symptomatology. This chapter provides an overview of the disease and its manifestations as well as a comparison of outcome in children with CH diagnosed clinically with those now being found via newborn screening. A detailed description of the author’s own longitudinal study of screened CH children is also presented with special emphasis on the factors predicting better outcome.

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References

  • Abbasi, V., & Aldige, C. (1977). Evaluation of sodium L-thyroxine (TH) requirement in replacement therapy of hypothyroidism. Journal of Pediatrics, 90, 209–301.

    Google Scholar 

  • Addison, G.M., Rosenthal, M., & Price, D.A. (1989). Congenital hypothyroidism: Increased incidence in Asian families. (Abstract) In F. Delange, D.A. Fisher & D. Glinoer (Eds.) Research in Congenital Hypothyroidism New York: Plenum

    Google Scholar 

  • Alm, J., Larsson, A., & Zetterstrom, R. (1981). Congenital hypothyroidism in Sweden. Acta Paediatrica Scandinavica, 70, 907–912.

    Article  PubMed  Google Scholar 

  • American Academy of Pediatrics Committee on Genetics. American Thyroid Association Committee on Neonatal Screening (1987). Newborn screening for congenital hypothyroidism: Recommended guidelines. Pediatrics, 80, 745–749.

    Google Scholar 

  • Andersen, H.J. (1975). Hypothyroidism. In L.I. Gardner (Ed.), Endocrinology and Genetic Disease of Childhood. Philadelphia: W.B. Saunders Co.

    Google Scholar 

  • Antonozzi, I., Monaco, F., & Dominici, R. (1982). Regional differences in central and southern Italy in congenital hypothyroidism. In H. Naruse & M. Irie (Eds.), Neonatal screening (pp. 119–120). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Bainbridge, R., Mughal, Z., Mimouni, F., & Tsang, R.C. (1987). Transient congenital hypoparathyroidism: How transient is it? The Journal of Pediatrics, 111, 866–868.

    Article  PubMed  Google Scholar 

  • Balazs, R., Cocks, W.A., Eayrs, J.T., & Kovacs, S. (1971). Biochemical effects of thyroid hormones on the developing brain. In D.A. Hamburgh & E.J.W. Barrington (Eds.), Hormones in development. New York: Appleton-Century-Crofts.

    Google Scholar 

  • Barclay, R.A. (1981). Hyperactive children. A handbook for diagnosis and treatment. New York: Guilford.

    Google Scholar 

  • Bargagna, S., Cittadoni, L., Falciglia, G., Ferretti, G., Marcheschi, M., Chiovato, L., Giusti, F.L., Genzi, G.F. & Pinchera, A. (1989). Neuropsychological development of congenital hypothyroid children. (Abstract) In F.A. Delange, D.A. Fisher & D. Glinoer (Eds). Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Barnes, N.D. (1985). Screening for congenital hypothyroidism: The first decade. Archives of Disease in Childhood, 60, 587–592.

    Article  PubMed  Google Scholar 

  • Bode, H.H., Vanjonack, W.J., & Crawford, J.D. (1978). Mitigation of cretinism by breast-feeding. Pediatrics, 62, 13–16.

    PubMed  Google Scholar 

  • Bodegard, G., Fyro, K., & Larsson, A., (1983). Psychological reactions in 102 families with a newborn who has a falsely positive screening test for congenital hypothyroidism. Acta Paediatrica Scandinavica, 304, 1–21.

    Article  Google Scholar 

  • Brown, A.L., Fernhoff, P.M., Milner, J., McEwen, C., & Elsas, L.S. (1981). Racial differences in the incidence of congenital hypothyroidism. The Journal of Pediatrics, 99, 934–936.

    Article  PubMed  Google Scholar 

  • Browne, A.W., Bronstein, I.P., & Kraines, F. (1939). Hypothyroidism and cretinism in childhood: VI. Influence of thyroid therapy on mental growth. American Journal of Disease in Children, 57, 517–523.

    Google Scholar 

  • Burrow, B.N., & Dussault, J.H. (1980). Neonatal thyroid screening. New York: Raven Press.

    Google Scholar 

  • Burrow, G.N., Bachrach, L.A., & Holland, H. (1983). Maternal-fetal thyroid function. In H. Naruse & M. Irie (Eds.), Neonatal screening. Amsterdam: Excerpta Medica.

    Google Scholar 

  • Cheek, D.B. (1975). The fetus. In D.B. Cheek (Ed.), Fetal and postnatal cellular growth. Hormones and Nutrition. New York: Wiley & Sons.

    Google Scholar 

  • Chopra, I.J. (1972). A radioimmunoassay for measurement of thyroxine in unextracted serum. Journal of Clinical Endocrinological Metabolism, 34, 938–949.

    Article  Google Scholar 

  • Collipp, P.J., Kaplan, S.A., Kogut, M.D., Tasem, W., Plachte, F., Schlamm, V., Boyle, D.C., Ling, S.M., & Koch, R. (1965). Mental retardation in congenital hypothyroidim: improvement with thyroid replacement therapy. American Journal of Mental Deficiencies, 70, 432–437.

    Google Scholar 

  • Connelly, J. (1986). Congenital hypothyroidism. Australian Pediatrics Journal, 22, 165–166.

    Google Scholar 

  • Crome, L, & Stern, J. (1972). Pathology of mental retardation. Edinburgh: Churchill Livingston.

    Google Scholar 

  • David, M., Dorche, C., Coudier, J., Rolland, M.O. (1983). Follow up results of congenital hypothyroid infants found by neonatal screening. In H. Naruse & M. Irie (Eds.), Neonatal Screening. Amsterdam: Excerpta Medica.

    Google Scholar 

  • Davy, T., Daneman, D., Walfish, P.G., & Ehrlich, R.M. (1985). Congenital hypothyroidism: The effect of stopping treatment at 3 years. American Journal of Diseases in Childhood, 139, 1028–1030.

    Google Scholar 

  • DeGroot, L.J., Larsen, P.R., Refetoff, S., & Stanbury, J.B. (1984). Hypothyroidism in infants and children, and developmental abnormalities of the thyroid gland. In DeGroot (Ed.), The thyroid and its diseases (pp. 610–641).

    Google Scholar 

  • Delange, F., DeVijlder, J., Morreale de Escobar, G., Ruchiccioli, P., Varrone, S. (1989). Significance of early diagnostic data in congenital hypothyroidism. In F.A. Delange, D.A. Fisher, D. Glinoer (Eds.), Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Delange, F. (1980). Panel and general discussion: Optimal screening and recall procedures. In G.N. Burrow & J.H. Dussault, Neonatal thyroid screening. New York: Raven Press.

    Google Scholar 

  • Delange, F., Beckers, C., Hofer, R., Konig, M.P., Monaco, F., & Varrone, S. (1979). Neonatal screening for congenital hypothyroidism in Europe. Acta Endocrinological Supplement, 90, 223–247.

    Google Scholar 

  • Delange, F., Bourdoux, P., Ketelbant-Balasse, P., Van Humskerken, A., Glinoer, D., & Ermans, A.M. (1983). Transient primary hypothyroidism in the newborn. In J.H. Dussault & P. Walker (Eds.), Basic and clinical endocrinology: Congenital hypothyroidism (pp. 275–301). New York: Marcel Dekker, Inc.

    Google Scholar 

  • Delange, F., Dodion, J., Wolter, R., Bourdoux, P., Dalhem, A., Glinoer, D., & Ermans, A. (1978). Transient hypothyroidism in the newborn infant. The Journal of Pediatrics, 92, 974–976.

    Article  PubMed  Google Scholar 

  • Dobbing, J., & Sands, J. (1973). Quantitative growth and development of human brain. Archives of Disease in Childhood, 48, 757–767.

    Article  PubMed  Google Scholar 

  • Dussault, J.H. (1987). Thyroid binding immunoglobulins and congenital hypothyroidism. Presented at the Lawson Wilkins Pediatric Endocrine Society Annual Meeting, Anaheim, California.

    Google Scholar 

  • Dussault, J.H. (November, 1988). The Quebec network for genetic medicine—CHUL. Congenital hypothyroidism. Abstract No. 022. International Symposium on Newborn Screening, Sao Paulo, Brazil.

    Google Scholar 

  • Dussault, J.H., Coulombe, P., LaBerge, C., Letarte, J., Guyda, H., & Khoury, J. (1975). Preliminary report on a mass screening program for neonatal hypothyroidism. Journal of Pediatrics, 86, 670–674.

    Article  PubMed  Google Scholar 

  • Dussault, J.H., Mitchell, M.L., LaFranchi, S., & Murphey, W.H. (1980). gional screening for congenital hypothyroidism: Results of screening one million North American infants with filter paper spot T4-TSH. In G.N. Burrow (Ed.), Neonatal thyroid screening (pp. 155–165). New York: Raven Press.

    Google Scholar 

  • Dussault, J.H., & Morissette, J. (1983). Higher sensitivity of primary thyrotropin in screening for congenital hypothyroidism: A myth? Journal of Clinical Endocrinology and Metabolism, 56, 849–852.

    Article  PubMed  Google Scholar 

  • Ermans, A.M., Boudoux, P., Lagasse, R., Delange, F., & Thilly, C. (1980). Congenital hypothyroidism in developing countries. In G.N. Burrow & J.H. Dussault (Eds.), Neonatal thyroid screening. New York: Raven Press.

    Google Scholar 

  • Farriaux, J.P., Dhondt, J.L., & Lebecq, M.R. (1988). Intellectual outcome in hypothyroid children screened at birth. Abstract No. 017. International Screening Symposium of Inborn Errors of Metabolism, Sa. Paulo, Brazil.

    Google Scholar 

  • Fellous, A., Lennon, A.M., Francon, J., & Nunez, J. (1979). Thyroid hormones and neurotubule assembly in vitro during brain development. European Journal of Biochemistry, 101, 365–376.

    Article  PubMed  Google Scholar 

  • Ferreira, P. (1986). Neonatal screening in Canada 1985: A survey. Unpublished manuscript.

    Google Scholar 

  • Ferreira, P. (1987). Canadian neonatal screening practices. In B.L. Therrell (Ed.), Advances in neonatal screening. Amsterdam: Elsevier.

    Google Scholar 

  • Fisher, D.A. (1975). Neonatal detection of hypothyroidism. The Journal of Pediatrics, 86, 822–824.

    Article  PubMed  Google Scholar 

  • Fisher, D.A. (1987). Maturation of thyroid hormone actions. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 21–24). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Fisher, D.A., & Klein, A.H. (1981). Thyroid development and disorders of thyroid function in the newborn. New England Journal of Medicine, 304, 702–712.

    Article  PubMed  Google Scholar 

  • Focarile, F., Rondanini, G.F., Bollati, A., Bartolucci, A., & Chiumello, G. (1984). Free thyroid hormones in evaluating persistently elevated thyrotropin levels in children with congenital hypothyroidism on replacement therapy. Journal of Clinical Endocrinology and Metabolism, 59, 1211–1214.

    Article  PubMed  Google Scholar 

  • Foley, T.P., & Murphey, W.H. (1980). Hypothyroidism at birth, during the first week of life and approximately one month of age: Comparison to primary T4 with secondary TSH screening. In G.N. Burrow (Ed.), Neonatal thyroid screening (pp. 75–86). New York: Raven Press.

    Google Scholar 

  • Frasier, S.D., Penny, R., & Snyder, R. (1982). Primary congenital hypothyroidism in Spanish-surnamed infants in Southern California. Journal of Pediatrics, 101, 315.

    PubMed  Google Scholar 

  • Frost, G.J., & Parkin, M.M. (1986). A comparison between the neurological and intellectual abnormalities in children and adults with congenital hypothyroidism. European Journal of Pediatrics, 145, 480–484.

    Article  PubMed  Google Scholar 

  • Fuggle, P., Murphy, G., Thorley, G., & Grant, D.B. (1989). Congenital hypothyroidism: Psychological outcome at three and five years. (Abstract) In F. De-lange, D.A. Fisher, D. Glinoer (Eds.) Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Fyro, K., & Bodegard, G., (1987). Four-year follow-up of psychological reactions to false positive screening tests for congenital hypothyroidism. Acta Paediatrica Scandinavica, 76, 107–114.

    Article  PubMed  Google Scholar 

  • Gesell, A., Amatruda, C.A., & Culotta, C.S. (1936). Effect of thyroid therapy on the mental and physical growth of cretinous infants. American Journal of Disease in Childhood, 52, 1117–1138.

    Google Scholar 

  • Glorieux, J., Desjardins, M., Dussault, J.H., Letarte, J., Morissette, J., & Thi-bault, L. (1987). Follow-up congenitally hypothyroid children: Delineation of a group at higher risk. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 81–84). Amsterdam-New York-Oxford: Excerpta Medica.

    Google Scholar 

  • Glorieux, J., Dussault, J.H., Letarte, J., Guyda, H., & Morissette, J. (1983). Preliminary results on the mental development of hypothyroid infants detected by the Quebec screening program. The Journal of Pediatrics, 102, 19–22.

    Article  PubMed  Google Scholar 

  • Glorieux, J., Desjardins, M., Letarte, J., Morissette, J., & Dussault, J.H. (1988). Useful parameter to predict the eventual mental outcome of hypothyroid children. Pediatric Research, 24, 6–8.

    Article  PubMed  Google Scholar 

  • Glorieux, J., Dussault, J.H., Morissette, J., Desfardins, M., Letarte, J., & Guyda, H. (1985). Follow-up at ages 5 and 7 years on mental development in children with hypothyroidism detected by Quebec screening program. The Journal of Pediatrics, 107, 913–915.

    Article  PubMed  Google Scholar 

  • Grant, D.B., & Hulse, J.A. (1980). Screening for congenital hypothyroidism. Archives of Disease in Childhood, 55, 913–914.

    Article  PubMed  Google Scholar 

  • Grant, G.A., Carson, D.J., McReid, M., & Hutchinson, J.M. (1986). Congenital hypothyroidism missed on screening. Archives of Disease in Childhood, 61, 189–197.

    Article  PubMed  Google Scholar 

  • Guyda, H.J., (1983). Treatment of congenital hypothyroidism. In J.H. Dussault & P. Walker (Eds.), Basic and clinical endocrinology: Congenital hypothyroidism (pp. 385–396). New York: Marcel Dekker, Inc.

    Google Scholar 

  • Hagberg, B., & Westphal, O. (1970). Ataxic syndrome in congenital hypothyroidism. Acta Paediatrica Scandinavica, 59, 323–327.

    Article  PubMed  Google Scholar 

  • Hahn, H.B., Spiekerman, A.M., Otto, W.R., & Hossalla, D.E. (1983). Thyroid function tests in neonates fed human milk. American Journal of Disease in Children, 137, 220–222.

    Google Scholar 

  • Hamburgh, M.N., Mendoza, L.A., Burkart, J.F., & Weil, F. (1971). Thyroid-dependent processes in the developing nervous system. In D.A. Hamburgh & E.J.W. Barrington (Eds.), Hormones in development. New York: Appleton-Century-Crofts.

    Google Scholar 

  • Hanefield, F., Richter, I., Weber, B., & Zabransky, S. (1974). Neurological studies on children with hypothyroidism on long-term treatment. Acta Pediatrica Scandinavica, 63, 332–333.

    Google Scholar 

  • Hebert, R., Laureau, E., Vanasse, M., Richard, J., Morrissette, J., Glorieux, J., Desjardins, M., Letarte, J., & Dussault, J. (1986). Auditory brainstem response audiometry in congenitally hypothyroid children under early replacement therapy. Pediatric Research, 20, 570–573.

    Article  PubMed  Google Scholar 

  • Heyerdahl, S. (1987). Development of children with congenital hypothyroidism diagnosed by neonatal screening in Norway. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 81–84). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Holmes, G. (1979). The cerebellum of man. Brain, 62, 1–30.

    Article  Google Scholar 

  • Holt, A.B., Kerr, G.R., & Cheek, D.B. (1975). Prenatal hypothyroidism and brain composition. In D.B. Cheek (Ed.), Fetal and post-natal cellular growth. Hormones and Nutrition. New York: John Wiley & Sons.

    Google Scholar 

  • Horn, G. (1955). Thyroid deficiency and inanition. The effects of replacement therapy on the development of the cerebral cortex of young albino rats. Anatomical Research, 121, 63.

    Article  Google Scholar 

  • Hulse, A.(1983). Congenital hypothyroidism and neurological development. Journal of Childhood Psychology and Psychiatry, 24, 629–635.

    Google Scholar 

  • Hulse, J.A. (1984). Outcome for congenital hypothyroidism. Archives of Disease in Childhood, 59, 23–30.

    Article  PubMed  Google Scholar 

  • Hulse, J.A., Grant, D.B., Clayton, B.E., Lilly, P., Jackson, D., Spracklan, A., Edwards, R.W.H., & Nurse, D. (1983). Population screening for congenital hypothyroidism. British Medical Journal, 280, 675–678.

    Article  Google Scholar 

  • Hulse, J.A., Grant, D.B., Jackson, D., & Clayton, B. (1982). Growth, development, and reassessment of hypothyroid infants diagnosed by screening. British Medical Journal, 284, 1435–1436.

    Article  PubMed  Google Scholar 

  • Ibanez, L., Albisu, M., Potau, N., Vicens-Calvet, E., & the Catalan Collaborative Group (1989). Follow-up of congenital hypothyroidism (CH) detected by neonatal screening in Catalonia. (Abstract) In F. Delange, D.A. Fisher, D. Glinoer (Eds.) Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Illig, R. (1983). Follow-up of thyroid function tests, skeletal maturation and scintigraphic findings with congenital hypothyroidism discovered by neonatal screening. In H. Naruse M., Irie (Eds.), Neonatal screening. Amsterdam: Excerpta Medica.

    Google Scholar 

  • Illig, R., & Largo, R.H. (1987). Mental development in 60 children with congenital hypothyroidism prospective follow-up study at one, four and seven years of age. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 85–89). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Illig, R., Largo, R.H., Qin, Q., Torresani, T., Rochiccioli, P., & Larsson, A. (1987). Mental development in congenital hypothyroidism after neonatal screening. Archives of Disease in Childhood, 62, 1050–1055.

    Article  PubMed  Google Scholar 

  • Illig, R., Largo, R.H., & Rochiccioli, P. (1985). European collaborative study on mental development in children with congenital hypothyroidism (CH) diagnosed by neonatal screening. Poster No. 73. Second joint meeting: Lawson Wilkins Pediatric Endocrine Society and European Society for Paediatric Endocrinology, Baltimore.

    Google Scholar 

  • Illig, R., Largo, R.H., Weber, M., Augsburger, T.H., Lipp, A., Wissler, D., Perrenoud, A.E., Torresani, T. (1986). Sixty children with congenital hypothyroidism detected by neonatal thyroid: Mental development at 1,4, and 7 years: a longitudinal study. Acta Endocrinologica, 279, 346–353.

    Google Scholar 

  • Interagency Committee on Learning Disabilities (1987). Learning disabilities: A report to the U.S. congress.

    Google Scholar 

  • Irie, M., Nakajima, H., Inomata, H., Naruse, H., Suwa, S., &Takasugi, N. (1987). Screening of neonatal hypothyroidism in Japan. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 41–47). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Jennings, P.E., O’Malley, B.P., Griffin, K.E., Northover, B., & Rosenthal, F.D. (1984). Relevance of increased serum thyroxine concentrations associated with normal serum triiodothyronine values in hypothyroid patients receiving thyroxine: A case for “tissue thyrotoxicosis.” British Medical Journal, 289, 1645–1647.

    Article  PubMed  Google Scholar 

  • Kirkland, R.T., Kirkland, J.L., Robertson, M.C., Librik, L., & Clayton, G.W. (1972). Strabismus and congenital hypothyroidism. The Journal of Pediatrics, 80, 648–650.

    Article  PubMed  Google Scholar 

  • Klein, A., Meltzer, S., & Kenny, F.M. (1972). Improved prognosis in congenital hypothyroidism treated before age three months. Journal of Pediatrics, 81, 912–915.

    Article  PubMed  Google Scholar 

  • Klein, R. (1986). Screening for congenital hypothyroidism. The Lancet, August, 403.

    Google Scholar 

  • Klein, R.Z. (1979). Neonatal screening for hypothyroidism. Advances in Pediatrics, 26, 417–440.

    PubMed  Google Scholar 

  • Klett, M., Schonberg, D., Bohnert, R. & Wille, L. (1983). Influence of various clinical conditions on thyroid function in the newborn. In H. Naruse & M. Irie (Eds.) Neonatal Screening Amsterdam: Excerpta Medica.

    Google Scholar 

  • Koldovsky, O., & Thornburg, W. (1987). Hormones in milk. Journal of Pediatric Gastro Nutrition, 6, 172–196.

    Article  Google Scholar 

  • Komianou, F., Makaronis, G., Lambadaridis, J., Sarafidou, R., Vrachni, F., Mengreli, C., & Pantelakis, S. (1988). Psychomotor development in congenital hypothyroidism. European Journal of Pediatrics, 147, 275–278.

    Article  PubMed  Google Scholar 

  • Konstantarcas, M., & Homatidis, S. (November, 1988). Evidence of pre, peri- and neonatal complications in the births of autistic, mentally retarded and normal children. Presented at Challenge and Change in Childhood Psychopathology Conference, Toronto.

    Google Scholar 

  • Laberge, C. (1983). Cost benefit evaluation of neonatal thyroid screening programs. In G.N. Burrow & J.H. Dussault, Neonatal thyroid screening. New York: Raven.

    Google Scholar 

  • Ladenson, P.W., Stokes, J.W., & Ridgway, E.C. (1984). Reversible alteration of the visual evoked potential in hypothyroidism. The American Journal of Medicine, 77, 1010–1014.

    Article  PubMed  Google Scholar 

  • LaFranchi, S.H., Hannna, C.E., Krainz, P.L., Skeels, M.R., Miyahira, R. S., & Sesser, D.E. (1985). Screening for congenital hypothyroidism with specimen collection at two time periods: Results of the northwest regional screening program. Pediatrics, 76, 734–740.

    PubMed  Google Scholar 

  • LaFranchi, S.H., Murphey, W.H., Foley, J.P., Larsen, P.R., & Buist, N.R. (1979). Neonatal hypothyroidism detected by the northwest regional screening program. Pediatrics, 63, 180–191.

    PubMed  Google Scholar 

  • Larsen, P.R., & Broskin, K. (1975). Thyroxine immunoassay using capillary blood samples collected on filter paper. In D. A. Fisher & G.N. Burrow (Eds.), Perinatal thyroid physiology and disease. New York: Raven Press.

    Google Scholar 

  • Lauder, J.M., & Krebs, H. (1986). Do neurotransmitter, neurohumors, and hormones specify critical periods? In W.T. Greenough & J.M. Juraska (Eds.), Developmental neuropsychobiology. New York: Academic Press.

    Google Scholar 

  • Layde, P.M., Von Allmen, S.D., & Oakley, G.P. (1979). Congenital hypothyroidism control programs. A cost-benefit analysis. Journal of the American Association, 241, 2290–2292.

    Article  Google Scholar 

  • Legrand, J. (1986). Thyroid hormone effects on growth and development. In G. Hennemann (Ed.), Thyroid hormone metabolism. New York: Marcel Dekker.

    Google Scholar 

  • Leiner, H.C., Leiner, A.L., & Dow, R.S. (1986). Does the cerebellum contribute to mental skills? Behavioural Neuroscience, 100, 443–454.

    Article  Google Scholar 

  • Letarte, J., Guyda, J., Dussault, J.H., & Glorieux, J. (1980). Lack of protective effect of breast-feeding in congenital hypothyroidism: Report of 12 cases. Pediatrics, 65, 703–705.

    PubMed  Google Scholar 

  • Letarte, J. & La Franchi, S. (1983). Clinical features of congenital hypothyroidism. In J.H. Dussault & P. Walker (Eds.) Basic and clinical endocrinology: Congenital hypothyroidism (pp. 351–383). New York: Marcel Dekker.

    Google Scholar 

  • Levine, G.D., & Therrell, B.L. (1986). Second testing for hypothyroidism. Pediatrics, 78, 375–376.

    PubMed  Google Scholar 

  • Levine, M.D., Oberklaid, F., &Meltzer, L. (1981). Developmental output failure: A study of low productivity in school-aged children. Pediatrics, 67, 18–25.

    PubMed  Google Scholar 

  • Lewis, A. (1937). A study of cretinism in London. Lancet, 2, 1501–1525.

    Google Scholar 

  • MacFaul, R., Dorner, S., Brett, E.M., & Grant, D.B. (1978). Neurological abnormalities in patients treated for hypothroidism from early life. Archives of Disease in Childhood, 53, 611–619.

    Article  PubMed  Google Scholar 

  • Maenpaa, J. (1972). Congenital hypothyroidism: Aetiological and clinical aspects. Archives of Disease in Childhood, 47, 914–923.

    Article  PubMed  Google Scholar 

  • Maki, I., Nose, O., Harada, T., Kai, H., Tajiri, H., Ogawa, M., Abe, M., Miyai, K., Mizuta, M., Takesada, M., Yabuuchi, H. (1983) Follow up study of treated hypothyroid infants on psychological and neurological development. In H. Naruse & M. Irie (Eds.), Neonatal Screening. Amsterdam: Excerpta Medica.

    Google Scholar 

  • Malone, M.J., Rosman, N.P., Szoke, M., & Davis, D. (1976). Myelination of brain in experimental hypothyroidism. Journal of the Neurological Sciences, 26, 1–11.

    Article  Google Scholar 

  • Man, E.B., & Serunian, S.A. (1976). Thyroid function in human pregnancy. American Journal of Obstetrics and Gynaecology, 125, 949–957.

    Google Scholar 

  • Mitchell, M.L. (1986). Screening for congenital hypothyroidism: A decade later. Infant Screening Newsletter, Vol. 11.

    Google Scholar 

  • Mitchell, M.L., Larsen, R., Levy, H.L., Bennett, A.J., & Madoff, M.A. (1978). Screening for congenital hypothyroidism. Journal of the American Medical Association, 239, 2348–2351.

    Article  PubMed  Google Scholar 

  • Mizuta, H., Amino, N., Ichihara, K., Harade, T., Nose, O., Tanizawa, O., & Miyai, K. (1983). Thyroid hormones in human milk and their influence on thyroid function of breast-fed babies. Pediatric Research, 14, 468–471.

    Google Scholar 

  • Money, J. (1956). Psychologic studies in hypothyroidism. Archives of Neurology in Psychiatry, 76, 296–309.

    Google Scholar 

  • Morreale de Escobar, G., Escobar del Rey, F., Ruiz-Marcos, A. (1983). Thyroid hormone and the developing brain. In J.H. Dussault & P. Walker (Eds.), Congenital hypothyroidism. New York: Dekker.

    Google Scholar 

  • Morreale de Escobar, G., Obregon M.J., Escobar del Rey F (1989). Transfer of thyroid hormone from mother to fetus In F. Delange, D.A. Fisher, D. Glineoer (Eds), Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Morreale de Escobar, G., Pastor, R., Obregon, M.J., & Escobar del Rey, F. (1985). Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology, 117, 1890–1900.

    Article  PubMed  Google Scholar 

  • Moschini, L., Costa, P., Marinelli, E., Maggioni, G., Sorcini Carta, M., Fazzini, D., Diodato, A. , Sabini, G., Grandolfo, M.E., Carta, S., Porro, G., Paolella, A., Gordiale, S., & Brinciotti, M. (1986). Longitudinal assessment of children with congenital hypothyroidism detected by neonatal screeing. Helv Paediatrica Acta, 41, 415–24.

    Google Scholar 

  • Moschini, L., Sorcini, C., Costa, P., Antonozzi, I., Paolella, A., Porro, G., & Carta, S. (1989). Mental development in 75 children with congenital hypothyroidism detected by neonatal screening. In F. Delange, D.A. Fisher, D. Glinoer (Eds.) Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Muir, A., Daneman, D., Daneman, A., & Ehrlich, R. (1988). Thyroid scanning ultrasound, and serum thyroglobulin in determining the origin of congenital hypothyroidism. American Journal of Diseases in Children, 142, 214–216.

    Google Scholar 

  • Murphy, G., Hulse, J.A., Jackson, D., Tyner, P., Glossop, J., Smith, I., & Grant, D. (1986). Early treated hypothyroidism: Development at 3 years. Archives of Disease in Childhood, 61, 761–765.

    Article  PubMed  Google Scholar 

  • Myant, N.B. (1971). The role of thyroid hormone in the fetal and postnatal development of mammals. In D.A. Hamburgh & E.J.W. Barrington (Eds.), Hormones in development. New York: Appleton-Century-Crofts.

    Google Scholar 

  • New England Congenital Hypothyroidism Collaborative (November, 1981). Effects of neonatal screening for hypothyroidism: Prevention of mental retardation by treatment before clinical manifestations. Lancet, 2, 1095–1098.

    Google Scholar 

  • New England Congenital Hypothyroidism Collaborative (1982). Pitfalls in screening for neonatal hypothyroidism. Pediatrics, 70, 16–20.

    Google Scholar 

  • New England Congenital Hypothyroidism Collaborative (1984). Characteristics of infantile hypothyroidism discovered on neonatal screening. The Journal of Pediatrics, 104, 539–544.

    Article  Google Scholar 

  • New England Congenital Hypothyroidism Collaborative (1985). Neonatal hypothyroidism screening: Status of patients at 6 years of age. The Journal of Pediatrics, 107, 915–918.

    Article  Google Scholar 

  • Nicholson, J.L., & Altman, J. (1972). Synoptogenesis in the rat cerebellum. Effects of early hypo and hyperthyroidism. Science, 176, 530–531.

    Article  PubMed  Google Scholar 

  • Nunez, J. (1984). Thyroid hormones and microtubules during brain development. International Endocrine Society Meeting, Quebec City.

    Google Scholar 

  • Osier, W. (1897). Sporadic cretinism in America. Transactions of the Congress of American Physicians and Surgeons, 4, 169.

    Google Scholar 

  • Pekonen, B., & Pekonen, F. (1984). Ontogenesis of the nuclear 3,4,3′-triiodothy-ronine receptor in the human fetal brain. Endocrinology, 114, 677–679.

    Article  PubMed  Google Scholar 

  • Pelton, W., & Bass, N.H. (1973). Adverse affects of excess thyroid hormone on the maturation of rat cerebrum. Archives of Neurology, 29, 145–150.

    Google Scholar 

  • Perez-Castillo, A., Bernal, J., Ferreiro, B., & Pans, T. (1985). The early ontogenesis of thyroid hormone receptor in rat fetus. Endocrinology, 111, 2457–2461.

    Article  Google Scholar 

  • Peter, F., Wang, S.T., & Strunc, G. (1987). Screening for congenital hypothyroidism with a one-day TSH assay. Immunoradimetric (IRMA) and immunofluo-rometric (IFMA) tests compared. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 61–62). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Plioplys, A. V., Gravel, C., & Hawkes, R. (1986). Selective suppression of neurofilament antigen expression in the hypothyroid rat cerebral cortex. Journal of the Neurological Sciences, 75, 53–68.

    Article  PubMed  Google Scholar 

  • Potter, B.J., Mano, M.T., Belling, G.B., Mclntosch, G.H., Hua, C., Cragg, B.G., Marshall, J., Wellby, M.L., & Hetzel, B.S. (1982). Retarded fetal brain development resulting from severe dietary iodine deficiency in sheep. Neuropathology and Applied Neurobiology, 8, 303–313.

    Article  PubMed  Google Scholar 

  • Price, D.A., Ehrlich, R.M., & Walfish, P.G. (1981). Congenital hypothyroidism: Clinical and laboratory characteristics in infants detected by neonatal screening. Archives of Disease in Childhood, 56, 845–851.

    Article  PubMed  Google Scholar 

  • Raiti, S., & Newns, G.H. (1971). Cretinism: Early diagnosis and its relation to mental prognosis. Archives of Disease in Childhood, 46, 692–694.

    Article  PubMed  Google Scholar 

  • Redmond, G.P. (1982). Therapy of congenital hypothyroidism in the era of mass screening. Seminars in Perinatology, 6, 181–189.

    PubMed  Google Scholar 

  • Rezvani, I., & DiGeorge, A.M. (1977). Reassessment of the daily dose of oral thyroxine for replacement therapy in hypothyroid children. Pediatrics, 90, 291–297.

    Article  Google Scholar 

  • Richards, G.E., Karyl, A., Norcross, A., & Cavallo, A. (1987). Evoked potential in newborns with congenital hypothyroidism. Abstract No. 476, Pediatric Research Program, 21, 253A.

    Google Scholar 

  • Rickards, A., Coakley, J., Francis, I., Armstrong, S., & Connelly, J., (1988). Results of follow-up at 5 years in a group of hypothyroid Australian children detected by newborn screening. (Abstract) In F. Delange, D.A. Fisher, D. Glinoer (Eds.) Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Rickards, A., Connelly, J., Coakley, J., & Armstrong, S. (1987). Psychological follow-up in Australian hypothyroid children detected by newborn screening. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 77–80). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Rives, S., & Toublanc, J.E. (1987). Cognitive and affective outcomes of congenital hypothyroid follow-up. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 109–112). Amsterdam-New York-Oxford: Exerpta Medica.

    Google Scholar 

  • Rochiccioli, P., Roge, B., Alexandre, F., & Dutau, G. (1983). Study of perinatal and environmental factors of neuropsychological development of hypothyroid infants detected by neonatal screening. In H. Naruse & M. Irie (Eds.), Neonatal screening. Amsterdam: Excerpta Medica.

    Google Scholar 

  • Roge, B., Rochiccioli, P., Alexandre, F., & Moron, P. (1987). An eight-year study of the mental and psychomotor development of hypothyroid children detected by neonatal screening. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 91–94). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Rondanini, G.F., Bollati, A., Della Porta, V., Cerabolini, R., Lenti, C., Rovej, L., Manzoni, A., & Chumello, G. (1989) Long term neurological prognosis in early treated congenital hypothyroid children. (Abstract) In F. Delange, D. A. Fisher, D. Glinoer (Eds.) Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Rosman, N.P. (1976). Neurological and muscular aspects of thyroid dysfunction in childhood. Pediatric Clinics of North America, 23, 575–594.

    PubMed  Google Scholar 

  • Rovet, J.F. (1989). Does breast feeding protect the hypothyroid infant diagnosed by newborn screening? Manuscript submitted for publication.

    Google Scholar 

  • Rovet, J., & Ehrlich, R. (1988). Thyroid screening follow-up study. Final report to the Ontario Ministry of Health.

    Google Scholar 

  • Rovet, J., Ehrlich, R., & Sorbara, D. (1987a). Intellectual outcome in children with fetal hypothyroidism. Journal of Pediatrics, 110, 700–704.

    Article  PubMed  Google Scholar 

  • Rovet, J., Ehrlich, R., & Sorbara, D. (1987b). Longitudinal prospective investigations of hypothyroid children detected by neonatal thyroid screening in Ontario. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (pp. 99–103). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Rovet, J.F., Ehrlich, R.M., & Sorbara, D. (1989). Effect of thyroid hormone level on temperament in infants with congenital hypothyroidism detected by screening of neonates. Journal of Pediatrics, 114, 63–68.

    Article  PubMed  Google Scholar 

  • Rovet, J.F., Sorbara, D.L., & Ehrlich, R.M. (1986). The intellectual and behavioural characteristics of children with congenital hypothyroidism identified by neonatal screening in Ontario. The Toronto prospective study. In Genetic disease: Screening and management (pp. 281–315). New York: Liss.

    Google Scholar 

  • Sack, J., Frucht, H., Amadeo, O., Brish, M., & Lunenfeld, B. (1981). Breast milk thyroxine and not cow’s milk may mitigate and delay the clinical picture of neonatal hypothyroidism. Acta Paediatrica Scandinavica, 277, 54–56.

    Google Scholar 

  • Sato, T., & Suzuki, Y. (1979). Presence of tri-iodothyronine, no detectable thyroxine and reverse tri-iodothyronine in human milk. Endocrinology Japan, 26, 507–513.

    Article  Google Scholar 

  • Schapiro, S. (1966). Metabolic and maturational effects of thyroxine in the infant rat. Endocrinology, 78, 527–532.

    Article  PubMed  Google Scholar 

  • Siegel, L.S., & Heaven, R. (1986). Defining and categorizing learning disabilities. In S. Ceci (Ed.), Handbook of cognitive, social and neuropsycholgoical aspects of learning disabilities, 1, 95–121. Hillsdale, NJ: Ehrlbaum.

    Google Scholar 

  • Smith, D.W., Blizzard, R.M., & Wilkins, L. (1957). The mental prognosis in hypothyroidism of infancy and childhood, Pediatrics, 19, 1011–1022.

    PubMed  Google Scholar 

  • Tenore, A., Militerni, R., D’Argenzio, G., DiMaio, S., Lubrano, P., Sandomenico, M.L., Mariano, A., & Varrone, S. (1987). Screening for congenital hypothyroidism in the region of Campania (Italy): Preliminary data on neuro-psychomotor follow-up. In B.L. Therrell Jr. (Ed.), Advances in neonatal screening (p. 107). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Tenore, A., Parks, J.S., & Bongiovanni, A.M. (1977). Relationship of breast feeding to congenital hypothyroidism. In G. Chiumello & Z. Laron (Eds.), Recent progress in pediatric endocrinology. New York: Academic Press.

    Google Scholar 

  • Therrell, B.L. (1987). National screening status report. Infant Screening, 10, 5–6.

    Google Scholar 

  • Therrell, B.L., Meyer, D., Brown, L.O. et al. (1982). Incidence of primary congenital hypothyroidism in Texas by race and sex. In R.H. Dobbins (Ed.), Proceedings of the 1982 National Newborn Screening Symposium (pp. 57–60). Chicago, Illinois Department of Health.

    Google Scholar 

  • Thieffry, A.F., Dhondt, J.L., Farriaux, J.P., & Parquet, P. (1983) Psychological cost of neonatal screening to families. In H. Naruse & M. Irie (Eds.), Neonatal screening. Amsterdam: Excerpta Medica.

    Google Scholar 

  • Thompson, G.N., McCrossin, R.B., Penfold, J.L., Woodroffe, P., Rose, W.A., & Robertson, E.F. (1986). Management and outcome of children with congenital hypothyroidism detected on neonatal screening in South Australia. The Medical Journal of Australia, 145, 18–22.

    PubMed  Google Scholar 

  • Thyroid Foundation of America (1986). Newsletter. Massachusetts General Hospital, Boston.

    Google Scholar 

  • Toublanc, J.E., Rives, S., & Job, J.C. (1989). Factors related to the intellectual development of children treated for congential hypothyroids m. (Abstract) In F. Delange, D.A. Fisher, D. Glinoer (Eds). Research in Congenital Hypothyroidism New York: Plenum.

    Google Scholar 

  • United States Department of Education. Information provided by Office of Special Education, U.W. Department of Education.

    Google Scholar 

  • Vanderschueren-Lodeweyckx, M., Debruyne, F., Dooms, L., Eggermont, E., & Eeckels, R. (1983). Sensorineural hearing loss in sporadic congenital hypothyroidism. Archives of Disease in Children, 58, 419–422.

    Article  Google Scholar 

  • Vanderschueren-Lodeweyckx, M., Malvaux, P., Craen, M., Ernould, C., & Wolter, R. (1980). Neuropsychological study of treated children with thyroid dysgenesis. In G.N. Burrow & J.H. Dussault (Eds.), Neonatal thyroid screening. New York: Raven Press.

    Google Scholar 

  • VanVliet G., Barboni T., Klees M., Cantraine F., Wolter F. Treatment strategy and long term follow up of congenital hypothyroidism. In F. Delange, D.A. Fisher, D. Glinoer (Eds.) Research in Congenital Hypothyroidism. New York: Plenum.

    Google Scholar 

  • Virtanen, M., Maenpaa, J., Santavuori, P., Hirovonen, E., & Perheentupa, J. (1983). Congenital hypthyroidism: Age at start of treatment versus outcome. Acta Paediatrica Scandinavica, 72, 197–201.

    Article  PubMed  Google Scholar 

  • Walfish, P.G. (1981). Thyroid physiology and pathology. In R. Collu et al. (Eds.), Pediatric endocrinology. New York: Raven Press.

    Google Scholar 

  • Walfish, P.G. (Feb. 1984). The best way to screen for neonatal hypothyroidism. Diagnostic Medicine, 7:57–75.

    Google Scholar 

  • Walfish, P.G., Gera, E., & Ehrlich, R.M. (1983). Primary TSH screening for neonatal hypothyroidism. Results of simultaneous cord and neonatal heel blood testing within the same infant population. In H. Naruse & M. Irie (Eds.), Neonatal screening. Amsterdam: Excerpta Medica.

    Google Scholar 

  • Walfish, P.G., Ginsberg, J., Rosenberg, R.A., & Howard, N.J. (1979). Results of a regional cord blood screening program for detecting neonatal hypothyroidism. Archives of Disease in Childhood, 54, 1–7.

    Article  Google Scholar 

  • Weichsel, M.E. (1978). Thyroid hormone replacemnt therapy in perinatal period: Neurological consideration. Pediatrics, 92, 1035–1038.

    Article  Google Scholar 

  • Wolter, R., Noel, P., deCock, P., Craen, M., Enould, C.H., Malvaux, P., Verstraetan, F., Simons, J., Mertans, S., & Van Broeck, N. (1979). Neuro-psycholgoical study in treated thyroid dysgenesis. Acta Paediatrica Scandinavica Supplement, 277, 41–46.

    Article  PubMed  Google Scholar 

  • Yoshida, K., Sakurada, T., Takahashi, T., Furuhashi, N., Kiase, K., & Yoshi-naga, K. (1986). Measurement of TSH in human aminiotic fluid: Diagnosis of fetal thyroid abnormality in utero. Clinics of Endocrinology, 25, 313–318.

    Article  Google Scholar 

  • Zetterstrom, R. (1988). Psychological consequences of false-positive results. Abstract No. 14. International Screening Symposium of Inborn Errors of Metabolism, San Paulo, Brazil.

    Google Scholar 

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  1. Joanne F. Rovet
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  1. Departments of Psychology and Pediatrics, Tulane University, New Orleans, Louisiana, 70118, USA

    Clarissa S. Holmes

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Rovet, J.F. (1990). Congenital Hypothyroidism: Intellectual and Neuropsychological Functioning. In: Holmes, C.S. (eds) Psychoneuroendocrinology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3306-0_17

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