Prenatal Diagnosis of Renal and Urinary Tract Abnormalities

  • Philippe Jeanty
  • Manfred Hansmann

Abstract

Prenatal diagnosis of renal and urinary tract abnormalities may be achieved by fetal ultrasonography. With improvement in techniques used to obtain and study fetal tissue, the prenatal diagnosis of conditions associated with renal disease also became possible. Sonographically diagnosed malformations occur in about 0.5% of fetuses, 50% of which are due to renal tract abnormalities (1). Of pregnancies with positive family history of renal tract anomalies, 8% were also found to have urinary tract abnormalities by ultrasound (2). In this chapter, we will review the indications and techniques of prenatal diagnosis of renal tract anomalies, present some of the commonly seen ones and touch on the management and follow-up of affected fetuses.

Keywords

Catheter Hydrocephalus Furosemide Nephritis Verse 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Helin I, Persson P-H (1986) Prenatal diagnosis of urinary tract abnormalities by ultrasound. Pediatrics 78: 879–883PubMedGoogle Scholar
  2. 2.
    Reuss A, Wladimiroff JW, Niiermeijer MF (1987) Antenatal diagnosis of renal tract anomalies by ultrasound. Pediatr Nephrol 1: 546–552PubMedCrossRefGoogle Scholar
  3. 3.
    Hansmann M, Hackelöer B-J, Staudach A (1986) Ultrasound Diagnosis in Obstetrics and Gynecology. Springer-Verlag, Berlin, pp 223–237Google Scholar
  4. 4.
    Romero R, Pilu GL, Jeanty P, et al (1987) Prenatal Diagnosis of Congenital Anomalies. Appleton and Lange, Norwalk, pp 301–311Google Scholar
  5. 5.
    Barakat AY, Awazu M, Fleischer AC (1989) Antenatal diagnosis of renal abnormalities: a review of the state of the art. South Med J 82: 229–234PubMedCrossRefGoogle Scholar
  6. 6.
    Jeanty P, Dramaix-Wilmet M, Elkhazen N, et al (1982) Measurement of fetal kidney growth on ultrasound. Radiology 144: 159–162PubMedGoogle Scholar
  7. 7.
    Raghavendra BN, Young BK, Greco MA, et al (1987) Use of furosemide in pregnancies complicated by oligohydramnios. Radiology 165: 455–458PubMedGoogle Scholar
  8. 8.
    Harms E (1987) Prenatal diagnosis of inborn errors of metabolism with renal manifestations. Pediatr Nephrol 1: 540–545PubMedCrossRefGoogle Scholar
  9. 9.
    Reeders ST, Breuning MH, Davies KE, et al (1985) A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16. Nature 317: 542–544PubMedCrossRefGoogle Scholar
  10. 10.
    Reeders ST, Gal A, Propping P, et al (1986) Prenatal diagnosis of autosomal dominant polycystic kidney disease with DNA probe. Lancet 2: 6–8PubMedCrossRefGoogle Scholar
  11. 11.
    Ostrer H, Hejtmancik JF (1988) Prenatal diagnosis and carrier detection of genetic diseases by analysis of deoxyribonucleic acid. J Pediatr 112: 679–687PubMedCrossRefGoogle Scholar
  12. 12.
    Menlove L, Kirschner N, Nguyen K, et al (1985) Linkage between Alport syndrome-like hereditary nephritis and X-linked PFLPs. Cytogenet Cell Genet 40: 697–698Google Scholar
  13. 13.
    Flinter FA, Bobrow M, Chantier C (1987) Alport’s syndrome or hereditary abnormalities of other systems nephritis? Pediatr Nephrol 1: 438–440PubMedCrossRefGoogle Scholar
  14. 14.
    Nicolaides KH, Rodeck CH, Gosden CM (1986) Rapid karyotyping in non-lethal fetal malformations. Lancet 1: 283–287PubMedCrossRefGoogle Scholar
  15. 15.
    Harrison MR, Golbus MS, Filly RA, et al (1982) Fetal surgery for congenital hydronephrosis. N Engl J Med 306: 591–593PubMedCrossRefGoogle Scholar
  16. 16.
    Golbus MS, Harrison MR, Filly RA, et al (1982) In utero treatment of urinary tract obstruction. Am J Obstet Gynecol 142: 383–388PubMedGoogle Scholar
  17. 17.
    Report of the International Fetal Surgery Registry (1986) Catheter shunts for fetal hydronephrosis and hydrocephalus. N Engl J Med 315: 336–340CrossRefGoogle Scholar
  18. 18.
    Arant BS, Jr (1987) Prevention of hereditary nephropathies by antenatal interventions. Ethical considerations. Pediatr Nephrol 1: 553–560PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • Philippe Jeanty
  • Manfred Hansmann

There are no affiliations available

Personalised recommendations