Abstract
Renal tubular diseases are a group of relatively uncommon disorders that can affect children of all ages and that have in common the development of disease because of renal hyperexcretion of ions or organic molecules that are normally reabsorbed by the kidney. Several characteristics of these disorders are largely universal and worth comment (1):
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1.
These disorders are usually inherited; more than one child in a family may be affected.
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2.
The children frequently present with growth failure.
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3.
They can be diagnosed by a simultaneous assessment of the serum and urine concentration of the substance that is being lost.
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4.
The principle of treatment usually involves the replacement of the substance lost in the urine. However, some disorders relate to the hyperexcretion of a toxic substance, such as cystine, which leads to damage, because it is insoluble or a metabolic poison.
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5.
Some of these disorders are benign and require no therapy. Thus, it is important to make the proper diagnosis so that unnecessary therapy can be avoided.
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Chesney, R.W. (1990). Clinical Study of Renal Tubular Disease. In: Barakat, A.Y. (eds) Renal Disease in Children. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3260-5_11
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DOI: https://doi.org/10.1007/978-1-4612-3260-5_11
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