Abstract
In principle, electrical stimulation of the cochlea is a simple process. Intracochlear electrodes, when stimulated, create electrical field patterns within the cochlea. In the vicinity of the neural elements, these fields appear as extracellular voltage gradients or profiles that are continuous along the entire length of the neurons. These extracellular voltage fields produce current flow into and out of the neural elements depending on the local impedances of the neural membranes. If the neural elements are sufficiently depolarized, action potentials are generated that propagate along each cell’s axon to the cochlear nucleus. Globally these events occur simultaneously, but in varying degree, across a population of nerve cells, producing a group or ensemble of neural responses to the stimulation.
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References
Békésy, G. von (1951). The course pattern of the electrical resistance in the cochlea of the guinea pig (electro-anatomy of the cochlea). J. Acoust. Soc. Am. 23:18-28. Reprinted in Experiments in Hearing, by G. von Bekesy ( McGraw- Hill, New York ), 1960, pp. 684–703.
Black, R.C., and Clark, G.M. (1980). Differential electrical excitation of the auditory nerve. J. Acoust. Soc. Am. 67: 868–874.
Cannon, M.W., Jr. (1976). Electrical impedances, current pathways and voltage sources in the guinea pig cochlea. Institute for Sensory Research Report ISR-S-14, Syracuse University, Syracuse, N.Y.
Coburn, B. (1980). Electrical stimulation of the spinal cord: Two-dimensional finite element analysis with particular reference to epidural electrodes. Med. Biol. Eng. Comp. 18: 573–584.
Colombo, J., and Parkins, C.W. (1987). A model of electrical excitation of the mammalian auditory-nerve neuron. Hearing Res. 31: 287–312.
Finley, C.C., and Wilson, B.S. (1985). An integrated field-neuron model of electrical stimulation by intracochlear scala tympani electrodes. Abstracts of the 8th Midwinter Research Meeting of the Association for Research in Otolaryngology, pp. 105–106.
Finley, C.C., Wilson, B.S., and White, M.W. (1987). A finite-element model of bipolar field patterns in the electrically stimulated cochlea—A two-dimensional approximation. Proceedings of the Ninth Annual Conference of the IEEE Engineering in Medicine and Biology Society, Boston, pp. 1901–1903.
Frankenhaeuser, B., and Huxley, A.F. (1964). The action potential in the myelinated nerve fiber of Xenopus laevis as computed on the basis of voltage clamp data. J. Physiol. (London) 171: 302–315.
Grizon, G. (1987). Investigation of current flow in the inner ear during electrical stimulation of intracochlear electrodes. MS thesis in EE CS, MIT, Cambridge, Mass.
Hinojosa, R., and Marion, M. (1983). Histopathology of profound sensorineural deafness. Ann. N.Y. Acad. Sci. 405: 459–484.
Honrubia, V., Strelioff, D., and Sitko, S. (1974). Electroanatomy of the cochlea: Its role in cochlear potential measurements. Proceedings of the International Congress in Electrocochleography, Bronx, N.Y.
Javel, E., Tong, Y.C., Shepherd, R.K., and Clark, G.M. (1987). Responses of cat auditory nerve fibers to biphasic electrical current pulses. Ann. Otol. Rhinol. Laryngol. 96, Suppl. 128: 26–30.
Johnstone, B.M., Johnstone, J.R., and Pugsley, I.D. (1966). Membrane resistance in endolymphatic walls of the first turn of the guinea-pig cochlea. J. Acoust. Soc. Am. 40: 1398–1404.
Laurence, M. (1980). Factors in the continuing development of auditory prostheses. In Controversies in Otolaryngology, edited by J.B. Snow ( Saunders, Philadelphia ), pp. 433–442.
Leake-Jones, P.A., and Rebscher, S.J. (1983). Cochlear pathology with chronically implanted scala tympani electrodes. Ann. N.Y. Acad. Sci. 405: 203–223.
Liberman, M.C., and Oliver, M.E. (1984). Morphometry of intracellularly labeled neurons of the auditory nerve: Correlations with functional properties. J. Comp. Neurol. 223: 163–176.
Loeb, G.E., Byers, C.L., Rebscher, S.J., Casey, D.E., Fong, M.M., Schindler, R.A., Gray, R.F., and Merzenich, M.M. (1983). Design and fabrication of an experimental cochlear prosthesis. Med. Biol. Eng. Compt. 21: 241–254.
McNeal, D.R. (1976). Analysis of a model for excitation of myelinated nerve. IEEE BME 23 (4): 329–337.
Merzenich, M.M., and White, M.W. (1977). Cochlear implant. The interface problem. Biomed. Eng. Instrum. Funct. Electr. Stimul. 3: 321–340.
Miller, C.E., and Henriquez, C.S. (1988). Three-dimensional finite element solution for biopotentials: Erythrocyte in an applied field. IEEE ’ BME 35 (9): 712–718.
Misrahy, G.A., Hildreth, K.M., Shinabarger, E.W., and Gannon, W.J. (1958). Electrical properties of the wall of the endolymphatic space of the cochlea (guinea pig). Am. J. Physiol. 194: 396–402.
Patrick, J.F., Crosby, P.A., Hirshorn, M.S., Kuzma, J.A., Money, D.K., Ridler, J., and Seligman, P.M. (1985). Australian multi-channel implantable hearing prosthesis. In Cochlear Implants, edited by R.A. Schindler and M.M. Merzenich ( Raven Press, New York ), pp. 93–100.
Pernkopf, E. (1960). Topographische Anatomie des Menschen IV. Band: Topographische and stratigraphische Anatomie des Kopfes. Zweite Halfte, Urban and Schwarzenberg, Berlin, p 599. (Note: 3rd English edition published in 1989 by Urban and Schwarzenberg, Baltimore-Munich).
Ranck, J.B. (1975). Which elements are excited in electrical stimulation of mammalian central nervous system: A review. Brain Res. 98: 417–440.
Rattay, F. (1986). Analysis of models for external stimulation of axons. IEEE BME 33 (10): 974–977.
Rattay, F. (1987). Ways to approximate current-distance relations for electrically stimulated fibers. J. Theor. Biol. 125: 339–349.
Reilly, J.P., Freeman, V.T., and Larkin, W.D. (1985). Sensory effects of transient electrical stimulation—Evaluation with a neuroelectric model. IEEE BME 32 (12): 1001–1011.
Reilly, J.P., and Bauer, R.H. (1987). Application of a neuroelectric model to electrocutaneous sensory sensitivity: Parameter variation study. IEEE BME 34 (9): 752–754.
Rubinstein, J.T., Soma, M., and Spelman, F.A. (1985). Mixed boundary value problem in the implanted cochlea: An analytical model of a cylindrical banded electrode array. IEEE 17 th Conf. EMBS, 1120–1123.
Shepherd, R.K., Clary, G.M., Pyman, B.C., and Webb, R.L. (1985). The banded intracochlear electrode array: An evaluation of insertion trauma. Ann. Otol. Rhinol. Laryngol. 94: 55–59.
Sitko, S. (1976). Electrical network properties of the guinea pig cochlea. Doctoral dissertation, University of California, San Diego, Calif.
Soma, M., Spelman, F.A., and Rubinstein, J.T. (1984). Fields produced by the cochlear prosthesis: The ear as a multilayered medium. IEEE Frontiers of Engineering Computing in Health Care, pp. 401–405.
Spelman, F.A., Clopton, B.M., and Pfingst, B.E. (1982). Tissue impedance and current flow in the implanted ear. Implications for the cochlear prosthesis. Ann. Otol. Rhinol. Laryngol. Suppl. 98, 91: 3–8.
Spelman, F.A., and Clopton, B.M. (1987). Measurement of the specific impedance of bony tissues in the guinea pig cochlea. Abstracts of the 10th Midwinter Research Meeting of the Association for Research in Otolaryngology, #41.
Strelioff, D. (1973). A computer simulation of the generation and distribution of cochlear potentials. J. Acoust. Soc. Am. 54: 620–629.
Stypulkowski, P.H., and van den Honert, C. (1984). Physiological properties of the electrically stimulated auditory nerve. I. Compound action potential recordings. Hearing Res. 14: 205–223.
Sweeney, J.D., Mortimer, J.J., and Durand, D. (1987). Modeling of mammalian myelinated nerve for functional neuromuscular stimulation. Proceedings of the Ninth Annual Conference of the IEEE Engineering in Medicine and Biology Society, Boston, p. 1577.
van den Honert, C., and Stypulkowski, P.H. (1987a). Single fiber mapping of spatial excitation patterns in the electrically stimulated auditory nerve. Hearing Res. 29: 195–206.
van den Honert, C., and Stypulkowski, P.H. (1987b). Temporal response patterns of single auditory nerve fibers elicited by periodic electrical stimuli. Hearing Res. 29: 207–222.
Verveen, A.A., and Derksen, H.E. (1968). Fluctuation phenomena in nerve membrane. Proc. IEEE 56: 906–916.
White, M.W., Finley, C.C., and Wilson, B.S. (1987). Electrical stimulation model of the auditory nerve: Stochastic response characteristics. Proceedings of the Ninth Annual Conference of the IEEE Engineering in Medicine and Biology Society, Boston, pp. 1906–1907.
Wilson, B.S., and Finley, C.C. (1984). Speech processors for auditory prostheses. 2nd-4th Quarter Progress Reports. Contract NOl-NS-3-2356, NINCDS, NIH.
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Finley, C.C., Wilson, B.S., White, M.W. (1990). Models of Neural Responsiveness to Electrical Stimulation. In: Miller, J.M., Spelman, F.A. (eds) Cochlear Implants. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3256-8_5
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DOI: https://doi.org/10.1007/978-1-4612-3256-8_5
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