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Aplastic Anemia and Other Bone Marrow Failure Syndromes pp 63–81Cite as

Cellular Interactions in the Suppression of Hematopoiesis

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Abstract

It is well established that the complex series of events leading to the production of adequate numbers of mature blood cells is regulated by humoral and cell-mediated events that normally function to maintain blood cell numbers within very narrow limits.1–6 Significant changes in the rate of production of blood cells can occur when the rate of synthesis of the regulatory humoral factor(s) is altered. This is clearly demonstrated by the increased circulating red cell mass in individuals producing elevated levels of erythropoietin (Ep) when subjected to hypoxia,7 and by the anemia present in renoprival patients with decreased Ep production.8 A direct association between altered cell-mediated events and hematopoiesis in vivo has not been clearly established.

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Authors
  1. F. Roy MacKintosh
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  2. Jean C. Schulman
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  3. Esmail D. Zanjani
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Editors and Affiliations

  1. Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, 53792, USA

    Nasrollah T. Shahidi

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Roy MacKintosh, F., Schulman, J.C., Zanjani, E.D. (1990). Cellular Interactions in the Suppression of Hematopoiesis. In: Shahidi, N.T. (eds) Aplastic Anemia and Other Bone Marrow Failure Syndromes. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3254-4_5

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  • DOI: https://doi.org/10.1007/978-1-4612-3254-4_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7935-8

  • Online ISBN: 978-1-4612-3254-4

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