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Acquired Aplastic Anemia: Classification and Etiologic Considerations

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Book cover Aplastic Anemia and Other Bone Marrow Failure Syndromes

Abstract

Acquired aplastic anemia is an anatomic and physiologic failure of the bone marrow leading to pancytopenia. While occasionally the pancytopenia may be associated with a normocellular bone marrow, in the vast majority of the cases, the bone marrow is hypoplastic and pancytopenia is pronounced. The aplastic anemia is referred to as severe when, in addition to a hypoplastic bone marrow (less than 25% cellularity), at least two of the following three conditions are present: polymorphonuclear leukocyte count <500/µl, platelet count <20 X 103/µl, and anemia with a reticulocyte count (corrected for hematocrit) of less than 1%.

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Authors
  1. N. T. Shahidi
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Editors and Affiliations

  1. Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, 53792, USA

    Nasrollah T. Shahidi

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Shahidi, N.T. (1990). Acquired Aplastic Anemia: Classification and Etiologic Considerations. In: Shahidi, N.T. (eds) Aplastic Anemia and Other Bone Marrow Failure Syndromes. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3254-4_2

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  • DOI: https://doi.org/10.1007/978-1-4612-3254-4_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7935-8

  • Online ISBN: 978-1-4612-3254-4

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