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Diagnostic Advances in Anatomical and Functional Brain Imaging in Schizophrenia

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Recent Advances in Schizophrenia

Abstract

The past decade has experienced an unprecedented advance in our understanding of psychiatric disorders. This has led to renewed optimism and excitement in psychiatry in general and in schizophrenia research in particular. The optimism stems primarily from developments in the basic neurosciences and computer technology as well as from refinements that have been made in established psychiatric research areas such as epidemiology and phenomenology.

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References

  1. Phelps ME, Mazziotta JC: Positron emission tomography: human brain function and biochemistry. Science 1985;228: 799–809.

    Article  PubMed  CAS  Google Scholar 

  2. Jacobi W, Winkler H: Encephalographische studien an chronischen schizophrenen. Arch Psychiatr Nervenkr 1927;81:299–332.

    Article  Google Scholar 

  3. LeMay M: Changes in ventricular size during and after pneumoencephalography. Radiology 1967;88:57–63.

    PubMed  Google Scholar 

  4. Johnstone EC, Frith CD, Crow TJ, et al: Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 1976;ii:924–926.

    Article  Google Scholar 

  5. Jernigan TL, Zatz LM, Moses JA, et al: Computed tomography in schizophrenics and normal volunteers: I. Fluid volume. Arch Gen Psychiatry 1982;39:765–770.

    CAS  Google Scholar 

  6. Reveley MA: Ventricular enlargement in schizophrenia: the validity of computerised tomographic findings. Br J Psychiatr 1985;147:233–240.

    Article  CAS  Google Scholar 

  7. Weinberger DR, Torrey EF, Neophytides AN, et al: Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 1979;36:735–739.

    PubMed  CAS  Google Scholar 

  8. Glück E, Radu EW, Mundt C, et al: A computed tomographic protective trohoc study of chronic schizophrenics. Neuroradiology 1980;20:167–171.

    Article  PubMed  Google Scholar 

  9. Moriguchi I: A study of schizophrenic brains by computerized tomography scans. Folia Psychiatrica et Neurologica Japonica 1981;35:55–72.

    PubMed  CAS  Google Scholar 

  10. Pearlson GD, Veroff AE: Computerised tomographic scan changes in manic-depressive illiness. Lancet 1981;ii:470.

    Article  Google Scholar 

  11. Takahashi R, Inaba Y, Inanaga K, et al: CT scanning and the investigation of schizophrenia. Biol Psychiatry 1981;9:259–268.

    Google Scholar 

  12. Tanaka Y, Hazama H, Kawahara R, et al: Computerized tomography of the brain in schizophrenic patients. Acta Psychiatr Scand 1981;63: 191–197.

    Article  PubMed  CAS  Google Scholar 

  13. Weinberger DR, DeLisi LE, Neophytides AN, et al: Familial aspects of CT scan abnormalities in chronic schizophrenic patients. Psychiatry Res 1981;4:65–71.

    Article  PubMed  CAS  Google Scholar 

  14. Andreasen NC, Smith MR, Jacoby CG, et al: Ventricular enlargement in schizophrenia: definition and prevalence. Am J Psychiatry 1982; 139:292–296.

    PubMed  CAS  Google Scholar 

  15. Benes F, Sunderland P, Jones BD, et al: Normal ventricles in young schizophrenics. Br J Psychol 1982;141:90–93.

    Article  CAS  Google Scholar 

  16. Nasrallah HA, Jacoby CG, McCalley-Whitters M, et al: Cerebral ventricular enlargement in subtypes of chronic schizophrenia. Arch Gen Psychiatry 1982;39:774–777.

    PubMed  CAS  Google Scholar 

  17. Nyback H, Wiesel F-A, Berggren B-M, et al: Computed tomography of the brain in patients with acute psychosis and in healthy volunteers. Acta Psychiatr Scand 1982;65:403–414.

    Article  PubMed  CAS  Google Scholar 

  18. Okasha A, Madkour O: Cortical and central atrophy in chronic schizophrenia: a controlled study. Acta Psychiatr Scand 1982;65:29–34.

    Article  PubMed  CAS  Google Scholar 

  19. Reveley AM, Clifford CA, Reveley MA, et al: Cerebral ventricular size in twins discordant for schizophrenia. Lancet 1982;i:540–541.

    Article  Google Scholar 

  20. Weinberger DR, DeLisi LE, Perman GP, et al: Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Arch Gen Psychiatry 1982;39:778–783.

    PubMed  CAS  Google Scholar 

  21. Bishop RJ, Golden CJ, MacInnes WD, et al: The BPRS in assessing symptorn correlates of cerebral ventricular enlargement in acute and chronic schizophrenia. Psychiatry Res 1983;9:225–231.

    Article  PubMed  CAS  Google Scholar 

  22. Kling AS, Kurtz N, Tachiki K, et al: CT scans in sub-groups of chronic schizophrenics. J Psychiatr Res 1983;17:375–384.

    Article  CAS  Google Scholar 

  23. Schulz SC, Koller MM, Kishore PR, et al: Ventricular enlargement in teenage patients with schizophrenia spectrum disorder. Am J Psychiatry 1983;140:1592–1595.

    PubMed  CAS  Google Scholar 

  24. Woods BT, Wolf J: A reconsideration of the relation of ventricular enlargement to duration of illness in schizophrenia. Am J Psychiatry 1983;140:1564–1570.

    PubMed  CAS  Google Scholar 

  25. Largen JW, Smith RC, Calderon M, et al: Abnormalities of brain structure and density in schizophrenia. Biol Psychiatry 1984;19:991–1013.

    PubMed  Google Scholar 

  26. Luchins DJ, Lewine RRJ, Meltzer HY: Lateral ventricular size, psychopathology, and medication response in the psychoses. Biol Psychiatry 1984;19:29–44.

    PubMed  CAS  Google Scholar 

  27. DeMeyer MK, Gilmore R, DeMeyer WE, et al: Third ventricle size and ventricular brain ratio in treatment-resistant psychiatric patients. J Operational Psychiatry 1984;15:2–8.

    Google Scholar 

  28. Pandurangi AK, Dewan MJ, Lee SH, et al: The ventricular system in chronic schizophrenic patients: a controlled computed tomography study. Br J Psychiatr 1984;144:172–176.

    Article  CAS  Google Scholar 

  29. Pearlson GD, Garbacz DJ, Breakey WR, et al: Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Res 1984;12:1–9.

    Article  PubMed  CAS  Google Scholar 

  30. Andreasen NC: CT scan data in male and female schizophrenics. Abstracts, American Psychiatric Association Annual Meeting, 1984.

    Google Scholar 

  31. Carr EG, Wedding D: Neuropsychological assessment of cerebral ventricular size in chronic schizophrenics. Int J Clin Neuropsychol 1984;6:106–111.

    Google Scholar 

  32. Schulsinger F, Parnas J, Petersen ET, et al: Cerebral ventricular size in the offspring of schizophrenic mothers. Arch Gen Psychiatry 1984;41:602–606.

    PubMed  CAS  Google Scholar 

  33. Boronow J, Pickar D, Ninan PT, et al: Atrophy limited to the third ventricle in chronic schizophrenic patients. Arch Gen Psychiatry 1985;42:266–271.

    PubMed  CAS  Google Scholar 

  34. DeLisi LE, Goldin LR, Hamovit JR, et al: Cerebral ventricular enlargement as a possible genetic marker for schizophrenia. Psychopharmacol Bull 1985;21:365–367.

    Google Scholar 

  35. Kemali D, Maj M, Galderisi S, et al: Clinical and neuropsychological correlates of cerebral ventricular enlargement in schizophrenia. J Psychiatr Res 1985;19:587–596.

    Article  PubMed  CAS  Google Scholar 

  36. King DJ, Cooper SJ, Earle JAP, et al: Serum and CSF antibody titres to seven common viruses in schizophrenic patients. Br J Psychiatr 1985;147:145–149.

    Article  CAS  Google Scholar 

  37. Owens DGC, Johnstone EC, Crow TJ, et al: Lateral ventricular size in schzophrenia: relationship to the disease process and its clinical manifestations. Psychol Med 1985;15:27–41.

    Article  PubMed  CAS  Google Scholar 

  38. Shima S, Kanba S, Masuda Y, et al: Normal ventricles in chronic schizophrenics. Acta Psychiatr Scand 1985;71:25–29.

    Article  PubMed  CAS  Google Scholar 

  39. Williams AO, Reveley MA, Kolakowska T, et al: Schizophrenia with good and poor outcome. II: Cerebral ventricular size and its clinical significance. Br J Psychiatr 1985;146:239–246.

    Article  CAS  Google Scholar 

  40. Losonczy MF, Song IS, Mohs RC, et al: Correlates of lateral ventricular size in chronic schizophrenia, I: Behavioral and treatment response measures. Am J Psychiatry 1986;143:976–981.

    PubMed  CAS  Google Scholar 

  41. Obiols-Llandrich JE, Ruscalleda J, Masferrer M: Ventricular enlargement in young chronic schizophrenics. Acta Psychiatr Scand 1986;73:42–44.

    Article  PubMed  CAS  Google Scholar 

  42. Turner SW, Toone BK, Brett-Jones JR: Computerized tomographic scan changes in early schizophrenia—preliminary findings. Psychol Med 1986;16:219–225.

    Article  PubMed  CAS  Google Scholar 

  43. Rabins P, Pearlson G, Jayaram G, et al: Increased ventricle-to-brain ratio in late-onset schizophrenia. Am J Psychiatry 1987;144:1215–1218.

    Google Scholar 

  44. Romani A, Merello S, Gozzoli L, et al: P300 and CT scan patients with chronic schizophrenia. Br J Psychiatr 1987;151:506–513.

    Article  CAS  Google Scholar 

  45. Rossi A, de Cataldo S, Stratta P, et al: Cerebral atrophy and neuropsychological correlates in schizophrenia. Acta Psychiat Belg 1987;87:670–675.

    CAS  Google Scholar 

  46. Iacono WG, Smith GN, Moreau M, et al: Ventricular and sulcal size at the onset of psychosis. Am J Psychiatry 1988;145:820–824.

    PubMed  CAS  Google Scholar 

  47. Rossi A, Stratta P, de Cataldo S, et al: Cortical and subcortical computed tomographic study in schizophrenia. J Psychiat Res 1988;22:99–105.

    Article  PubMed  CAS  Google Scholar 

  48. Shelton RC, Karson CN, Doran AR, et al: Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect. Am J Psychiatry 1988;145:154–163.

    PubMed  CAS  Google Scholar 

  49. Wolkin A, Angrist B, Wolf A, et al: Low frontal glucose utilization in chronic schizophrenia: a replication study. Am J Psychiatry 1988;145:251–253.

    PubMed  CAS  Google Scholar 

  50. Pfefferbaum A, Zipursky RB, Lim KO, et al: Computed tomographic evidence for generalized sulcal and ventricular enlargement in schizophrenia. Arch Gen Psychiatry 1988;45:633–640.

    PubMed  CAS  Google Scholar 

  51. Stevens JR: Neuropathology of schizophrenia. Arch Gen Psychiatry 1982;39:1131–1139.

    PubMed  CAS  Google Scholar 

  52. Benes FM, Davidson J, Bird ED: Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch Gen Psychiatry 1986;43:31–35.

    PubMed  CAS  Google Scholar 

  53. Jacobson RR, Turner SW, Baldy RD, et al: Densitometric analysis of scans: important sources of artefact. Psychol Med 1985;15:879–889.

    Article  PubMed  CAS  Google Scholar 

  54. Swayze II VW, Yates WR, Andreasen NC, et al: CT abnormalities in tardive dyskinesia. Psychiatry Res 1988;26:51–58.

    Article  PubMed  Google Scholar 

  55. Donnelly EF, Weinberger DR, Waldman IN, et al: Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients. J Nerv Ment Dis 1980;168:305–308.

    Article  PubMed  CAS  Google Scholar 

  56. Kolakowska T, Williams AO, Jambor K, et al: Schizophrenia with good and poor outcome, III: Neurological ‘soft’ signs, cognitive impairment and their clinical significance. Br J Psychiatr 1985;146:348–357.

    Article  CAS  Google Scholar 

  57. Weinberger DR, Cannon-Spoor E, Potkin SG, et al: Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. Am J Psychiatry 1980;137:1410–1413.

    PubMed  CAS  Google Scholar 

  58. van Kammen DP, Mann LS, Sternberg DE, et al: Dopamine-β-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy. Science 1983;220:974–977.

    Article  PubMed  Google Scholar 

  59. van Kammen DP, Mann LS, Scheinin M, et al: Spinal fluid monoamine metabolites and anticytomegalovirus antibodies and brain scan evaluation in schizophrenia. Psychopharmacol Bull 1984;20:519–522.

    PubMed  Google Scholar 

  60. Potkin SG, Weinberger DR, Linnoila M, et al: Low CSF 5-hydroxyindoleacetic acid in schizophrenic patients with enlarged cerebral ventricles. Am J Psychiatry 1983;140:21–25.

    PubMed  CAS  Google Scholar 

  61. Nyback H, Berggren B-M, Hindmarsh T, et al: Cerebroventricular size and cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy volunteers. Psychiatry Res 1983;9:301–308.

    Article  PubMed  CAS  Google Scholar 

  62. Jaskiw GE, Andreasen NC, Weinberger DR: X-ray computed tomography and magnetic resonance imaging in psychiatry, in Hales RE, Frances AJ (eds): American Psychiatric Association Annual Review, vol. 6. Washington, DC, American Psychiatric Press, Inc., 1987, pp 260–299.

    Google Scholar 

  63. Nasrallah HA, Olson SC, McCalley-Whitters M, et al: Cerebral ventricular enlargement in schizophrenia. Arch Gen Psychiatry 1986;43:157–159.

    PubMed  CAS  Google Scholar 

  64. Illowsky BP, Juliano DM, Bigelow LB, et al: Stability of CT scan findings in schizophrenia: results of an 8-year follow-up study. J Neurol Neurosurg Psychiatry 1988;51:209–213.

    Article  PubMed  CAS  Google Scholar 

  65. Brant-Zawadski M, Norman D (eds): Magnetic Resonance Imaging of the Central Nervous System. New York, Raven Press, 1987.

    Google Scholar 

  66. Oldendorf W, Oldendorf Jr W: Basics of magnetic resonance imaging. Hingham, MA, Martinus Nijhoff, 1988, pp 1–180.

    Google Scholar 

  67. Johnstone EC, Crow TJ, Macmillan JF, et al: A magnetic resonance study of early schizophrenia. J Neurol Neurosurg Psychiatry 1986;49:136–139.

    Article  PubMed  CAS  Google Scholar 

  68. Smith RC, Calderon M, Ravichandran GK, et al: Nuclear magnetic resonance in schizophrenia: a preliminary study. Psychiatry Res 1984;12:137–147.

    Article  PubMed  CAS  Google Scholar 

  69. Mathew RJ, Partain CL: Midsagittal sections of the cerebellar vermis and fourth ventricle obtained with magnetic resonance imaging of schizophrenic patients. Am J Psychiatry 1985;142:970–971.

    PubMed  CAS  Google Scholar 

  70. Mathew RJ, Partain CL, Prakash R, et al: A study of the septum pellucidum and corpus callosum in schizophrenia with MR imaging. Acta Psychiatr Scand 1985;72:414–421.

    Article  PubMed  CAS  Google Scholar 

  71. Andreasen NC, Nasrallah HA, Dunn VD, et al: Structural abnormalities in the frontal system in schizophrenia: a magnetic resonance imaging study. Arch Gen Psychiatry 1986;43:136–144.

    PubMed  CAS  Google Scholar 

  72. Nasrallah HA, Andreasen NC, Coffman JA, et al: A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biol Psychiatry 1986;21:274–282.

    Article  PubMed  CAS  Google Scholar 

  73. Smith RC, Baumgartner R, Calderon M: Magnetic resonance imaging studies of the brains of schizophrenic patients. Psychiatry Res 1987;20:33–46.

    Article  PubMed  CAS  Google Scholar 

  74. Rossi A, Stratta P, Gallucci M, et al: Standardized magnetic resonance image intensity study in schizophrenia. Psychiatry Res 1988;25:223–231.

    Article  PubMed  CAS  Google Scholar 

  75. Kelsoe JR, Cadet JL, Pickar D, et al: Quantitative neuroanatomy in schizophrenia. Arch Gen Psychiatry 1988;45:533–541.

    PubMed  Google Scholar 

  76. DeMyer MK, Gilmor RL, Hendrie HC, et al: Magnetic resonance brain images in schizophrenic and normal subjects: influence of diagnosis and education. Schizophr Bull 1988;14:21–37.

    Google Scholar 

  77. Andreasen NC, Ehrhardt JC, Swayze VW, et al: Magnetic resonance imaging of the brain in schizophrenia: pathophysiological significance of structural abnormalities. Arch Gen Psychiatry 1989, in press.

    Google Scholar 

  78. Besson JAO, Corrigan FM, Cherryman GR, et al: Nuclear magnetic resonance brain imaging in chronic schizophrenia Br J Psychiatr 1987;150:161–163.

    CAS  Google Scholar 

  79. Andreasen NC, Ehrhardt JC, Swayze VW, et al: T1 and T2 relaxation times in schizophrenia as measured with magnetic resonance imaging. Arch Gen Psychiatry 1989, in press.

    Google Scholar 

  80. Roy CS, Sherrington CS: The regulation of the blood supply of the brain. J Physiol 1890;11:85–121.

    PubMed  CAS  Google Scholar 

  81. Kety SS, Woodford RB, Harmel MH, et al: Cerebral blood flow and metabolism in schizophrenia: the effects of barbiturate seminarcosis, insulin coma and electroshock. Am J Psychiatry 1948;104:765–770.

    PubMed  CAS  Google Scholar 

  82. Ingvar DH: “Hyperfrontal” distribution of the cerebral grey matter flow in resting wakefulness; on the functional anatomy of the conscious state. Acta Neurol Scandinav 1979;50:425–462.

    Article  Google Scholar 

  83. Ingvar DH, Franzen G: Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 1974;50:425–462.

    Article  PubMed  CAS  Google Scholar 

  84. Berman KF, Zee RF, Weinberger DR: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort. Arch Gen Psychiatry 1986;43:126–135.

    PubMed  CAS  Google Scholar 

  85. Shirahata N, Henriksen L, Vorstrup S, et al: Regional cerebral blood flow assessed by 133Xe inhalation and emission tomography: normal values. J Comput Assist Tomogr 1985;9:861–866.

    Article  PubMed  CAS  Google Scholar 

  86. Devous MD: Imaging brain function by single photon emission computer tomography in Andreasen NC (ed): Brain Imaging: Applications in Psychiatry. American Psychiatric Press, Inc., 1989.

    Google Scholar 

  87. Reivich M, Kuhl D, Wolf A: The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 1979;44:127–137.

    PubMed  CAS  Google Scholar 

  88. Sokoloff L, Reivich M, Kennedy C: The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization theory, procedure, and moral values in the conscious and anesthetized albino rat. J Neurochem 1977;28:897–916.

    Article  PubMed  CAS  Google Scholar 

  89. Farkas T, Reivich M, Alavi A, et al: [18F]2-deoxy-2-fluoro-D-glucose and positron emission tomography in the study of psychiatric conditions, in Passonneau JV, Hawkins RA, Lust WD, Welsh FA (eds): Cerebral Metabolism and Neural Function. Baltimore/London, Williams & Wilkins, 1980, pp. 403–408.

    Google Scholar 

  90. Sheppard G, Gruyzelier J, Manchanda R, et al: 150 positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet 1983,24/31:1448–1452.

    Article  Google Scholar 

  91. Buchsbaum MS, Ingvar DH, Kessler R, et al: Cerebral glucography with positron tomography. Use in normal subjects and in patients with schizophrenia. Arch Gen Psychiatry 1982;39:251–259.

    PubMed  CAS  Google Scholar 

  92. Farkas T, Wolf AP, Jaeger J, et al: Regional brain glucose metabolism in chronic schizophrenia: a positron emission transaxial tomographic study. Arch Gen Psychiatry 1984;41:293–300.

    PubMed  CAS  Google Scholar 

  93. Widen L, Blomqvist G, Greitz T, et al: PET studies of glucose metabolism in patients with schizophrenia. AJNR 1983;4:550–552.

    PubMed  CAS  Google Scholar 

  94. Wolkin A, Jaeger J, Brodie JD, et al: Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. Am J Psychiatry 1985;142:564–571.

    PubMed  CAS  Google Scholar 

  95. Jernigan TL, Sargent T, Pfefferbaum A, et al: 18Fluorodeoxyglucose PET in schizophrenia. Psychiatry Res 1985;16:317–329.

    Article  PubMed  CAS  Google Scholar 

  96. Gur RE, Resnick SM, Alavi A, et al: Regional brain function in schizophrenia. I. A positron emission tomography study. Arch Gen Psychol 1987;44:119–125.

    CAS  Google Scholar 

  97. Gur RE, Resnick SM, Gur RC, et al: Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Arch Gen Psychiatry 1987;44:126–129.

    PubMed  CAS  Google Scholar 

  98. Kling AS, Metter EJ, Riege WH, et al: Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. Am J Psychiatry 1986;143:175–180.

    PubMed  CAS  Google Scholar 

  99. Volkow ND, Brodie JD, Wolf AP, et al: Brain organization in schizophrenia. J Cereb Blood Flow Metab 1986;6:441–446.

    Article  PubMed  CAS  Google Scholar 

  100. Williamson P: Hypofrontality in schizophrenia: a review of the evidence. Can J Psychiatry 1987;32:399–404.

    PubMed  CAS  Google Scholar 

  101. Mazziotta JC, Phelps ME, Kuhl DE: Quantitation in positron emission computed tomography. 5. Physical-anatomical effects. J Comput Assist Tomogr 1981;5:734–43.

    Article  PubMed  CAS  Google Scholar 

  102. Seeman P: Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1987;1:133–152.

    Article  PubMed  CAS  Google Scholar 

  103. Wong DF, Wagner HN, Tune LE, et al: Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 1986;234:1558–1563.

    Article  PubMed  CAS  Google Scholar 

  104. Farde L, Hall H, Ehrin E, et al: Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science 1986;231:258–261.

    Article  PubMed  CAS  Google Scholar 

  105. Farde L, Wiesel FA, Halldin C, et al: Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 1988;45:71–76.

    PubMed  CAS  Google Scholar 

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Authors
  1. Jörg J. Pahl
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  2. Victor W. Swayze
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  3. Nancy C. Andreasen
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Pahl, J.J., Swayze, V.W., Andreasen, N.C. (1990). Diagnostic Advances in Anatomical and Functional Brain Imaging in Schizophrenia. In: Recent Advances in Schizophrenia. International Perspectives Series: Psychiatry, Psychology, and Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3248-3_8

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  • DOI: https://doi.org/10.1007/978-1-4612-3248-3_8

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