Risk Factors in Schizophrenia: Interaction Between Genetic Liability and Environmental Factors

  • Fini Schulsinger
  • Josef Parnas
Part of the International Perspectives Series: Psychiatry, Psychology, and Neuroscience book series


This chapter does not focus strictly on the genetic liability for schizophrenia1 or the effects of environment in producing schizophrenia,2.3 but rather mainly on the interaction of genetic liabilities with experiential factors. This nature-nurture approach focuses on the degree of genetic risk and interactions with and effects of various environmental stressors.4 This is a relatively new field with few studies on these interactions.


Schizophrenic Patient Obstetrical Complication Genetic Liability Birth Complication Formal Thought Disorder 
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  1. 1.
    Gottesman II, Shields J: Schizophrenia and Genetics: a Twin Study Vantage Point. New York, Academic Press, 1972.Google Scholar
  2. 2.
    Gottesman II, Shields J: Rejoinder: toward optimal arousal and away from original din. Schiz Bull 1976;2:447–453.Google Scholar
  3. 3.
    Lidz T, Fleck S, Cornelison A: Schizophrenia and the Family. New York, International University Press, 1965.Google Scholar
  4. 4.
    Schulsinger F, Parnas J, Schulsinger H, et al: Recent trends from nature- nurture research in schizophrenia, in Stefanis CN, Rabavilas AD (eds): Schizophrenia: Recent Biosocial Developments. New York, Human Sciences Press, Inc., 1988.Google Scholar
  5. 5.
    Schulz B: Zur Erbpathologic der Schizophrenen. Zeitschr ges Neurol und Psychiatr 1932; 143: 175–293.CrossRefGoogle Scholar
  6. 6.
    Bleuler M: Das Wesen der Schizophrenic nach Schockbehandlung. Zeitschr ges Neurol und Psychiatr 1941; 173:553–597.CrossRefGoogle Scholar
  7. 7.
    Pollin W, Stabenau JR: Biological, psychological, and historical differences in a series of monozygotic twins discordant for schizophrenia. J Psychiat Res 1968;6(suppl)(1):317–332.CrossRefGoogle Scholar
  8. 8.
    Kety SS, Rosenthal D, Wender PH, et al: The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics, in Rosenthan D, Kety SS (eds): The Transmission of Schizophrenia. Oxford, Pergamon, 1968, pp 345–362.Google Scholar
  9. 9.
    Kety SS, Rosenthal D, Wender PH, et al: Mental illness in the biological and adoptive relatives of adopted individuals who became schizophrenic, in Fieve R, Rosenthal D, Brill H (eds): Genetic Research in Psychiatry. Baltimore, MD, Johns Hopkins University Press, 1975.Google Scholar
  10. 10.
    Rosenthal D, Wender PH, Kety SS, et al: Schizophrenics’ offspring reared in adoptive homes, in Rosenthan D, Kety SS (eds): The Transmission of Schizophrenia. Oxford, Pergamon, 1968, pp 377–391.Google Scholar
  11. 11.
    Mednick SA, Schulsinger F: A longitudinal study of children with a high risk for schizophrenia: a preliminary report, in Vnderberg S, (ed): Methods and Goals in Human Behavior Genetics. New York, Academic Press, 1965.Google Scholar
  12. 12.
    Mednick SA, Schulsinger F: Studies of children at high risk for schizophrenia, in MSS Information Service (eds): Schizophrenia: The First Ten Dean Award Lectures. New York, MSS Information Service, 1973, pp 245–293.Google Scholar
  13. 13.
    Schulsinger H: A ten-year follow-up of children of schizophrenic mothers: clinical assessment. Acta Psychiatr Scand 1976;53:371.PubMedCrossRefGoogle Scholar
  14. 14.
    Parnas J, Schulsinger F, Teasdale TW, et al: Perinatal complications and clinical outcome within the schizophrenia spectrum. Br J Psychiatry 1982; 140:416–420.PubMedCrossRefGoogle Scholar
  15. 15.
    Parnas J, Schulsinger F, Schulsinger H, et al: Behavioral precursors of schizophrenia spectrum. Arch Gen Psychiatry 1982;39:658–664.PubMedGoogle Scholar
  16. 16.
    Schulsinger F, Parnas J, Petersen ET, et al: Cerebral ventricular size in the offspring of schizophrenic mothers: a preliminary study. Arch Gen Psychiatry 1984;41:602–606.PubMedGoogle Scholar
  17. 17.
    Parnas J, Teasdale TW, Schulsinger H: Institutional rearing and diagnostic outcome in children of schizophrenic mothers. Arch Gen Psychiatry 1985;42:762–769.PubMedGoogle Scholar
  18. 18.
    Parnas J: Mates of schizophrenic mothers: a study of associative reacting from the American-Danish High Risk Project. Br J Psychiatry 1985; 140:490–497.CrossRefGoogle Scholar
  19. 19.
    Rutter M: Maternal Deprivation Reassessed. Hammondworths, Penguin Books Ltd., 1981.Google Scholar
  20. 20.
    Mednick SA, Machon RA, Huttunen MO, et al: Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 1988; 45: 189–192.PubMedGoogle Scholar
  21. 21.
    Crow TJ: A re-evaluation of the viral hypothesis: is psychosis the result of retroviral integration at a site close to the cerebral dominance gene? Br J Psychiatry 1984; 145:243–253.PubMedCrossRefGoogle Scholar
  22. 22.
    Kraepelin E: Psychiatrie, ed 4. Leipzig, JA Barth, 1896.Google Scholar
  23. 23.
    Kraepelin E: Psychiatrie, ed 8. Leipzig, J A Barth, 1915.Google Scholar
  24. 24.
    Bleuler E: Dementia Praecox or the Group of Schizophrenias. New York, International University Press, 1911/1950.Google Scholar
  25. 25.
    Crow TJ: The continuum of psychosis and its implications for the structure of the gene. Br J Psychiatry 1986; 149:419–429.PubMedCrossRefGoogle Scholar
  26. 26.
    Claridge GS: The schizophrenia as nervous types revisited. Br J Psychiatry 1987; 151:735–743.PubMedCrossRefGoogle Scholar
  27. 27.
    Lancet: A continuum of psychosis? 1987;October:889–890.Google Scholar
  28. 28.
    Jaspers K: General Psychopathology. Chicago, University of Chicago Press, 1963.Google Scholar
  29. 29.
    Gottesman II, Shields J: Schizophrenia and Genetics: A Twin Study Vantage Point. New York, Academic Press, 1972.Google Scholar
  30. 30.
    Stransky E: Zur Kenntnis gewisser ervorbener Bloedsinnsformen. Neurologisches Zentralblatt 1903;24:1–149.Google Scholar
  31. 31.
    Meehl PE: Schizotaxia, schizotypy, schizophrenia. Am Psychol 1962; 17:827–838.CrossRefGoogle Scholar
  32. 32.
    Shields J, Heston LL, Gottesman II: Schizophrenia and the schizoid: the problem for genetic analysis, in Fieve RR, Rosenthal D, Brill H (eds): Genetic Research in Psychiatry. Baltimore, Johns Hopkins University Press, 1975, pp 167–198.Google Scholar
  33. 33.
    Gunderson JG, Siever LJ, Spaulding E: The search for a schizotype. Arch Gen Psychiatry 1983;40:15–22.PubMedGoogle Scholar
  34. 34.
    Torgersen S: Relationship of schizotypal personality disorder to schizophrenia: Genetics. Schizophr Bull 1985; 11:554–563.PubMedGoogle Scholar

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© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • Fini Schulsinger
  • Josef Parnas

There are no affiliations available

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