Abstract
Neutrophils adhere to endothelium by neutrophil-dependent or endothelial-dependent mechanisms (1). The neutrophil-dependent mechanism operates when the neutrophil is directly stimulated by activating agents such as bacterial chemotactic peptides, complement fragments, or tumor necrosis factor/cachectin (TNF). Neutrophil-dependent adherence is mediated by the interaction of neutrophil CD11b/CD18 (Mac-1, Mol) and endothelial intercellular adhesion molecule-1 (ICAM-1) (2).
Keywords
- Neutrophil Adherence
- Neutrophil Accumulation
- Endothelial Cell Surface
- Inflammatory Focus
- Human Vascular Endothelial Cell
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This work was supported by MRC of Canada 4219 and USPHS HL 30542. Dr. Doerschuk is the recipient of an American Lung Association Fellowship and an Edward Livingston Trudeau Scholar Award. Dr. Harlan is an Established Investigator of the American Heart Association.
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References
Schwartz BR, Harlan JM: Mechanisms of leukocyte adherence to endothelium, in Ryan US (ed): Endothelial Cells, Vol II. Boca Raton, FL, CRC Press, p. 213–226, 1988.
Smith CW, Rothlein R, Hughes B, Mariscalco M, Schmalstieg F, Anderson DC: Identification of an endothelial determinant for CD18-dependent neutrophil adherence. FASEB J 2:A 1237, 1988.
Zimmerman GA, McIntyre TM, Prescott SM: Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J Clin Invest 76:2235, 1985.
McIntyre TM, Zimmerman GA, Prescott SM: Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. Proc Natl Acad Sci USA 83:2204, 1986.
Zimmerman GA, Mclntyre TM: Neutrophil adherence to human endothelium in vitro occurs by CDw18 (Mol, Mac-1/LFA-1/GP150,95) glycoprotein-de-pendent and -independent mechanisms. J Clin Invest 81:531, 1988.
Schleimer, RP, Rutledge BK: Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin-1, endotoxin, and tumor-producing phorbol diesters. J Immunol 136:649, 1986.
Bevilacqua MP, Pober JS, Wheeler ME, Mendrick D, Cotran RS, Gimbrone MA, Jr: Interleukin-1 acts on cultured human vascular endothelial cells to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest 76:2003, 1985.
Gamble JR, Harlan JM, Klebanoff SJ, Lopez AF, Vadas MA: Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc Natl Acad Sci USA 82:8667, 1985.
Bevilacqua MP, Pober JS, Mendrick DL, Cotran RS, Gimbrone MA, Jr: Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci USA 84:9238, 1987.
Pohlman TH, Stanness KA, Beatty PG, Ochs HD, Harlan JM: An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin-1, and tumor necrosis factor-alpha increases neutrophil adherence by CDw18-dependent mechanism. J Immunol 136:4548, 1986.
Rampart M, Williams TJ: Evidence that neutrophil accumulation induced by interleukin-1 requires both local protein biosynthesis and neutrophil CD 18 antigen expression in vivo. Br J Pharmacol 94:1143, 1988.
Anderson DC, Springer TA: Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Ann Rev Med 38:175, 1987.
Todd, RF, Freyer DR: The CD11/CD18 leukocyte glycoprotein deficiency. Hematol Oncol Clin N Am 2:13, 1988.
Beatty PG, Ledbetter JA, Martin PG, Price TH, Hansen JA: Definition of a common leukocyte cell-surface antigen (Lp95–150) associated with diverse cell-mediated immune functions. J Immunol 131:2913, 1983.
Arfors K-E, Lundberg C, Lindbom L, Lundberg K., Beatty PG, Harlan JM: A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma protein leakage in vivo. Blood 69:338, 1987.
Price TH, Beatty PG, Corpuz SR: In vivo inhibition of neutrophil function in the rabbit using monoclonal antibody to CD 18. J Immunol 12:4174, 1987.
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Doerschuk, C.M., Winn, R.K., Harlan, J.M. (1990). Mechanisms of Neutrophil Emigration. In: Springer, T.A., Anderson, D.C., Rothlein, R., Rosenthal, A.S. (eds) Leukocyte Adhesion Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3234-6_6
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DOI: https://doi.org/10.1007/978-1-4612-3234-6_6
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