Abstract
Immunosuppression with heterologous antibodies directed against human T lymphocytes has been investigated in human allograft recipients for more than 20 years. Polyclonal preparations (e.g., ATG and ALG) were initially the only agents available. Because of their unquestioned efficacy, these agents remain an important part of the clinical armamentarium in spite of the continuing difficulties encountered when trying to produce consistent batches of antisera with predictable immunosuppressive potency. The more recent development of monoclonal antibodies (MAbs) reactive with human T-cell-specific surface determinants has provided a more refined approach to the prevention or treatment of allograft rejection episodes (1). The most widely studied MAb in clinical protocols has been the pan-T-cell reactive OKT3. As with most heterologous anti-sera that have been clinically effective, the immunosuppression achieved following administration has been attributed to T cell depletion, and, in the case of OKT3, modulation of the CD3 molecule.
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References
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Cosimi, A.B., Geoffrion, C., Anderson, T., Conti, D., Rothlein, R., Colvin, R.B. (1990). Immunosuppression of Cynomolgus Recipients of Renal Allografts by R6.5, a Monoclonal Antibody to Intercellular Adhesion Molecule-1. In: Springer, T.A., Anderson, D.C., Rothlein, R., Rosenthal, A.S. (eds) Leukocyte Adhesion Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3234-6_23
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DOI: https://doi.org/10.1007/978-1-4612-3234-6_23
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