Abstract
Unlike solid organs, in which cell-cell contacts are largely established during morphogenesis, cells of the immune system are mobile and their contacts with other cells are transient ones. The ability to establish transient contacts with other cells is critical to the function of essentially all leukocytes. Cell-cell contact is critical to the function of mature circulating T lymphocytes both in the induction of their responses (e.g., by T cell interaction with an accessory cell) and in the effector arm of their responses (e.g., T cells providing help for B cells or effecting cell-mediated cytotoxicity). Our interest in T lymphocyte adhesion derives from commitment to understanding cytotoxic T lymphocyte (CTL) recognition and to a growing certainty that T cell adhesion is a complex and poorly understood process which is critical to CTL recognition. Although our studies emphasize the relevance of adhesion to CTL, it is apparent that other T cell responses must be similarly dependent on cell-cell adhesion. It is pointless to duplicate in detail recent reviews dealing with many of the important issues in T cell adhesion [1–5]. Instead, we will focus primarily on discussion of the importance of antigen-independent adhesion in T cell recognition.
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Shaw, S., Makgoba, M.W., Shimizu, Y. (1990). Antigen-Independent Adhesion: A Critical Process in Human Cytotoxic T Cell Recognition. In: Springer, T.A., Anderson, D.C., Rothlein, R., Rosenthal, A.S. (eds) Leukocyte Adhesion Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3234-6_19
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DOI: https://doi.org/10.1007/978-1-4612-3234-6_19
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