Specificity and Regulation of CD18-Dependent Adhesions
The ability of polymorphonuclear leukocytes (PMN) to adhere to other cells and substrates is under strict physiological regulation. This is best illustrated by considering PMN circulating within the vasculature. These cells show negligible affinity for the endothelial cells (EC) which surround them. When PMN encounter chemotactic factors this situation is rapidly altered, and the adhesion of PMN to EC is dramatically enhanced. In normal circumstances, stimulated PMN soon break their adhesion to EC and either return to the circulation or leave the vasculature by diapedesis. Thus, PMN possess the means of transiently making then breaking adhesion to EC and other substrates in response to specific stimuli.
KeywordsLysine Interferon Arginine Prostaglandin Meningitis
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