Abstract
The molecules on the leukocyte cell surface that are partially responsible for the adherence to cellular substrates have been identified as members of the LFA-1/MAC-1 family of adhesion molecules or the CD18 complex (reviewed in 1–3). A group of patients has been identified (leukocyte adherence deficiency, LAD) whose leukocytes do not express the CD18 complex on their surfaces and are unable to perform normally in in vitro, adhesion-dependent, leukocyte functional assays (4–9). The role of the CD18 complex in mediating leukocyte adhesion is confirmed when one observes that the same in vitro adhesion-related defects found in neutrophils from LAD patients are seen in leukocytes from normal individuals when they are assayed in the presence of anti-CD 18 complex antibodies (3,10–15).
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References
Martz E: Mechanism of specific tumor cell lysis by alloimmune T-lymphocytes: Resolution and characterization of discrete steps in the cellular interactions. Human Immunol 18:3, 1977.
Springer TA, Dustin ML, Kishimoto TK, Marlin SD: The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: Cell adhesion receptors of the immune system. Ann Rev Immunol 5:223, 1987.
Anderson DC, Miller LJ, Schmalstieg FC, Rothlein R, Springer TA: Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: Structure-function assessment employing subunit-specific monoclonal antibodies. J Immunol 137:15, 1986.
Anderson DC, Springer TA: Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Ann Rev Med 38:175, 1987.
Crowley CA, Curnutte JT, Rosin RE, Andre-Schwartz J, Gallin JI, Klempner M, Synderman R, Southwick FS, Stossel TP, Babior BM: An inherited abnormality of neutrophil adhesion: Its genetic transmission and its association with a missing protein. New Eng J Med 302:1163, 1980.
Anderson DC, Schmalstieg FC, Arnaout MA, Kohl S, Tosi MF, Dana N, Buffone GJ, Hughes BJ, Brinkley BR, Dickery WD, Abrahamson JS, Springer T, Boxer LA, Hollers JM, Smith CW: Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): Common relationship to diminished cell adherence. J Clin Invest 74:536, 1984.
Dana N, Todd III RF, Pitt J, Springer TA, Arnaout MA: Deficiency of a surface membrane glycoprotein (Mol) in man. J Clin Invest 73:153, 1984.
Beatty PG, Ochs HD, Harlan JM, Price TD, Rosen H, Taylor RF, Hansen JA, Klebanoff SJ: Absence of monoclonal-antibody-defined protein complex in a boy with abnormal leukocyte function. Lancet 1:535, 1984.
Fischer A, Seger R, Durandy A, Grospierre B, Virelizier JL, LeDeist F, Griscelli C, Fischer E, Kazatchkine M, Bohler MC, Descamps-Latscha B, Trung PH, Springer TA, Olive R, Mawas C: Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor 3, glycoprotein p150,95 in a girl with recurrent bacterial infection. J Clin Invest 76:2385, 1985.
Davignon D, Martz E, Reynolds T, Kurzinger K, Springer TA: Lymphocyte function-associated antigen 1 (LFA-1): Surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing. Proc Natl Acad Sci USA 78:4535, 1981.
Kohl S, Springer TA, Schmalstieg FC, Loo LS, Anderson DC: Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency. J Immunol 133:2972, 1984.
Buescher ES, Gaither T, Nath J, Gallin JI: Abnormal adherence-related functions of neutrophils, monocytes, and Epstein-Barr virus-transformed B cells in a patient with C3bi receptor deficiency. Blood 65:1382, 1985.
Rothlein R, Springer TA: The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester. J Exp Med 163:1132, 1986.
Tonnesen, MG, Anderson DC, Springer TA, Knedler A, Avdi N, Henson PM: Mac-1 glycoprotein family mediates adherence of neutrophils to endothelial cells stimulated by chemotactic peptides. Clin Res 34:419a, 1986.
Harlan JM, Killen PD, Senecal FM, Schwartz BR, Yee EK, Taylor RF, Beatty PG, Price TH, Ochs HD: The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro. Blood 6:167, 1985.
Rothlein R, Dustin ML, Marlin SD, Springer TA: A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137:1270, 1986.
Dustin ML, Rothlein R, Bahn AK, Dinarello CA, Springer TA: Induction by IL-1 and Interferon-gamma: Tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 137:245, 1986.
Pober JS, Gimbrone MA, Lapierre LA, Mendrick DL, Fiere W, Rothlein R, Sprinter TA: Overlapping patterns of activation of human endothelial cells by interleukin-1, tumor necrosis factor and immune interferon. J Immunol 137:1893, 1986.
Lange Vejlsgaard G, Ralfkiaer E, Avnstorp C, Czajkowski M, Marlin SD, Rothlein R: Kinetics and characterization of intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes in various inflammatory skin lesions and malignant cutaneous lymphomas. J Am Acad Dermatol 20:782, 1989.
Smith CW, Rothlein R, Hughes BJ, Mariscalco MM, Schmalsteig FC, Anderson DC: Recognition of an endothelial determinant for CD18-dependent human neutrophil adherence and transendothelial migration. J Clin Invest 82:1746, 1988.
Galfre AG, Secher DS, Milstein C: Mac-1: A macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol 9:301, 1979.
McCall CE, Taylor RG, Cousart SL, Woodruff RD, Lewis JC, O’Flaherty JT: Pulmonary injury induced by phorbol myristate acetate following intravenous administration in rabbits: Acute respiratory distress followed by pulmonary interstitial pneumonitis and pulmonary fibrosis. Am J Pathol 111:258, 1983.
Taylor RG, McCall CE, Thrall RS, Woodruff RD, O’Flaherty JT: Histopathologic features of phorbol myristate acetate-induced lung injury. Lab Invest 52:61, 1985.
Price TH, Beatty PG, Corpuz SR: In vivo inhibition of neutrophil function in the rabbit using monoclonal antibody to CD18. J Immunol 139:4174, 1987.
Arfors K-E, Lundberg C, Lindbom L, Lundberg K, Beatty PG, and Harlan JM: A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo. Blood 69:338, 1987.
Vedder NB, Winn RK, Rice CL, Chi EY, Arfors K-E, Harlan JM: A monoclonal antibody to the adherence-promoting leukocyte glycoprotein CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. J Clin Invest 81:939, 1988.
Simpson PJ, Todd III RF, Fantone JC, Mickelson JK, Griffen JD, Lucchesi BR: Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mol, anti-CD11b) that inhibits leukocyte adhesion. J Clin Invest 81:624, 1988.
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Barton, R.W., Rothlein, R., Ksiazek, J., Kennedy, C. (1990). Role of Anti-Adhesion Monoclonal Antibodies in Rabbit Lung Inflammation. In: Springer, T.A., Anderson, D.C., Rothlein, R., Rosenthal, A.S. (eds) Leukocyte Adhesion Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3234-6_12
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DOI: https://doi.org/10.1007/978-1-4612-3234-6_12
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