Abstract
Considerable evidence exists that red blood cells (RBC) are oxidatively damaged in vivo.1–10 Since these cells have limited ability to repair such damage, the cumulative injury resulting from oxidation can contribute to cell death. In red cells characterized by congenital or acquired structural defects, susceptibility to oxidant injury is often increased.2 However, the extent to which oxidant injury contributes to shortened survival of these RBC is not clearly determined. We will discuss factors that render the red cell susceptible to oxidant injury, review several clinical disorders in which red cell oxidant injury has been reported, and provide a rationale for designing therapies to prevent oxidative damage.
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Lubin, B., Kuypers, F., Vichinsky, E., Chiu, D. (1990). The Role of Oxidation in Diseases of the Human Erythrocyte. In: Pomerance, H.H., Bercu, B.B. (eds) Topics in Pediatrics. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3230-8_5
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DOI: https://doi.org/10.1007/978-1-4612-3230-8_5
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