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The Pathogenesis of Immunologically Mediated Diabetes

  • Yi Wang
  • Liming Hao
  • Kevin J. Lafferty
Part of the Endocrinology and Metabolism book series (EAM, volume 4)

Abstract

Diabetes as a pathologic entity has been with us as long as recorded medical history. Effective treatment for this disease, however, has developed only over the last 60 years, and it is probably fair to say that we still do not understand the physiologic trigger for the process that leads to insulin-dependent (type I) diabetes nor the detailed mechanisms of beta-cell destruction. This lack of detailed knowledge is no reason to shy away from the subject. We are at a time when discussion and speculation is needed to focus our research approach. This is a stage of scientific development when new ideas and theories are hotly debated in the light of experimental data. In this chapter, we approach our subject as immunologists rather than endocrinologists; it is now clear that type I diabetes, both in man and in animal models, is a pathologic process with an immunologic etiology.1–3

Keywords

Islet Graft Kidney Capsule Islet Tissue Fetal Pancreas Islet Allograft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • Yi Wang
  • Liming Hao
  • Kevin J. Lafferty

There are no affiliations available

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