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Viral Pathogenesis of Insulin-Dependent Diabetes Mellitus

  • Ji-Won Yoon
Part of the Endocrinology and Metabolism book series (EAM, volume 4)

Abstract

The familial occurrence of diabetes, or at least, a tendency to develop the disease, has been long recognized, but the true nature of the genetic mechanisms governing transmission of the diabetes trait still is not well understood. Concordance for insulin-dependent diabetes mellitus (IDDM) between identical twins approaches 50%, suggesting that nongenetic influences, such as environmental factors, contribute to the clinical expression of a genetic susceptibility. Triggering factors that might induce diabetes include diabetogenic viruses, chemicals, diet, and toxins. Such likely candidates act either as primary injurious agents to pancreatic beta-cells or as triggers of autoimmunity in man and animals (Fig. 10.1).1,2

Keywords

Viral Antigen Rubella Virus Viral Pathogenesis Coxsackie Virus Encephalomyocarditis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • Ji-Won Yoon

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