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Autoimmunity and the Pathogenesis of Diabetes pp 1–28Cite as

The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present

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Part of the book series: Endocrinology and Metabolism ((EAM,volume 4))

Abstract

When considering hypotheses of autoimmunity in insulin-dependent diabetes mellitus (IDDM) the selection of 1965 as a starting point for discussion is not arbitrary. In his 1965 paper,1 Willy Gepts cautiously interpreted histopathologic findings in pancreases of recent-onset juvenile diabetic patients as supportive of the view pointing “to a possible immunologic derangement…of the greatest interest in view of the high frequency with which we have found inflammatory infiltrates in our recent-onset juvenile diabetics.” In other words Gepts not only stressed the common occurrence of inflammatory lesions in the islets of recent-onset young diabetics, but also linked the histopathologic findings with pathogenetic considerations. No doubt this early hypothesis inspired diabetologists to search for further evidence to support an immunologic basis for the development of IDDM, a search that has grown ever since, making diabetes immunology a rapidly expanding field. This volume is but one of several specialized issues that have been devoted to the etiopathogenesis of IDDM.

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  1. Thomas Mandrup-Poulsen
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  2. Jørn Nerup
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Editors and Affiliations

  1. Division of Pediatric Endocrinology and Metabolism, Mount Sinai School of Medicine, 10029-6574, New York, New York, USA

    Fredda Ginsberg-Fellner M.D. (Professor of Pediatrics, Director) (Professor of Pediatrics, Director)

  2. Mount Sinai School of Medicine, 10029-6574, New York, New York, USA

    Robert C. McEvoy M.D. (Professor of Pediatrics (Endocrinology) and Cell Biology) (Professor of Pediatrics (Endocrinology) and Cell Biology)

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© 1990 Springer-Verlag New York Inc.

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Mandrup-Poulsen, T., Nerup, J. (1990). The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present. In: Ginsberg-Fellner, F., McEvoy, R.C. (eds) Autoimmunity and the Pathogenesis of Diabetes. Endocrinology and Metabolism, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3218-6_1

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  • DOI: https://doi.org/10.1007/978-1-4612-3218-6_1

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