Granulocyte Colony-Stimulating Factor

  • S. Nagata
Part of the Springer Study Edition book series (SSE)


Granulocyte colony-stimulating factor (G-CSF) is one of the colony-stimulating factors (CSF) which stimulate colony formation from bone marrow cells. Of the four well-known CSFs, G-CSF is the one that specifically regulates proliferation, differentiation, survival, and activation of cells of the restricted neutrophilic granulocyte lineage (Metcalf 1985, 1986, 1987; Sachs 1987). Mouse G-CSF is also called MGI-1G (macrophage and granulocyte inducer type1, granulocyte) while human G-CSF has been designated pluripotent CSF (pluripoetin) or granulocyte-macrophage colony-stimulating factor ß (GM-CSFß). Recombinant DNA technology has been used to elucidate the molecular and genetic nature of G-CSF (Clark and Kamen 1987) and in vitro and in vivo functions of G-CSF have been extensively studied using recombinant G-CSF. Recent clinical application of G-CSF has shown that this hormone is valuable in the treatment of patients suffering from neutropenia. In this article, current information on G-CSF gene structure and function will be reviewed.


Neutrophilic Granulocyte Myeloid Leukemia Cell Myeloid Leukemia Cell Line Hemopoietic Growth Factor Splice Donor Sequence 
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