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Granulocyte Colony-Stimulating Factor

  • S. Nagata
Part of the Springer Study Edition book series (SSE)

Abstract

Granulocyte colony-stimulating factor (G-CSF) is one of the colony-stimulating factors (CSF) which stimulate colony formation from bone marrow cells. Of the four well-known CSFs, G-CSF is the one that specifically regulates proliferation, differentiation, survival, and activation of cells of the restricted neutrophilic granulocyte lineage (Metcalf 1985, 1986, 1987; Sachs 1987). Mouse G-CSF is also called MGI-1G (macrophage and granulocyte inducer type1, granulocyte) while human G-CSF has been designated pluripotent CSF (pluripoetin) or granulocyte-macrophage colony-stimulating factor ß (GM-CSFß). Recombinant DNA technology has been used to elucidate the molecular and genetic nature of G-CSF (Clark and Kamen 1987) and in vitro and in vivo functions of G-CSF have been extensively studied using recombinant G-CSF. Recent clinical application of G-CSF has shown that this hormone is valuable in the treatment of patients suffering from neutropenia. In this article, current information on G-CSF gene structure and function will be reviewed.

Keywords

Neutrophilic Granulocyte Myeloid Leukemia Cell Myeloid Leukemia Cell Line Hemopoietic Growth Factor Splice Donor Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • S. Nagata

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