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Interleukin-2

  • Chapter
Peptide Growth Factors and Their Receptors I

Part of the book series: Springer Study Edition ((SSE))

Abstract

Interleukin 2 (IL-2), one of the first lymphokines to be identified, plays a major role in the clonal expansion of T lymphocytes (T cells) by interacting with specific cell surface receptors (IL-2 receptors; Morgan et al. 1976; Smith 1984,1988; Taniguchi et al. 1986 a). Expression of both IL-2 and IL-2 receptor requires T cell activation, triggered primarily by the interaction of the antigen/MHC molecules: T cell receptor complex (CD3/Ti complex). Hence, in effect, clonal proliferation of antigen-specific T cells appears to occur via a process of signal transduction, wherein the specific interaction of antigen/MHC and the T cell receptor complex is converted into a pathway of cellular growth through the operation of the IL-2 system.

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Authors
  1. M. Hatakeyama
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  2. T. Taniguchi
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Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, 20892, Bethesda, MD, USA

    Michael B. Sporn M.D.  & Anita B. Roberts Ph.D.  & 

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Hatakeyama, M., Taniguchi, T. (1991). Interleukin-2. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Springer Study Edition. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3210-0_10

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  • DOI: https://doi.org/10.1007/978-1-4612-3210-0_10

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