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Relaxin Secretion by the Primate Corpus Luteum During Simulated Early Pregnancy in Hyperstimulated Menstrual Cycles

  • J. S. Ottobre
  • R. L. Stouffer
  • C. A. VandeVoort
  • A. C. Ottobre
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

Peripheral concentrations of immunoreactive relaxin are generally undetectable during the nonfertile menstrual cycle in humans (1, 2) and rhesus monkeys (3, 4), but become measurable during pregnancy (2, 3, 5–7). The major source of relaxin in primates is the corpus luteum (CL)(5, 8–10). Chorionic gonadotropin (CG) induces relaxin secretion in nonpregnant primates (4,11,12) and thus appears to be a primary stimulus for such induction during early pregnancy. Relaxin is thought to play a role in uterine quiescence during pregnancy (13) and may be an important component for successful pregnancy maintenance.

Keywords

Menstrual Cycle Rhesus Monkey Early Pregnancy Luteal Phase Corpus Luteum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    O’Byrne EM, Carriere BT, Sorensen L, Segaloff A, Schwabe C, Steinetz BG. Plasma immunoreactive relaxin levels in pregnant and nonpregnant women. J Clin Endocrinol Metab 1978; 47: 1106 – 10.PubMedCrossRefGoogle Scholar
  2. 2.
    Quagliarello J, Szlachter N, Steinetz BG, Goldsmith LT, Weiss G. Serial relaxin concentrations in human pregnancy. Am J Obstet Gynecol 1979; 135: 43 – 4.PubMedGoogle Scholar
  3. 3.
    Weiss G, Steinetz BG, Dierschke DJ, Fritz G. Relaxin secretion in the rhesus monkey. Biol Reprod 1981; 24: 565 – 7.PubMedCrossRefGoogle Scholar
  4. 4.
    Ottobre JS, Nixon WE, Stouffer RL. Induction of relaxin secretion in rhesus monkeys by human chorionic gonadotropin: Dependence on the age of the corpus luteum of the menstrual cycle. Biol Reprod 1984; 31: 1000 – 6.PubMedCrossRefGoogle Scholar
  5. 5.
    Weiss G, O’Byrne EM, Steinetz BG. Relaxin: A product of the human corpus luteum of pregnancy. Science 1976; 194: 948 – 9.PubMedCrossRefGoogle Scholar
  6. 6.
    O’Byrne EM, Steinetz BG. Radioimmunoassay (RIA) of relaxin in sera of various species using an antiserum to porcine relaxin (39377). Proc Soc Exp Biol Med 1976; 152: 272 – 6.PubMedGoogle Scholar
  7. 7.
    Quagliarello J, Steinetz BG, Weiss G. Relaxin secretion in early pregnancy. Obstet Gynecol 1979; 53: 62 – 3.PubMedGoogle Scholar
  8. 8.
    Mathieu P, Rahier J, Thomas K. Localization of relaxin in human gestational corpus luteum. Cell Tissue Res 1981; 219: 213 – 6.PubMedCrossRefGoogle Scholar
  9. 9.
    Nixon WE, Reid R, Abou-Hozaifa BM, Williams RF, Steinetz BG, Hodgen GD. Origin and regulation of relaxin secretion in monkeys: Effects of chorionic gonadotropin, luteectomy, fetectomy, and placentectomy. In: Greenwald GS, Terranova PF, eds. Factors regulating ovarian function. New York: Raven Press, 1983: 427 – 31.Google Scholar
  10. 10.
    Castracane VD, D’Eletto R, Weiss G. Relaxin secretion in the baboon (Papio cynecephalus). In: Greenwald GS, Terranova PF, eds. Factors regulating ovarian function. New York: Raven Press, 1983: 415 – 9.Google Scholar
  11. 11.
    Quagliarello J, Goldsmith L, Steinetz B, Lustig DS, Weiss G. Induction of relaxin secretion in nonpregnant women by human chorionic gonadotropin. J Clin Endocrinol Metab 1980; 51: 74 – 7.PubMedCrossRefGoogle Scholar
  12. 12.
    Nixon WE, Schenken RS, Reid R. Relaxin response to ovarian hyperstimulation during the menstrual cycle in monkeys [Abstract]. 65th Annual Meeting. Endocrine Society, 1983.Google Scholar
  13. 13.
    Sherwood OD. Relaxin. In: Knobil E, Neill JD, eds. The physiology of reproduction. New York: Raven Press, 1988: 585 – 673.Google Scholar
  14. 14.
    VandeVoort CA, Hess DL, Stouffer, RL. Luteal function following ovarian stimulation in rhesus monkeys for in vitro fertilization: Atypical response to human chorionic gonadotropin treatment simulating early pregnancy. Fertil Steril 1988; 49: 1071 – 5.PubMedGoogle Scholar
  15. 15.
    Olson JL, Rebar RW, Schreiber JR, Vaitukaitus JL. Shortened luteal phase after ovulation induction with human menopausal gonadotropin and human chorionic gonadotropin. Fertil Steril 1983; 39: 284 – 91.PubMedGoogle Scholar
  16. 16.
    Resko JA, Norman RL, Niswender GD, Spies HG. The relationship between progestins and gonadotropins during the late luteal phase of the menstrual cycle in rhesus monkeys. Endocrinology 1974; 94: 128 – 35.PubMedCrossRefGoogle Scholar
  17. 17.
    Resko JA, Ploem JG, Stadelman HL. Estrogens in fetal and maternal plasma of the rhesus monkey. Endocrinology 1975; 97: 425 – 30.PubMedCrossRefGoogle Scholar
  18. 18.
    Wolf DP, VandeVoort CA, Meyer-Haas GR, et al. In vitro fertilization and embryo transfer in the rhesus monkey. Biol Reprod 1989; 41: 335 – 46.PubMedCrossRefGoogle Scholar
  19. 19.
    Zeleznik AJ, Hutchison J. Luteotropic actions of LH on the macaque corpus luteum. In: Stouffer RL, ed. The primate ovary. New York: Plenum Press, 1987; 163 – 74.Google Scholar
  20. 20.
    Thomas K, Loumaye E, Ferin J. Relaxin in non-pregnant women during ovarian stimulation. Gynecol Obstet Invest 1980; 11: 75 – 80.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1991

Authors and Affiliations

  • J. S. Ottobre
  • R. L. Stouffer
  • C. A. VandeVoort
  • A. C. Ottobre

There are no affiliations available

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