Abstract
It is well known that a number of factors affect the proliferation, differentiation, and steroidogenesis of cultured rat granulosa cells. Two multifunctional protein kinases, such as cAMP-dependent protein kinase and protein kinase C, are thought to mediate intracellular signals in granulosa cells. Follicle stimulating hormone (FSH) induces granulosa cell differentiation and the steroidogenesis, which are mediated by the action of cAMP-dependent protein kinase (1–3). In contrast, phorbol ester inhibits FSH actions, such as cAMP formation, LH receptor expression, cholesterol side-chain cleavage enzyme synthesis, and progesterone production (4–7) via the activation of protein kinase C.
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© 1991 Springer-Verlag New York, Inc.
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Ohba, T., Ohta, Y., Miyazaki, K., Okamura, H., Miyamoto, E. (1991). Fetal Calf Serum: Eliciting Phosphorylation of Ca++/Calmodulin-Dependent Protein Kinase II in Cultured Rat Granulosa Cells. In: Gibori, G. (eds) Signaling Mechanisms and Gene Expression in the Ovary. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3200-1_20
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DOI: https://doi.org/10.1007/978-1-4612-3200-1_20
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