Intraovarian IGF-I System

  • Eli Y. Adashi
  • Carol E. Resnick
  • Eleuterio R. Hernandez
  • Arye Hurwitz
  • Charles T. Roberts
  • Derek Leroith
  • Ron Rosenfeld
Part of the Serono Symposia, USA book series (SERONOSYMP)


As the significance of putative intraovarian regulators becomes increasingly recognized, much of the attention centers on insulin-like growth factors (IGFs). Indeed, a large body of evidence now suggests the existence of an intraovarian IGF system complete with ligands, receptors, and binding proteins. More importantly, IGFs have been shown to exert a variety of significant effects at the level of the somatic ovarian cell, raising the possibility of a meaningful in vivo role. The above notwithstanding, there is at this time no compelling evidence to indicate that IGFs (or for that matter any other putative intraovarian regulator) are indispensable to ovarian function. However, a large body of a somewhat indirect nature strongly suggests such a possibility. It is the purpose of this communication to review and summarize key developments in this area.


Granulosa Cell Human Granulosa Cell Porcine Granulosa Cell Somatic Ovarian Cell Murine Granulosa Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York, Inc. 1991

Authors and Affiliations

  • Eli Y. Adashi
    • 1
  • Carol E. Resnick
    • 1
  • Eleuterio R. Hernandez
    • 1
  • Arye Hurwitz
    • 1
  • Charles T. Roberts
    • 2
  • Derek Leroith
    • 2
  • Ron Rosenfeld
    • 3
  1. 1.Division of Reproductive Endocrinology, Department of Obstetrics and GynecologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.NIHNIDDKBethesdaUSA
  3. 3.Pediatric EndocrinologyStanford University Medical CenterStanfordUSA

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