Colony-Stimulating Factor I in the Mouse and Human Uteroplacental Unit

  • Jeffrey W. Pollard
  • Serge Pampfer
  • Eric Daiter
  • David Barad
  • Robert J. Arceci
Part of the Serono Symposia, USA book series (SERONOSYMP)


The uterus has long been thought of as producing secretions (histotrophe) that support the development of the fetus (1). These secretions undoubtedly include polypeptide growth factors (2–3). Such growth factors may act to prepare the uterus for receipt of the blastocyst, to stimulate the proliferation and differentiation of the extraembryonic tissues, to influence the development of supporting structures, such as the maternal vasculature, or to act directly on the fetus. In addition, the placenta produces a variety of cytokines whose roles may be similar to those produced from the uterus (4). Interestingly, several of these uterine or placental growth factors were originally described to act on, or be produced by, hematopoietic cells (3). Thus, there may be an overlap between the growth factor regulation of embryonic development and hematopoiesis. In part, this overlap may be to regulate the maternal immunological response to the semi-allogenic fetus (5).


Uterine Epithelium Placental Cell Polypeptide Growth Factor Choriocarcinoma Cell Line Decidua Basalis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York, Inc. 1991

Authors and Affiliations

  • Jeffrey W. Pollard
    • 1
  • Serge Pampfer
    • 1
  • Eric Daiter
    • 2
  • David Barad
    • 2
  • Robert J. Arceci
    • 3
  1. 1.Department of Developmental Biology and CancerAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of Obstetrics and GynecologyAlbert Einstein College of MedicineBronxUSA
  3. 3.Department of Hematology/OncologyDana Farber Cancer Institute, The Children’s HospitalBostonUSA

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