Colony-Stimulating Factor I in the Mouse and Human Uteroplacental Unit
The uterus has long been thought of as producing secretions (histotrophe) that support the development of the fetus (1). These secretions undoubtedly include polypeptide growth factors (2–3). Such growth factors may act to prepare the uterus for receipt of the blastocyst, to stimulate the proliferation and differentiation of the extraembryonic tissues, to influence the development of supporting structures, such as the maternal vasculature, or to act directly on the fetus. In addition, the placenta produces a variety of cytokines whose roles may be similar to those produced from the uterus (4). Interestingly, several of these uterine or placental growth factors were originally described to act on, or be produced by, hematopoietic cells (3). Thus, there may be an overlap between the growth factor regulation of embryonic development and hematopoiesis. In part, this overlap may be to regulate the maternal immunological response to the semi-allogenic fetus (5).
KeywordsMigration Estrogen Tyrosine Adenocarcinoma Oncol
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