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Functional Consequences of Regional Heterogeneity in the Left Ventricle

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Theory of Heart

Part of the book series: Institute for Nonlinear Science ((INLS))

Abstract

The left ventricle is characterized by significant regional heterogeneity in structure, electrophysiology, and function. This discussion focuses on the functional consequences of regional heterogeneity. First we examine the extent of regional heterogeneity in deformations observed under physiologic conditions. The importance of considering the direction as well as the magnitude of maximal deformations will be emphasized. Second, we discuss potential mechanisms for regional heterogeneity in deformations. The potential contribution of electrophysiologic, anatomic, structural, and geometric factors will be considered. Third, we examine the functional consequences of regional heterogeneity using experimental models. Regional ischemia is used to examine the mechanical interaction between ischemic and nonischemic areas, that is, the interaction between “weak” and “strong” muscles. Regional inotropic stimulation is used to produce subtle alterations in regional heterogeneity to examine the mechanical interaction between “strong” and “stronger” muscles. Finally, we correlate some of the predictions from theoretical models of acute ischemia and chronic infarction with the experimental observations.

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Authors and Affiliations

  1. Cardiology Section, Department of Medicine, University of California, San Diego, USA

    Wilbur Y. W. Lew

  2. Veterans Administration Medical Center, San Diego, California, 92161, USA

    Wilbur Y. W. Lew

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Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    Leon Glass

  2. Department of Engineering Science, University of Auckland, Auckland, New Zealand

    Peter Hunter

  3. Department of Applied Mechanics and Engineering Science—Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA

    Andrew McCulloch

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Lew, W.Y.W. (1991). Functional Consequences of Regional Heterogeneity in the Left Ventricle. In: Glass, L., Hunter, P., McCulloch, A. (eds) Theory of Heart. Institute for Nonlinear Science. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3118-9_9

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  • DOI: https://doi.org/10.1007/978-1-4612-3118-9_9

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