Skip to main content

Abstract

Phencyclidine (PCP, angel dust, peace pill, cadillac, crystal joints, DOA) was synthesized in the 1960s by Parke–Davis Laboratories. The drug was originally intended for use as a surgical anesthetic, but it was found to produce violent postoperative psychosis (1,2). Because of its side effects, which included muscular rigidity as well as nightmares and frank delirium with frightening hallucinations and delusions, PCP was removed from the market for human use a few years after its introduction. It is still used as a tranquilizer in veterinary surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cohen S (1977). Angel dust. JAMA238:515–516.

    Article  PubMed  CAS  Google Scholar 

  2. Cohen S (1981). The Substance Abuse Problems. New York: Haworth.

    Google Scholar 

  3. Nicholi AM, Jr. (1984). Phencyclidine hydrochloride (PCP) use among college students: Subjective and clinical effects, toxicity, diagnosis and treatment. J Am Coll Health32:197–200.

    Article  PubMed  Google Scholar 

  4. Senay EC, Becker CE, Schnoll SH (1977). Emergency Treatment of the Drug–Abusing Patient: For Treatment Staff Physicians. Rosslyn, VA: National Drug Abuse Center.

    Google Scholar 

  5. Drug Enforcement Administration (1981). Drug Abuse Warning Network (DAWN) 1980 Annual Report, p. 130. Washington, DC: Drug Enforcement Administration.

    Google Scholar 

  6. Hinkely S, Greenwood J (1984). Emergency Room Visits in DAWN Projected to the Nation. Washington, DC: Drug Enforcement Administration.

    Google Scholar 

  7. Showalter CV, Thornton WE (1977). Clinical pharmacology of phencyclidine toxicity. Am J Psychiatry134:1234–1238.

    PubMed  CAS  Google Scholar 

  8. Allen RM, Young SJ (1978). Phencyclidine-induced psychosis. Am J Psychiatry135: 1081–1084.

    PubMed  CAS  Google Scholar 

  9. Fauman MA, Fauman BJ (1978). The psychiatric aspects of chronic phencyclidine (PCP) use: A study of phencyclidine users. In Phencyclidine (PCP) Abuse: An Appraisal, Petersen RC, Stillman, RC, eds., pp. 183–200. Rockville, MD: National Institute on Drug Abuse.

    Google Scholar 

  10. McAdams MT, ed. (1980). Phencyclidine Abuse Manual. Los Angeles: University of California Extension.

    Google Scholar 

  11. Kline NS, Lindenmayer JP (1981). Psychotropic Drugs: A Manual for Emergency Management of Overdosage, 2d Ed. Oradell, NJ: Medical Economics.

    Google Scholar 

  12. Done AK, Aronow R, Miceli JN (1978). The pharmacokinetics of phencyclidine in overdose and its treatment. In Phencyclidine (PCP) Abuse: An Appraisal, Petersen RC, Stillman RC, eds., pp. 210–217. Rockville, MD: National Institute on Drug Abuse.

    Google Scholar 

  13. Linder RL, Lerner SE, Burns RS (1981). PCP, the Devil’s Dust: Recognition, Management and Prevention of Phencyclidine Abuse. Belmont, CA: Wads worth.

    Google Scholar 

  14. Fauman MA, Fauman BJ (1979). Violence associated with phencyclidine abuse. Am J Psychiatry136:1584–1586.

    PubMed  CAS  Google Scholar 

  15. Smith DE, Wesson DR, Buston ME, et al. (1978). The diagnosis and treatment of the PCP abuse syndrome. In Phencyclidine (PCP) Abuse: An Appraisal, Petersen RC, Stillman, RC, eds., pp. 218–228. Rockville, MD: National Institute on Drug Abuse.

    Google Scholar 

  16. Schuckit MA, Morrissey ER (1978). Propoxyphene and phencyclidine (PCP) use in adolescents. J Clin Psychiatry39:7–13.

    PubMed  CAS  Google Scholar 

  17. DeAngelis GG, Goldstein E (1978). Long-term treatment of adolescent PCP abusers. In Phencyclidine (PCP) Abuse: An Appraisal, Petersen RC, Stillman, RC, eds., pp. 254–271. Rockville, MD: National Institute on Drug Abuse.

    Google Scholar 

  18. Miller NS, Gold MS (1987). The medical diagnosis and treatment of alcohol dependence. Med Times115 (9): 109–126.

    Google Scholar 

  19. Miller NS (1987). A primer of the treatment process for alcoholism and drug addiction. Psychiatry Lett5 (7): 30–37.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag New York

About this chapter

Cite this chapter

Miller, N.S. (1991). The Pharmacology of Phencyclidine. In: The Pharmacology of Alcohol and Drugs of Abuse and Addiction. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3044-1_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-3044-1_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7774-3

  • Online ISBN: 978-1-4612-3044-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics