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Use of Clomiphene Citrate for Ovulation Induction

  • Chapter
Ovulation Induction

Part of the book series: Clinical Perspectives in Obstetrics and Gynecology ((CPOG))

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Abstract

Clomiphene citrate (CC) is a nonsteroidal triphenylethylene compound currently used as the first choice of treatment for induction of ovulation in anovulatory or oligoovulatory women. It is suitable in cases in which endogenous gonadotropin secretion is desirable for induction of ovulation. Structurally, it is related to the potent synthetic estrogen diethylstilbestrol. At the recommended doses in humans, CC is an antiestrogen. Although the exact mechanism of action of an antiestrogen is not yet clear, CC binds to multiple target organs through the estrogen receptor machinery (i.e., it competes with estrogens for the receptor binding sites). The threshold of the antiestrogen effects of CC varies among tissue sites and depends on individual tissue estrogen receptor concentrations.

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Authors
  1. Josef Blankstein
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Editors and Affiliations

  1. Section of Reproductive Endocrinology and Infertility/A81, Department of Gynecology, The Cleveland Clinic Foundation, 44195-5037, Cleveland, Ohio, USA

    Robert L. Collins M.D. (Director of Education) (Director of Education)

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© 1991 Springer-Verlag New York, Inc.

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Blankstein, J. (1991). Use of Clomiphene Citrate for Ovulation Induction. In: Collins, R.L. (eds) Ovulation Induction. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3026-7_5

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  • DOI: https://doi.org/10.1007/978-1-4612-3026-7_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7766-8

  • Online ISBN: 978-1-4612-3026-7

  • eBook Packages: Springer Book Archive

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