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The Neuroendocrine Regulation of the Menstrual Cycle

  • Chapter
Ovulation Induction

Part of the book series: Clinical Perspectives in Obstetrics and Gynecology ((CPOG))

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Abstract

Neuroendocrinology is the study of the relationship between the nervous and endocrine systems, which together regulate the organism. The neuron typically transmits information along an axon, communicating with a target cell across a synapse. An endocrine cell secretes its chemical message, or hormone, into the circulation to affect a specific target organ. Both the neuron neurotransmitter and the endocrine hormone activate target cells through specific cell receptors. Furthermore, several kinds of peptides and neurotransmitters, synthesized by neurons, are also secreted by endocrine glands.

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References

  1. Reichlin S. Neuroendocrinology. In: Wilson JD, Foster DW, eds. Williams textbook of endocrinology. Seventh edition. Philadelphia: W. B. Saunders, 1985: 492–567.

    Google Scholar 

  2. Berglund RM, Page RB. Can the pituitary secrete directly to the brain? (affirmative anatomical evidence). Endocrinology. 1978; 102: 1325–38.

    Article  Google Scholar 

  3. Kletzky OA, Lobo RA. Reproductive neuroendocrinology. In: Mishell DR Jr, Davajan V, eds. Infertility, contraception and reproductive endocrinology. Second edition. Oradell, NJ: Medical Economics, 1986: 3–30.

    Google Scholar 

  4. Kase NG. Neuroendocrine control of gonadotropin secretion. In: Kase NG, Weingold AB, eds. Principles and practice of clinical gynecology. New York: John Wiley & Sons. 1983: 12536.

    Google Scholar 

  5. McCann SM. Luteinizing-hormone-releasing hormone. N Engl J Med. 1977; 296: 797–802.

    Article  PubMed  CAS  Google Scholar 

  6. Wang CF, Lasley BL, Lein A, et al. The functional changes of the pituitary gonadotropins during the menstrual cycle. J Clin Endocrinol Metab. 1976; 42: 718–28.

    Article  PubMed  CAS  Google Scholar 

  7. Hoff JD, Lasley BL, Wang CF, et al. The two pools of pituitary gonadotropin: regulation during the menstrual cycle. J Clin Endocrinol Metab. 1977; 44: 302–12.

    Article  PubMed  CAS  Google Scholar 

  8. Borges JLC, Scott D, Kaiser DL, et al. Ca’ dependence of gonadotropin releasing hormone stimulated luteinizing hormone secretion: in vitro studies, using continuous perfused dispersed rat antiserum pituitary cells. Endocrinology. 1983; 113: 557–62.

    Article  PubMed  CAS  Google Scholar 

  9. Wise PM, Rance N, Barr GD, et al. Further evidence that luteinizing hormone-releasing hormone also is follicle-stimulating hormone-releasing hormone. Endocrinology. 1979; 104: 940–47.

    Article  PubMed  CAS  Google Scholar 

  10. McCormack JT, Plant TM, Hess L, et al. The effect of luteinizing hormone releasing hormone (LHRH) antiserum administration on gonadotropin secretion in the rhesus monkey. Endocrinology. 1977; 100: 663–67.

    Article  PubMed  CAS  Google Scholar 

  11. Silverman AJ, Antunes JL, Ferin M, et al. The distribution of luteinizing hormone-releasing hormone (LHRH) in the hypothalamus of the rhesus monkey. Light microscopic studies using immunoperoxidase technique. Endocrinology. 1977; 101: 134–42.

    Article  PubMed  CAS  Google Scholar 

  12. Knobil E. The neuroendocrinology of the menstrual cycle. Recent Prog Horm Res. 1980; 36: 53–88.

    PubMed  CAS  Google Scholar 

  13. Speroff L, Glass RH, Kase NG. Clinical gynecologic endocrinology and infertility. Fourth edition. Baltimore: Williams & Wilkins. 1989: 51–90.

    Google Scholar 

  14. Atkinson LE, Bhattacharya AN, Monroe SE, et al. Effects of gonadectomy on plasma LH concentration in the rhesus monkey. Endocrinology. 1970; 87: 847–49.

    Article  PubMed  CAS  Google Scholar 

  15. Dierschke DJ, Bhattacharya AN, Atkinson LE, et al. Circhoral oscillations of plasma LH levels in the ovariectomized rhesus monkey. Endocrinology. 1970; 87: 850–53.

    Article  PubMed  CAS  Google Scholar 

  16. Norman RL, Lindstrom SA, Bangsberg D, et al. Pulsatile secretion of luteinizing hormone during the menstrual cycle of rhesus macaques. Endocrinology. 1984; 115: 261–66.

    Article  PubMed  CAS  Google Scholar 

  17. Yen SSC, Tsai CC, Naftolin F, et al. Pulsatile patterns of gonadotropin release in subjects with and without ovarian function. J Clin Endocrinol Metab. 1972; 34: 671–75.

    Article  PubMed  CAS  Google Scholar 

  18. Yen SSC, Tsai CC, Vandenberg G, et al. Gonadotropin dynamics in patients with gonadal dysgenesis: a model for the study of gonadotropin regulation. J Clin Endocrinol Metab. 1972; 35: 897–904.

    Article  PubMed  CAS  Google Scholar 

  19. Santen RJ, Bardin CW. Episodic luteinizing hormone secretion in man: pulse analysis, clinical interpretation, physiologic mechanisms. J Clin Invest. 1973; 52: 2617–28.

    Article  PubMed  CAS  Google Scholar 

  20. Reame N, Sauder SE, Kelch RP, et al. Pulsatile gonadotropin secretion during the human menstrual cycle: evidence for altered frequency of gonadotropin-releasing hormone secretion. J Clin Endocrinol Metab. 1984; 59: 328–37.

    Article  PubMed  CAS  Google Scholar 

  21. Filicori M, Santoro N, Merriam GR, et al. Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle. J Clin Endocrinol Me-tab. 1986; 62: 1136–44.

    Article  CAS  Google Scholar 

  22. Belchetz PE, Plant TM, Nakai Y, et al. Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin releasing hormone. Science. 1978; 202: 63132.

    Article  Google Scholar 

  23. Ferin M. Neuroendocrine control of ovarian function in the primate. J Reprod Fertil. 1983; 69: 369–81.

    Article  PubMed  CAS  Google Scholar 

  24. Carmel PN, Araki S, Ferin M. Pituitary stalk blood collection in rhesus monkeys: evidence for pulsatile release of gonadotropin releasing hormone (GnRH). Endocrinology. 1976; 99: 243–48.

    Article  PubMed  CAS  Google Scholar 

  25. Elkind-Hirsch K, Ravnikar V, Schiff I, et al. Determinations of endogenous immunoreactive luteinizing hormone-releasing hormone in human plasma. J Clin Endocrinol Metab. 1982; 54: 602–07.

    Article  PubMed  CAS  Google Scholar 

  26. Wilson RC, Kesner JS, Kaufman JM, et al. Central electrophysiologic correlates of pulsatile luteinizing hormone secretion in the rhesus monkey. Neuroendocrinology. 1984; 39: 25660.

    Google Scholar 

  27. Wildt L, Hausler A, Marshall G, et al. Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey. Endocrinology. 1981; 109: 376–85.

    Article  PubMed  CAS  Google Scholar 

  28. Marshall JC, Kelch RP. Gonadotropin-releasing hormone: role of pulsatile secretion in the regulation of reproduction. N Engl J Med. 1986; 315: 1459–68.

    Article  PubMed  CAS  Google Scholar 

  29. Neill JD, Patton JM, Dailey RA, et al. Luteinizing hormone releasing hormone (LHRH) in pituitary stalk blood of rhesus monkeys: Relationship to level of LH release. Endocrinology. 1977; 101: 430–34.

    Article  PubMed  CAS  Google Scholar 

  30. Filicori M, Butler JP, Crowley WF. Neuroendocrine regulation of the corpus luteum in the human evidence for pulsatile progesterone secretion. J Clin Invest. 1984; 73: 1638–47.

    Article  PubMed  CAS  Google Scholar 

  31. Pfaff DN, Gerlach JL, McEwen BS, et al. Auto-radiographic localization of hormone-concentrating cells in the brain of the female rhesus monkey. J Comp Neurol. 1976; 170: 279–94.

    Article  PubMed  CAS  Google Scholar 

  32. Nakai Y, Plant TM, Hess DL, et al. On the sites of the negative and positive feedback activity of estradiol in the control of gonadotropin secretion in the rhesus monkey. Endocrinology. 1978; 102: 1008–14.

    Article  PubMed  CAS  Google Scholar 

  33. Knobil E, Plant TM, Wildt L, et al. Control of the rhesus monkey menstrual cycle: Permissive role of hypothalamic gonadotropin-releasing hormone. Science. 1980; 207: 1371–73.

    PubMed  CAS  Google Scholar 

  34. Ferin M, Rosenblatt H, Carmel PW, et al. Estrogen-induced gonadotropin surges in female rhesus monkeys after pituitary stalk section. Endocrinology. 1979; 104: 50–52.

    Article  PubMed  CAS  Google Scholar 

  35. Crowley WF Jr, McArthur JW. Stimulation of the normal menstrual cycle in Kallmann’s syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH). J Clin Endocrinol Metab. 1980; 51: 173–75.

    Article  PubMed  Google Scholar 

  36. Levine JE, Norman RL, Gliessman PM, et al. In vivo gonadotropin-releasing hormone release and serum luteinizing hormone measurements in ovariectomized, estrogen-treated rhesus macaques. Endocrinology. 1985; 117: 711–21.

    Article  PubMed  CAS  Google Scholar 

  37. Ferin M, Carmel PN, Zimmerman EA, et al. Location of intrahypothalamic estrogen-responsive sites influencing LH secretion in the female rhesus monkey. Endocrinology. 1974; 95: 1059–68.

    Article  PubMed  CAS  Google Scholar 

  38. Chappel SC, Resko JA, Norman RL, et al. Studies in rhesus monkeys on the site where estrogen inhibits gonadotropin: delivery of 17-βestradiol to the hypothalamus and pituitary gland. J Clin Endocrinol Metab. 1981; 52: 1–8.

    Article  PubMed  CAS  Google Scholar 

  39. Keye WR Jr, Jaffe RB. Modulation of pituitary gonadotropin response to gonadotropin releasing hormone by estradiol. J Clin Endocrinol Metab. 1974; 38: 805–10.

    Article  PubMed  CAS  Google Scholar 

  40. Jaffe RB, Keye WR Jr. Estradiol augmentation of pituitary responsiveness to gonadotropinreleasing hormone in women. J Clin Endocrinol Metab. 1974; 39: 850–55.

    Article  PubMed  CAS  Google Scholar 

  41. Young JR, Jaffe RB. Strength duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing hormone in women II. Effects of varying concentrations of estradiol. J Clin Endocrinol Metab. 1976; 42: 432.

    Article  PubMed  CAS  Google Scholar 

  42. Adams TE, Norman RL, Spies HG. Gonadotropin-releasing hormone receptor binding and pituitary responsiveness in estradiol-primed monkeys. Science. 1981; 213: 1388–90.

    Article  PubMed  CAS  Google Scholar 

  43. Menon M, Peegel H, Katta V. Estradiol potentiation of gonadotropin-releasing hormone responsiveness in the anterior pituitary is mediated by an increase in gonadotropin-releasing hormone receptors. Am J Obstet Gynecol. 1985; 151: 534–40.

    PubMed  CAS  Google Scholar 

  44. Crowder ME, Nett TM. Pituitary content of gonadotropins and receptors for gonadotropinreleasing hormone (GnRH) and hypothalamic content of GnRH during the periovulatory period of the ewe. Endocrinology. 1984; 114: 234–39.

    Article  PubMed  CAS  Google Scholar 

  45. Veldhius JD, Evans WS, Rogal AD, et al. Pituitary self-priming action of gonadotropinreleasing hormone kinetics of estradiol’s potentiating effects on gonadotropin-releasing hormone-facilitated luteinizing hormone and follicle-stimulating hormone release in healthy postmenopausal women. J Clin Invest. 1986; 77: 1849–56.

    Article  Google Scholar 

  46. Ferland L, Marchetti B, Seguin C, et al. Associated changes of pituitary luteinizing hormone-releasing hormone (LHRH) receptors and responsiveness to the neurohormone induced by 17-β-estradiol and LHRH in vivo in the rat. Endocrinology. 1981; 109: 87–93.

    Article  PubMed  CAS  Google Scholar 

  47. Fritz MA, Speroff L: The endocrinology of the menstrual cycle: the interaction of folliculogenesis and neuroendocrine mechanisms. Fertil Steril. 1982; 38: 509–29.

    PubMed  CAS  Google Scholar 

  48. Dierschke DJ, Yamaji T, Karsch FJ, et al. Blockade by progesterone of estrogen-induced LH and FSH release in the rhesus monkey. Endocrinology. 1973; 92: 1496–1501.

    Article  PubMed  CAS  Google Scholar 

  49. Wildt L, Hutchinson JS, Marshall G, et al. On the site of action of progesterone in the blockade of the estradiol-induced gonadotropin dis charge in the rhesus monkey. Endocrinology. 1981; 109: 1293–94.

    Article  PubMed  CAS  Google Scholar 

  50. March CM, Goebelsmann V, Nakamura RM, et al. Roles of estradiol and progesterone in eliciting the midcycle luteinizing hormone and follicle-stimulating hormone surges. J Clin Endocrinol Metab. 1979; 49: 507–13.

    Article  PubMed  CAS  Google Scholar 

  51. Liu JH, Yen SSC. Induction of midcycle gonadotropin surge by ovarian steroids in women: a critical evaluation. J Clin Endocrinol Metab. 1983; 57: 797–802.

    Article  PubMed  CAS  Google Scholar 

  52. Lasley BL, Wang CF, Yen SSC. The effects of estrogen and progesterone on the functional capacity of the gonadotrophs. J Clin Endocri nol Metab. 1975; 41: 820–26.

    Article  CAS  Google Scholar 

  53. Collins RL, Hodgen GD. Blockade of the spontaneous midcycle gonadotropin surge in monkeys by RU 486: a progesterone antago nist or agonist? J Clin Endocrinol Metab. 1986; 63: 1270–76. 67.

    Google Scholar 

  54. Soules MR, Steiner RH, Clifton DK, et al. Pro gesterone modulation of pulsatile luteinizing hormone secretion in normal women. J Clin Endocrinol Metab. 1984; 58: 378–83.

    Article  PubMed  CAS  Google Scholar 

  55. Schnatz PT. Neuroendocrinology and the ovu-lation cycle-advances and review. Adv Psy chosom Med. 1985; 12: 4–24.

    CAS  Google Scholar 

  56. Bhattacharya AN, Dierschke DJ, Yamaji T, et al. The pharmacologic blockade of the circhoral mode of LH secretion in the ova riectomized rhesus monkey. Endocrinology. 1972; 90: 778–86.

    Article  PubMed  CAS  Google Scholar 

  57. Plant TM, Nakai Y, Belchetz P, et al. The sites of action of estradiol and phentolamine in the inhibition of the pulsatile, circhoral discharges of LH in the rhesus monkey (Macaca mulatto). Endocrinology. 1978; 102: 1015–18.

    Article  PubMed  CAS  Google Scholar 

  58. Kaufman JM, Kesner JS, Wilson RC, et al. Electrophysiological manifestation of luteiniz ing hormone-releasing hormone pulse gener ator activity in the rhesus monkey: influence of alpha-adrenergic and dopaminergic blocking agents. Endocrinology. 1985; 116: 1327–33.

    Article  PubMed  CAS  Google Scholar 

  59. Sarkar DK, Fink G. Gonadotropin-releasing hormone surge: possible modulation through post-synaptic adrenoreceptors and two pharmacologically distinct dopamine receptors. Endocrinology. 1981; 108: 862–67.

    Article  PubMed  CAS  Google Scholar 

  60. Judd HJ, Rakoff JS, Yen SSC Inhibition of gonadotropin and prolactin release by dopa-mine-effect of endogenous estradiol levels. J Clin Endocrinol Metab. 1978; 47: 494–98.

    Article  PubMed  CAS  Google Scholar 

  61. Andersen AN, Hagen C, Lange P, et al. Dopaminergic regulation of gonadotropin levels and pulsatility in normal women. Fertil Steril. 1987; 47: 391–97.

    PubMed  CAS  Google Scholar 

  62. Rasmusen DD, Liu JU, Wolf PL, et al. Gonadotropin-releasing hormone neurosecretion in the human hypothalamus: in vitro regulation by dopamine J Clin Endocrinol Metab. 1986; 62: 479–83.

    Article  Google Scholar 

  63. Futterweit W. Polycystic ovarian disease. New York: Springer-Verlag, 1984: 1–21.

    Google Scholar 

  64. Gindoff PR, Ferin M. Brain opioid peptides and menstrual cyclicity Semin Reprod Endocrinol. 1987; 5: 125–33.

    Google Scholar 

  65. Wardlaw SL, Wehrenberg WB, Ferin M, et al. High levels of β-endorphin in hypophysial portal blood. Endocrinol. 1980; 106: 1323–26.

    Article  CAS  Google Scholar 

  66. Wehrenberg WB, Wardlaw SL, Frantz AG, et al. β-endorphin in hypophyseal portal blood: variations throughout the menstrual cycle. Endocrinology. 1982; 111: 879–81.

    Article  PubMed  CAS  Google Scholar 

  67. Reid RL, Hoff JD, Yen SSC, et al. Effects of exogenous β-endorphin on pituitary hormonesecretion and its disappearance rate in normal human subjects. J Clin Endocrinol Metab. 1981; 52: 1179–83.

    Article  PubMed  CAS  Google Scholar 

  68. Quigley ME, Yen SSC. The role of endogenous opiates on LH secretion during the menstrual cycle. J Clin Endocrinol Metab. 1980; 51: 179–87.

    Article  PubMed  CAS  Google Scholar 

  69. Ropert AF, Quigley ME, Yen SSC. Endogenous opiates modulate pulsatile luteinizing hormone release in humans. J Clin Endocrinol Metab. 1981; 52: 583–85.

    Article  PubMed  CAS  Google Scholar 

  70. Snowden E, Khan-Dawood FS, Dawood MY. The effect of naloxone on endogenous opioid regulation of pituitary gonadotropins and prolactin during the menstrual cycle. J Clin Endocrinol Metab. 1984; 59: 298–302.

    Article  PubMed  CAS  Google Scholar 

  71. Shoupe D, Montz FJ, Lobo RA. The effects of estrogen and progesterone on endogenous opioid activity in oophorectomized women. J Clin Endocrinol Metab. 1985; 60: 178–83.

    Article  PubMed  CAS  Google Scholar 

  72. Wardlaw SL, Wehrenberg WB, Ferin M, et al. Effect of sex steroids on β-endorphin in hypophyseal portal blood. J Clin Endocrinol Metab. 1982; 55: 877–87.

    Article  PubMed  CAS  Google Scholar 

  73. Kesner JS, Kaufman JM, Wilson RC, et al. The effect of morphine on the electrophysiologic activity of the hypothalamic luteinizing hormone-releasing hormone pulse generator in the rhesus monkey. Neuroendocrinology. 1986; 43: 686–88.

    Article  PubMed  CAS  Google Scholar 

  74. Seifer DB, Collins RL. Current concepts of 13- endorphin physiology in female reproductive dysfunction. Fertil Steril. 1990 (in Press).

    Google Scholar 

  75. Amico JA, Seif SM, Robinson AG. Elevation of oxytocin and the oxytocin-associated neurophysin in the plasma of normal women during midcycle. J Clin Endocrinol Metab. 1981; 53: 1229–32.

    Article  PubMed  CAS  Google Scholar 

  76. Kaplan SA. The ovary and female sexual maturation. In: Rosenfield RL, ed. Clinical pediatric and adolescent endocrinology. Philadelphia: W. B. Saunders, 1982: 217–68.

    Google Scholar 

  77. Wildt L, Marshall G, Knobil E. Experimental induction of puberty in the infantile rhesus monkey. Science. 1980; 207: 1373–75.

    PubMed  CAS  Google Scholar 

  78. Marshall, JC, Kelch RP. Low dose pulsatile gonadotropin-releasing hormone in anorexia nervosa: a model of human pubertal development. J Clin Endocrinol Metab. 1979; 49: 7 1218.

    Google Scholar 

  79. Wilson ME, Gordon TP, Collins DC: Ontogeny of luteinizing hormone secretion and first ovulation in seasonal breeding rhesus monkeys. Endocrinology. 1986; 118: 293–301.

    Article  PubMed  CAS  Google Scholar 

  80. Frisch RE. Body fat, menarche and reproductive ability. Semin Reprod Endocrinol. 1985; 3: 45.

    Article  Google Scholar 

  81. Harris DA, Vanvleit G, Egli CA, et al. Somatomedin-C in normal puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. J Clin Endocrinol Metab. 1985; 61: 152–59.

    Article  PubMed  CAS  Google Scholar 

  82. Mansfield MJ, Rudlin CR, Crigler JF Jr, et al. Changes in growth and serum growth hormone and plasma somatomedin-C levels during suppression of gonadal sex steroid secretion in girls with central precocious puberty. J Clin Endocrinol Metab. 1988; 66: 3–9.

    Article  PubMed  CAS  Google Scholar 

  83. Boyar R, Finkelstein J, Roffwarg H, et al. Synchronization of augmented luteinizing hormone secretion with sleep during puberty. N Engl J Med. 1972; 287: 582–86.

    Article  PubMed  CAS  Google Scholar 

  84. Burstein S, Schaff-Blass E, Blass J, et al. The changing ratio of bioactive to immunoreactive luteinizing hormone (LH) through puberty principally reflects changing radioimmunoassay dose response characteristics. J Clin Endocrinol Metab. 1985; 61: 508–13.

    Article  PubMed  CAS  Google Scholar 

  85. Blankstein J, Mashrach S, Lunenfeld B. Regulation of the female reproductive system. In: Blankstein J, Mashrach S, Lunenfeld B, eds. Ovulation induction and in vitro fertilization. Chicago: Mosby-Year Book, 1986: 7–45.

    Google Scholar 

  86. Healy D, Hodgen G. The endocrinology of the human endometrium. Ob/Gyn Surv. 1983; 38: 509.

    CAS  Google Scholar 

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Authors
  1. Cynthia H. Meyers-Seifer
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  2. David B. Seifer
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Editors and Affiliations

  1. Section of Reproductive Endocrinology and Infertility/A81, Department of Gynecology, The Cleveland Clinic Foundation, 44195-5037, Cleveland, Ohio, USA

    Robert L. Collins M.D. (Director of Education) (Director of Education)

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Meyers-Seifer, C.H., Seifer, D.B. (1991). The Neuroendocrine Regulation of the Menstrual Cycle. In: Collins, R.L. (eds) Ovulation Induction. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3026-7_1

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  • DOI: https://doi.org/10.1007/978-1-4612-3026-7_1

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