Abstract
Although conventional vaccines have been demonstrated to be highly effective in stimulating protective immunity against a wide range of microorganisms, there are still instances in which suitable vaccines are lacking. For example, the inability to culture large quantities of numerous protozoal pathogens in vitro has prevented the development of conventional vaccines for these organisms. Other obstacles to the development of conventional vaccines include the poor humoral response of infants under the age of 2 years to certain polysaccharide antigens present on encapsulated bacteria (i.e., Neisseria meningitidis, Vibrio cholera, and Hemophilus influenzae) (1, 2). Also, the recent spread of the human immunodeficiency virus type 1 (HIV-1) and its possible origin and evolution from viruses isolated from nonhuman primate species has pointed up the necessity of developing a vaccine that is incapable of reverting to a virulent form. These obstacles have led to the development of a new generation of vaccines. Recombinant proteins, synthetic peptides, and anti-idiotypic antibodies represent relatively new technologies that are currently being examined for their potential use in stimulating immunity against various microorganisms (reviewed in 3 and 4). This report will review studies from this laboratory that examine the potential use of anti-Idiotype to generate immunity to HIV-1 and hepatitis B virus (HBV).
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References
Pincus DJ, Morrison D, Andrews C, Lawrence E, Sell SH, Wright PF: Age-related response to two Haemophilus influenzae type b vaccines. J Pediatr 1982; 100:197–201.
Parke JC Jr, Schneerson R, Robbins JB, Schlesselman JJ: Interim report of a controlled field trial immunization with capsular polysaccharides of Haemophilus influenzae type b and group C Neisseria meningitidis in Mecklenburg County, North Carolina (March 1974-March 1976). J Infect Dis 1977; (suppl) 136:s51–s56.
Arnon R: Peptides as immunogens: Prospects for synthetic vaccines. Curr Top Microbiol Immunol 1986; 130:1–12.
Hkrnaux JR: Idiotypic vaccines and infectious diseases. Infect Immun 1988; 56:1407–1413.
Jerne NK: Toward a network theory of the immune system. Ann Immunol (Paris) 1974; 125C:373–389.
Bona CA, Pernis B: Idiotypic networks. In: Paul WE, ed: Fundamental Immunology. New York: Raven Press; 1984; 577–592.
Bona CA ed: Biological Applications of Anti-Idiotypes, II. Boca Raton, Fla: CRC Press; 1988.
Jerne NK, Roland J, Cazenave P-A: Recurrent idiotopes and internal images. EMBO J 1982; l(2) :243–247.
Bona CA, Kohler H: Anti-idiotypic antibodies and internal images. In: Venter JC, Fräser CM, Linstrom J, eds: Monoclonal and Anti-Idiotypic Antibodies: Probes for Receptor Structure and Function. Receptor Biochemistry and Methodology Series, vol. 4. New York; Alan R. Liss; 1984: p 141–149.
Bruck C, Co MS, Slaoui M, et al: Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen. Proc Natl Acad Sci USA 1986; 83:6578–6582.
Bona CA, Finley S, Waters S, Kunkel HG: Anti-immunoglobulin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterologous anti-γ globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and epitopes and idiotopes (epibodies). J Exp Med 1982; 156:986–999.
Augustin A, Cosenza A: Expression of new idiotypeslollowing neonatal idiotypic suppression of a dominant clone. Eur J Immunol 1976; 6:497–501.
Bona C, Stein KE, Lieberman R, Paul WE: Direct and indirect suppression induced by anti-idiotype antibody in the insulin-bacterial levan antigenic system. Mol Immunol 1979; 16:1093–1101.
Sharpe AH, Gaulton GN, McDade KK, Fields BN, Greene MI: Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus. J Exp Med 1984; 160:1195–1205.
Nepom GT, Nelson KA, Holbeck SL, Hellström I, Hellström KE: Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice. Proc Natl Acad Sci USA 1984; 81:2864–2867.
Forstrom JW, Nelson KA, Nepom GT, Hellström I, Hellström KE: Immunization to a syngeneic sarcoma by a monoclonal auto-anti-idiotypic antibody. Nature 1983; 303:627–629.
Lee VK, Harriott TG, Kuchroo VK, Halliday WJ, Hellström I, Hellström KE: Monoclonal antiidiotypic antibodies related to a murine oncofetal bladder tumor antigen induce specific cell-mediated tumor immunity. Proc Natl Acad Sci USA 1985; 82:6286–6290.
Raychaudhuri S, Saeki Y, Chen JJ, Iribe H, Fuji H, Kohler H: Tumor-specific idiotype vaccines. II. Analysis of the tumor-related network response induced by the tumor and by internal image antigens (Ablß). J Immunol 1987; 139:271–278.
Gaulton GN, Sharpe AH, Chang DW, Fields BN, Greene MI: Syngeneic monoclonal internal image anti-idiotopes as prophylactic vaccines. J Immunol 1986; 137:2930–2936.
Zhou EM, Chanh TC, Dreesman GR, Kanda P, Kennedy RC: Immune response to human immunodeficiency virus. In vivo administration of antiidiotype induces an anti-gpl60 response specific for a synthetic peptide. J Immunol 1987; 139:2950–2956.
Dalgleish AG, Thomson BJ, Chanh TC, Malkovsky M, Kennedy RC: Neutralisation of HIV isolates by anti-idiotypic antibodies which mimic the T4 (CD4) epitope: A potential AIDS vaccine. Lancet 1987; 2:1047–1050.
Kennedy RC, Eichberg JW, Lanford RE, Dreesman GR: Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees. Science 1986; 232:220–223.
Kennedy RC, Melnick JL, Dreesman GR: Antibody to hepatitis B virus induced by injecting antibodies to the idiotype. Science 1984; 223:930–931.
Schick MR, Dreesman GR, Kennedy RC: Induction of an anti-hepatitis B surface antigen response in mice by noninternal image (Ab2α) anti-idiotypic antibodies. J Immunol 1987; 138:3419–3425.
Thanavala YM, Brown SE, Howard CR, Roitt IM, Steward MW: A surrogate hepatitis B virus antigenic epitope represented by a synthetic peptide and an internal image anti-idiotypic antibody. J Exp Med 1986; 164:227–236.
Colucci G, Beazer Y, Waksal S: Interactions between HBV and polymeric human serum albumin. II. Development of syngeneic monoclonal anti-anti-idiotypes which mimic hepatitis B surface antigen in the induction of immune responsiveness. Eur J Immunol 1987; 17:371–374.
Keay S, Rasmussen L, Merigan TC: Syngeneic monoclonal anti-idiotype antibodies that bear the internal image of a human cytomegalovirus neutralization epitope. J Immunol 1988; 140:944–948.
Ertl HCJ, Finberg RW: Sendai virus-specific T-cell clones: Induction of cytolytic T-eells by an anti-idiotypic antibody directed against a helper T-cell clone. Proc Natl Acad Sci USA 1984; 81:2850–2854.
Ertl HCJ, Homans E, Tournas S, Finberg RW: Sendai virus-specific T cell clones. V. Induction of a virus-specific response by antiidiotypic antibodies directed against a T helper cell clone. J Exp Med 1984; 159:1778–1783.
Reagan KJ, Wunner WH, Wiktor TJ, Koprowski H: Anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein. J Virol 1983; 48:660–666.
Uytdehaag FGCM, Osterhaus ADME: Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody. J Immunol 1985; 134:1225–1229.
Gell PGH, Moss PAH: Production of cell-mediated immune response to herpes simplex virus by immunization with anti-idiotypic heteroantisera. J Gen Virol 1985; 66:1801–1804.
Lathey JL, Courtney RJ, Rouse BT: Production, binding characteristics, and immunogenicity of heterologous anti-idiotypic antibody to herpes simplex virus glycoprotein C. Viral Immunol 1987; 1:13–24.
Mayer R, Ioannides C, Moran T, Johansson B, Bona C: Effect of syngeneic anti-idiotypic antibody on influenza virus neuraminidase antibody response. Viral Immunol 1987; 1:121–134.
Tanaka M, Sasaki N, Seto A: Induction of antibodies against Newcastle disease virus with syngeneic anti-idiotype antibodies in mice. Microbiol Immunol 1986; 30:323–331.
Paque RE, Miller R: Modulation of murine Coxsackievirus-induced myocarditis utilizing anti-idiotypes. Viral Immunol 1987; 1:207–224.
Ludwig DS, Finkelstein RA, Karu AE, Dallas WS, Ashby ER, Schoolnik GK: Anti-idiotypic antibodies as probes of protein active sites: Application to cholera tein subunit B. Proc Natl Acad Sci USA 1987; 84:3673–3677.
Chanh TC, Huot RI, Schick MR, Hewetson JF: Anti-idiotypic antibodies against a monoclonal antibody specific for the trichothecene mycotoxin T-2. Toxicol Appl Pharmacol 1989; 100:201–207.
Hiernaux J, Bona C, Baker PJ: Neonatal treatment with low doses of anti- idiotypic leads to the expression of a silent clone. J Exp Med 1981; 153:1004–1008.
Rubinstein LJ, Yeh M, Bona CA: Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells. J Exp Med 1982; 156:506–521.
Marvel J, Tassignon J, Brait M, et al: The influence of Vk gene polymorphism on the induction of silent idiotypes in the arsonate system. Mol Immunol 1987; 24:463–469.
Francotte M, Urbain J: Induction of anti-tobacco mosaic virus antibodies in mice by rabbit antiidiotypic antibodies. J Exp Med 1984; 160:1485–1494.
Bona CA, Heber-Katz E, Paul WE: Idiotype-anti-idiotype regulation. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones. J Exp Med 1981; 153:951–967.
Gottlieb MS, Schroff R, Schanker HM, et al: Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. Evidence of a new acquired cellular immunodeficiency. N Engl J Med 1981; 305:1425–1431.
Masur H, Michelis MA, Greene JB, et al: An outbreak of community-acquired Pneumocystis carinii penumonia. Initial manifestation of cellular immune dysfunction. N Engl J Med 1981; 305:1431–1438.
Siegal FP, Lopez C, Hammer GS, et al: Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med 1981; 305:1439–1444.
Wain-Hobson S, Sonigo P, Danos O, Cole S, Alizon M: Nucleotide sequence of the AIDS virus, LAV. Cell 1985; 40:9–17.
Ratner L, Haseltine W, Patarca R, et al: Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature 1985; 313:277–284.
Muesing MA, Smith DH, Cabradilla CD, Benton CV, Laskey LA, Capon DJ: Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus. Nature 1985; 313:450–458.
Sanchez-Pescador R, Power MD, Barr PJ, et al: Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Science 1985; 227:484–492.
Swain SL: T cell subsets and the recognition of MHC class. Immunol Rev 1983; 74:129–142.
Krensky AM, Reiss CS, Mier JW, Strominger JL, Burakoff SJ: Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+. Proc Natl Acad Sci USA 1982; 79:2365–2369.
Spits H, Borst J, Terhorst C, de Vries JE: The role of T cell differentiation markers in antigen-specific and lectin-dependent cellular cytotoxicity mediated by T8+ and T4+ human cytotoxic T cell clones directed at class I and class II MHC antigens. J Immunol 1982; 129:1563–1569.
Meuer SC, Schlossman SF, Reinherz EL: Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci USA 1982; 79:4395–4399.
Wilde DB, Marrack P, Kappler J, Dialynas DP, Fitch FW: Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4) blocks class II MHC antigen-specific proliferation release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J Immunol 1983; 131:2178–2183.
Swain SL, Dialynas DP, Fitch FW, English M: Monoclonal antibody to L3T4 blocks the function of T cells specific for class 2 major histocompatibility complex antigens. J Immunol 1984; 132:1118–1123.
Gay D, Maddon P, Sekaly R, et al: Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature 1987; 328:626–629.
Doyle C, Strominger JL: Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 1987; 330:256–259.
Reinherz EL, Schlossman SF: The differentiation and function of human T lymphocytes. Cell 1980; 19:821–827.
Dialynas DP, Quan ZS, Wall KA, et al: Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: Similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol 1983; 131:2445–2451.
Marrack P, Endres R, Shimonkevitz R, et al: The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product. J Exp Med 1983; 158:1077–1091.
Maddon PJ, Littman DR, Godfrey M, Maddon DE, Chess L, Axel R: The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: A new member of the immunoglobulin gene family. Cell 1985; 42:93–104.
Maddon PJ, Molineaux SM, Maddon DE, et al: Structure and expression of the human and mouse T4 genes. Proc Natl Acad Sci USA 1987; 84:9155–9159.
Clayton LK, Hussey RE, Steinbrich R, Ramachandran H, Husain Y, Reinherz EL: Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding. Nature 1988; 335:363–366.
Classon BJ, Tsagaratos J, McKenzie IFC, Walker ID: Partial primary structure of the T4 antigens of mouse and sheep: Assignment of intrachain disulfide bonds. Proc Natl Acad Sci USA 1986; 83:4499–4503.
Clark SJ, Jefferies WA, Barclay AN, Gagnon J, Williams AF: Peptide and nucleotide sequences of rat CD4 (w3/25) antigen: Evidence for derivation from a structure with four immunoglobulin-related domains. Proc Natl Acad Sci USA 1987; 84:1649–1653.
Littman DR, Gettner SN: Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene. Nature 1987; 325:453–455.
Benn S, Rutledge R, Folks T, et al: Genomic heterogeneity of AIDS retroviral isolates from North America and Zaire. Science 1985; 230:949–951.
Sonigo P, Alizon M, Staskus K, et al: Nucleotide sequence of the visna lentivirus. Relationship to the AIDS virus. Cell 1985; 42:369–382.
Myers G, Josephs SF, Berzofsky JA, Rabson AB, Smith TF, Wong-Staal F (eds): Human retroviruses and AIDS, 1989. A compilation and analysis of nucleic acid and amino acid sequences. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, 1989.
Wong-Staal F, Shaw GM, Hahn BH, et al: Genomic diversity of human T-lymphotropic virus type III (HTLV-III). Science 1985; 229:759–762.
Alizon M, Wain-Hobson S, Montagnier L, Sonigo P: Genetic variability of the AIDS virus: Nucleotide sequence analysis of two isolates from African patients. Cell 1986; 46:63–74.
Weiss RA, Clapham PR, Weber JN, Dalgleish AG, Laskey LA, Berman PW: Variable and conserved neutralization antigens of human immunodeficiency virus. Nature 1986; 324:572–575.
Saag MS, Hahn BH, Gibbons J, et al: Extensive variation of human immunodeficiency virus type-1 in vivo. Nature 1988; 334:440–444.
Fisher AG, Ensoli B, Looney D, et al: Biologically divergent molecular variants within a single HIV-1 isolate. Nature 1988; 334:444–447.
Fauci AS: The human immunodeficiency virus: Infectivity and mechanisms of pathogenesis. Science 1988; 239:617–622.
Halstead SB, O’Rourke EJ: Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. J Exp Med 1977; 146:201–217.
Robinson WE Jr, Montefiori DC, Mitchell WM: Antibody dependent enhancement of human immunodeficiency virus type 1 infection. Lancet 1988; 1:790–794.
Takeda A, Tuazon CU, Ennis FA: Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. Science 1988; 242:580–583.
Dalgleish AG: Human trials of AIDS vaccines: Novel means of passive and active immunotherapy. AIDS 2 1988; (suppl 1):S129–S131.
Snart RS: Human trials of experimental AIDS vaccines: Recombinant envelope proteins. AIDS 2 1988; (suppl 1):S107–111.
Kennedy RC, Chanh TC: Perspectives on developing anti-idiotype based vaccines for controlling HIV infection. AIDS 2 1988; (suppl 1):S119-S127.
Smith DH, Byrn RA, Marsters SA, Gregory T, Groopman JE, Capon DJ: Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen. Science 1987; 238:1704–1707.
Fisher RA, Bertonis JM, Meier W, et al: HIV infection is blocked in vitro by recombinant soluble CD4. Nature 1988; 331:76–78.
Hussey RE, Richardson NE, Kowalski M, et al: A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature 1988; 331:78–81.
Deen KC, McDougal JS, Inacker R, et al: A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature 1988; 331:82–84.
Traunecker A, Luke W, Karjalainen K: Soluble CD4 molecules neutralize human immunodeficiency virus type 1. Nature 1988; 331:84–86.
Sattentau QJ, Dalgleish AG, Weiss RA, Beverley PCL: Epitopes of the CD4 antigen and HIV infection. Science 1986; 234:1120–1123.
Chanh TC, Dreesman GR, Kennedy RC: Monoclonal anti-idiotypic antibody mimics the CD4 receptor and binds human immunodeficiency virus. Proc Natl Acad Sci USA 1987; 84:3891–3895.
Beasley RP: Hepatitis B virus as the etiologic agent in hepato-cellular carcinoma: Epidemiologic considerations. Hepatology 1982; 2:21–26.
McAuliffe VJ, Purcell RH, Gerin JL: Type B hepatitis: A review of current prospects for a safe and effective vaccine. Rev Infect Dis 1980; 2:470–492.
Levene C, Blumberg BS: Additional specificities of Australia antigen and the possible identification of hepatitis carriers. Nature 1969; 221:195–196.
Le Bouvier GL: The heterogeneity of Australia antigen. J Infect Dis 1971; 123:671–675.
Bancroft WH, Mundon FK, Russell PK: Detection of additional antigenic determinants of hepatitis B antigen. J Immunol 1972; 109:842–848.
Szmuness W, Stevens CE, Harley EJ, et al: Hepatitis B vaccine. Demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States. N Engl J Med 1980; 303:833–841.
Kennedy RC, Dreesman GR: Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen. J Immunol 1983; 130:385–389.
Kennedy RC, Sanchez Y, Ionescu-Matiu I, Melnick JL, Dreesman GR: A common human anti-hepatitis B surface antigen idiotype is associated with the group a conformation-dependent antigenic determinant. Virology 1982; 122:219.
Kennedy RC, Dreesman GR, Sparrow JT, et al: Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide. J Virol 1983; 46:653–655.
Kennedy RC, Ionescu-Matiu I, Sanchez Y, Dreesman GR: Detection of interspecies indiotypic cross-reactions associated with antibodies to hepatitis B surface antigen. Eur J Immuno 1983; 13:232–235.
Kennedy RC, Adler-Storthz K, Henkel RD, Sanchez Y, Melnick JL, Dreesman GR: Immune response to hepatitis B surface antigen: Enhancement by prior injection of antibodies to the idiotype. Science 1983; 221:853–855.
Kennedy RC, Sparrow JT, Sanchez Y, Melnick JL, Dreesman GR: Enhancement of viral hepatitis B antibody (anti-HBS) response to a synthetic cyclic peptide by priming with anti-idiotype antibodies. Virology 1984; 136:247–252.
Kennedy RC, Dreesman GR: Enhancement of the immune response to hepatitis B surface antigen. In vivo administration to antiidiotype induces anti-HB that expresses a similar idiotype. J Exp Med 1984; 159:655–665.
Kennedy RC, Eichberg JW, Dreesman GR: Lack of genetic restriction by i potential anti-idiotype vaccine type B viral hepatitis. Virology 1986; 148:369–374.
Rajewsky K, Takemori T: Genetics, expression, and function of idiotypes. Ann Rev Immunol 1983; 1:569–607.
Peltola H, Kayhty H, Sivonen A, Makela PH: Haemophilus influenzae type B capsular polysaccharide vaccine in children: A double-blind field study of 100,000 vaccines 3 months to 5 years of age in Finland. Pediatrics 1911; 60:730–737.
Peltola H, Kayhty H, Virtanen M, Makela PH: Prevention of Haemophilus influenzae type B bacteremic infections with the capsular polysaccharide vaccine. N Engl J Med 1984; 310:1561–1566.
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Warren, R.Q., Kennedy, R.C. (1991). Anti-Idiotypic Antibodies as Potential Viral Vaccines. In: Cazenave, PA. (eds) Anti-Idiotypic Vaccines. Progress in Vaccinology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2992-6_7
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