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Anti-Idiotypic Vaccines for Carbohydrate Antigens

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Anti-Idiotypic Vaccines

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 3))

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Abstract

In this chapter I will review the literature in which anti-idiotypic (anti-Id) antibodies have been used to induce or prime for an antibody response to a carbohydrate determinant, whether a polysaccharide or an oligosaccharide side chain of a glycoprotein or a synthetic conjugate. In each case the subject will be discussed in terms of the ability of anti-idiotypes to stimulate a response and in terms of the data presented that suggest that the anti-idiotype might behave as an internal image of antigen or Ab2β (1). The criteria I will use to determine whether an anti-idiotype is an internal image are those first discussed with reference to vaccines by Nisonoff and colleagues (2, 3).

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References

  1. Jerne NK, Roland J, Cazenave P-A: Recurrent idiotopes and internal images. EMBO J 1982; 1:243–247.

    PubMed  CAS  Google Scholar 

  2. Nisonoff A, Lamoyi E: Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine production. Clin Immunol Immunopathol 1981; 21:397–406.

    Article  PubMed  CAS  Google Scholar 

  3. Gurish MF, Nisonoff N: Potential use of anti-idiotype antibodies as vaccines, in Dreesman GR, Bronson JG, Kennedy RC, eds: Proc First Ann Southwest Foundation for Biomedical Research Int Symp Houston Texas Nov 8–10 1984. (American Society of Microbiology, Washington, D.C., 1985) p. 103.

    Google Scholar 

  4. Takemori T, Tesch H, Reth M, Rajewsky K: The immune response against anti-idiotope antibodies. I. Induction of idiotope-bearing antibodies and analysis of the idiotope repertoire. Eur J Immunol 1982; 12:1040–1046.

    Article  PubMed  CAS  Google Scholar 

  5. Epstein SL, Masakowski VR, Sharrow SO, Bluestone JA, Ozato K, Sachs DH: Idiotypes of anti-Ia antibodies. II. Effects of in vivo treatment with xenogeneic antiidiotype. J Immunol 1982; 129:1545–1552.

    PubMed  CAS  Google Scholar 

  6. Trenkner E, Riblet R: Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies. J Exp Med 1975; 142:1121–1132.

    Article  PubMed  CAS  Google Scholar 

  7. Sacks DL, Sher A: Evidence that anti-idiotype induced immunity to experimental African trypanosomiasis is genetically restricted and requires recognition of combining site-related idiotypes. J Immunol 1983; 131:1511.

    PubMed  CAS  Google Scholar 

  8. Lucas AH, Expression of crossreactive idiotypes by human antibodies specific for the capsular polysaccharide of Hemophilus influenzae B. J Clin Invest 1988; 81:480–486.

    Article  PubMed  CAS  Google Scholar 

  9. Lucas AH, Granoff DM: A major cross-reactive idiotype associated with human antibodies to the capsular polysaccharide of H. influenzae B; expression in relation to age and vaccine. FASEB J 1989; 3:A1270–A1270. Abstract.

    Google Scholar 

  10. Rosen SM, Allen C, Waksal HW: Presence of internal image on murine monoclonal anti-idiotypes to human antibody directed against polyribosyl-ribitol phosphate (PRP) of Haemophilus influenzae type B. FASEB J 1989; 3:A674–A674. Abstract.

    Google Scholar 

  11. Altevogt P, Wigzell H: A VH-Associated idiotype in human anti-tetanus antibodies. Scand J Immunol 1983; 17:183–192.

    Article  PubMed  CAS  Google Scholar 

  12. Hoffman WL, Strucely PD, Jump A A, Smiley JD: A restricted human antitetanus clonotype shares idiotypic cross-reactivity with tetanus antibodies from most human donors and rabbits: Reactivity with antibodies of widely differing electrophoretic mobility. J Immunol 1985; 135:3802–3807.

    PubMed  CAS  Google Scholar 

  13. Emmrich F, Zenke G, Eichmann K: Isotype restriction of idiotopes associated with human anti-streptococcal A carbohydrate antibodies. Eur J Immunol 1986; 16:542–546.

    Article  PubMed  CAS  Google Scholar 

  14. de Saint Basile G, Durandy A, Somme G, Griscelli C: Idiotypy of human anti- Candida albicans antibodies: Recurrence, presence of a cross-reactive autoanti-idiotypic-like activity, and role in the induction of specific in vitro antibody response. J Immunol 1987; 138:417–422.

    PubMed  Google Scholar 

  15. Kayhty H, Karanko V, Peltola H, Makela PH: Serum antibodies after vaccination with Haemophilus influenzae type B capsular polysaccharide and responses to reimmunization: No evidence of immunologic tolerance or memory. Pediatrics 1984; 74:857–865.

    PubMed  CAS  Google Scholar 

  16. Parke JC Jr, Schneerson R, Robbins JB, Schlesselman JJ: Interim report of a controlled field trial of immunization with capsular polysaccharides of Haemophilus influenzae type b and group C Neisseria meningitidis in Mecklenburg County, North Carolina (March 1974-March 1976). J Infect Dis 1977; 136S:S51–S56.

    Google Scholar 

  17. Peltola H, Kayhty H, Sivonen A, Makela PH: Haemophilus influenzae type capsular polysaccharide vaccine in children: A double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland. Pediatrics 1977; 60:730–737.

    PubMed  CAS  Google Scholar 

  18. Smith DH, Peter G, Ingram DL, Harding AL, Anderson P: Responses of children immunized with the capsular polysaccharide of Hemophilus influenzae, type b. Pediatrics 1973; 52:637–644.

    PubMed  CAS  Google Scholar 

  19. Bona C, Mond JJ, Stein KE, House S, Lieberman R, Paul WE: Immune response to levan. III. The capacity to produce anti-inulin antibodies and cross-reactive idiotypes appears late in ontogeny. J Immunol 1979; 123:1484–1490.

    PubMed  CAS  Google Scholar 

  20. Stein KE, Zopf DA, Miller CB, et al: The immune response to a thymus-dependent form of B512 Dextran requires the presence of Lyb5+ lymphocytes. J Exp Med 1983; 157:657–666.

    Article  PubMed  CAS  Google Scholar 

  21. Schneerson R, Robbins JB, Chu C, et al: Serum antibody responses of juvenile and infant rhesus monkeys injected with Haemophilus influenzae type B and pneumococcus type 6A capsular polysaccharide-protein conjugates. Infect Immun 1984; 45:582–591.

    PubMed  CAS  Google Scholar 

  22. Eskola J, Kayhty H, Peltola H, et al: Antibody levels achieved in infants by course of Haemophilus influenzae type b polysaccharide/diphtheria toxoid conjugate vaccine. Lancet 1985; 1:1184–1186.

    Article  PubMed  CAS  Google Scholar 

  23. Anderson P, Pichichero ME, Insel RA: Immunization of 2-month-old infants with protein-coupled oligosaccharides derived from the capsule of Haemophilus influenzae type b. J Pediatr 1985; 107:346–351.

    Article  PubMed  CAS  Google Scholar 

  24. Lepow ML, Samuelson JS, Gordon LK: Safety and immunogenicity of Haemophilus influenzae type b-polysaccharide diphtheria toxoid conjugate vaccine in infants 9 to 15 months of age. J Pediatr 1985; 106:185–189.

    Article  PubMed  CAS  Google Scholar 

  25. Insel RA, Anderson PW: Oligosaccharide-protein conjugate vaccines induce and prime for oligoclonal IgG antibody responses to the Haemophilus influenzae b capsular polysaccharide in human infants. J Exp Med 1986; 163:262–269.

    Article  PubMed  CAS  Google Scholar 

  26. Miller GG, Nadler PI, Asano Y, Hodes RJ, Sachs DH: Induction of idiotype-bearing nuclease-specific helper T cells by in vivo treatment with anti-idiotype. J Exp Med 1981; 154:24–34.

    Article  PubMed  CAS  Google Scholar 

  27. Westerink MAJ, Campagnari AA, Wirth MA, Apicella MA: Development and characterization of an anti-idiotype antibody to the capsular polysaccharide of Neisseria meningitidis serogroup C. Infect Immun 1988; 56:1120–1127.

    PubMed  CAS  Google Scholar 

  28. Insel RA, Anderson PW: Response to oligosaccharide—protein conjugate vaccine against Hemophilus influenzae b in two patients with IgG2 deficiency unresponsive to capsular polysaccharide vaccine. N Engl J Med 1986; 315:499–503.

    Article  PubMed  CAS  Google Scholar 

  29. Lieberman R, Potter M, Humphrey W Jr, Mushinski EB, Vrana M: Multiple individual and cross-specific idiotypes on 13 levan-binding myeloma proteins of BALB/c mice. J Exp Med 1975; 142:106–119.

    Article  PubMed  CAS  Google Scholar 

  30. Hiernaux J, Bona C, Baker PJ: Neonatal treatment with low doses of anti-idiotype antibody leads to the expression of a silent clone. J Exp Med 1981; 153:1004–1008.

    Article  PubMed  CAS  Google Scholar 

  31. Rubinstein LJ, Goldberg B, Hiernaux J, Stein KE, Bona CA: Idiotype-antiidiotype Regulation V. The requirement for immunization with antigen or monoclonal antiidiotype antibodies for the activation of beta (2–6) and beta (2–1) polyfructosan- reactive clones in BALB/c mice treated at birth with minute amounts of anti-A48 idiotype antibodies. J Exp Med 1983; 158:1129–1144.

    Article  PubMed  CAS  Google Scholar 

  32. Bluestone JA, Auchincloss H Jr, Epstein SL, Sachs DH: Idiotypes of anti-MHC monoclonal antibodies. In: Kohler H, Urbain J, Cazenave P-A eds: Idiotypy in Biology and Medicine. Orlando, Fla: Academic Press; 1984: p 243.

    Google Scholar 

  33. Stein KE, Söderström T: Neonatal administration of idiotype or antiidiotype primes for protection against E. coli Kl3 infection in mice. J Exp Med 1984; 160:1001–1011.

    Article  PubMed  CAS  Google Scholar 

  34. Vann WF, Söderström T, Egan W, et al: Serological, chemical, and structural analyses of the Escherichia coli cross-reactive capsular polysaccharides K13, K20, and K23, Infect Immun 1983; 39:623–629.

    PubMed  CAS  Google Scholar 

  35. Söderström, T, Stein K, Brinton CC Jr, et al: Analysis of Escherichia coli Kl, K13 and Type 1 pilus antigens with monoclonal antibodies. In: Hanson LÅ, ed: Progress in Allergy Vol. 33. Basel: Karger; 1983:259.

    Google Scholar 

  36. Söderström T, Brinton CC Jr, Fusco P, et al: Analysis of pilus mediated pathogenic mechanisms with monoclonal antibodies. In: Schlessinger D ed: Microbiology 1982 Washington, D.C., ASM Publications; 1982: p 305.

    Google Scholar 

  37. Kelsoe G, Reth M, Rajewsky K: Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody. Eur J Immunol 1981; 11:418–423.

    Article  PubMed  CAS  Google Scholar 

  38. Snary D, Ferguson MAJ, Scott MT, Allen AK: Cell surface antigens of Trypanosoma cruzi: Use of monoclonal antibodies to identify and isolate a epimastigote specific glycoprotein. Mol Biochem Parasit 1981; 3:343.

    Article  CAS  Google Scholar 

  39. Ferguson MAJ, Allen AK, Snary D: Studies on the structure of phosphogly-coprotein from the parasitic protozoan Trapanosoma cruzi. J Biochem 1983; 213:313.

    CAS  Google Scholar 

  40. Sacks DL, Kirchhoff LV, Hieny S, Sher A: Molecular mimicry of a carbohydrate epitope on a major surface glycoprotein of Trypanosoma cruzi by using anti-idiotypic antibodies. J Immunol 1985; 135:4155–4159.

    PubMed  CAS  Google Scholar 

  41. Coligan JE, Schnute WC Jr, Kindt TJ: Immunochemical and chemical studies on streptococcal group-specific carbohydrates. J Immunol 1975; 114:1654–1658.

    PubMed  CAS  Google Scholar 

  42. Briles DE, Davie JM: Clonal dominance I. Restricted nature of the IgM antibody response to group A streptococcal carbohydrate in mice. J Exp Med 1975; 141:1291–1307.

    Article  PubMed  CAS  Google Scholar 

  43. Bloem A, Zenke G, Eichmann K, Emmrich F: Human immune response to group A streptococcal carbohydrate (A-CHO). II. Antigen-independent stimulation of IgM Anti-A-CHO production in purified B cells by a monoclonal anti-idiotypic antibody. J Immunol 1988; 140:277–282.

    PubMed  CAS  Google Scholar 

  44. Rubinstein LJ, Stein KE: Murine immune response to the Neisseria meningitidis group C capsular polysaccharide. I. Ontogeny. J Immunol 1988; 141:4352–4356.

    PubMed  CAS  Google Scholar 

  45. Diakun KR, Matta KL: Synthetic antigens as immunogens: Part III. Specificity of an anti-anti-idiotypic antibody to a carbohydrate tumor-associated antigen. J Immunol 1989; 142:2037–2040.

    PubMed  CAS  Google Scholar 

  46. Misplon JA, Kindt RH, Reeves JP, Harvath L, Rubinstein LJ, Epstein SL:.Induction of antigen-specific immunity by anti-idiotypic antibodies: Isotype expression in responses and potency of induction by monoclonal anti-idiotypes. In: Osterhaus, AD ME, Urbain J, Uytdehaag FGCM, eds: Proceedings, Idiotype Networks in Biology and Medicine Congress, Gennep. The Netherlands. 17–20 April 1989. Amsterdam: Elsevier Science Publishers; 1990:51.

    Google Scholar 

  47. Bruck C, Co MS, Slaoui M, et al: Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen. Proc Natl Acad Sci USA 1986; 83:6578–6582.

    Article  PubMed  CAS  Google Scholar 

  48. Williams WV, London SD, Weiner DB, et al: Immune response to a molecularly defined internal image idiotype. J Immunol 1989; 142:4392–4400.

    PubMed  CAS  Google Scholar 

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Authors
  1. Kathryn E. Stein
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  1. 28, Rue du Dr. Roux, F-75724, Paris Cedex 15, France

    P.-A. Cazenave

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© 1991 Springer-Verlag New York Inc.

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Stein, K.E. (1991). Anti-Idiotypic Vaccines for Carbohydrate Antigens. In: Cazenave, PA. (eds) Anti-Idiotypic Vaccines. Progress in Vaccinology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2992-6_4

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  • DOI: https://doi.org/10.1007/978-1-4612-2992-6_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7750-7

  • Online ISBN: 978-1-4612-2992-6

  • eBook Packages: Springer Book Archive

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