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Cell Surface Receptors Required for Herpes simplex Virus Infection Include Heparan Sulfate Glycosaminoglycans

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Microbial Adhesion and Invasion

Abstract

Herpes simplex virus (HSV) is one of the several biologically distinct herpes viruses that cause disease in humans. The most common manifestations of HSV disease include keratitis and cutaneous lesions, such as cold sores and fever blisters, and similar lesions on genital organs. Rarely, the virus can induce more serious disease such as encephalitis and disseminated infections affecting several organ systems. HSV is not eliminated following the healing of lesions but persists as latent virus in the neurons of sensory or autonomic ganglia connecting with sites of viral inoculation or replication. Reactivation of latent virus is responsible for the recurrences of lesions that afflict many people. There are two serotypes of HSV, designated HSV-1 and HSV-2. HSV-1 is most commonly associated with facial lesions, keratitis and encephalitis in adults whereas HSV-2 is most commonly associated with genital lesions and neonatal infections (Corey et al, 1988).

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Authors
  1. Patricia G. Spear
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  2. Mei-Tsu Shieh
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  3. Betsy C. Herold
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  4. Darrell WuDunn
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, University of Alabama, 35294, Birmingham, AL, USA

    Magnus Hook Ph.D.

  2. Departments of Microbiology and Biochemistry, and Periodontics, School of Dental Medicine University of Pittsburgh, 15261, Pittsburgh, PA, USA

    Lech Switalski Ph.D.

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© 1992 Springer-Verlag New York, Inc.

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Spear, P.G., Shieh, MT., Herold, B.C., WuDunn, D. (1992). Cell Surface Receptors Required for Herpes simplex Virus Infection Include Heparan Sulfate Glycosaminoglycans. In: Hook, M., Switalski, L. (eds) Microbial Adhesion and Invasion. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2924-7_4

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  • DOI: https://doi.org/10.1007/978-1-4612-2924-7_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7721-7

  • Online ISBN: 978-1-4612-2924-7

  • eBook Packages: Springer Book Archive

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