Molecular Interactions between Human Rhinoviruses and the Adhesion Receptor ICAM-1
Human rhinoviruses (HRVs), members of the Picornaviridae, are the major causative agents of one of the more elusive diseases known to man, namely the common cold (Gwaltney, 1982). To date, there are 102 recognized serotypes that have been isolated and shown to be antigenically distinct (Hamparian et al., 1987). HRVs are non-enveloped viruses that contain four non-glycosylated structural proteins, designated VP1, VP2, VP3, and VP4, which form a protein capsid with icosahedral symmetry. Within the viral capsid lies a single-stranded genome RNA which serves as a monocistronic mRNA for the synthesis of the 4 structural and 7 nonstructural proteins of the virus. Upon entry into a cell, the RNA genome is translated into a large polyprotein which is subsequently cleaved by two viral proteases encoded within the polyprotein (Palmenberg, 1987). The genome RNA of picornaviruses contains all the information needed to initiate a viral infection since transfection of cells with the genome RNA alone will result in the production of infectious progeny virus (Mizutani et al., 1985).
KeywordsHydroxyl Carbohydrate Glutathione Polypeptide Polyacrylamide
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