Gonadotropin Releasing Hormone Antagonist Plus Testosterone: A Potential Male Contraceptive

  • William J. Bremner
  • Carrie J. Bagatell
  • Robert A. Steiner
Conference paper
Part of the Serono Symposia, USA book series (SERONOSYMP)


Although hormonal regimens provide effective, reversible contraception for women, no effective hormonal contraceptive regimen has yet been developed for men. Testosterone decreases gonadotropin secretion by exerting negative feedback at both the hypothalamus and pituitary (1–3), thereby inhibiting spermatogenesis. Administration of exogenous T causes azoospermia in only 50–70% of men, however (4). Agonist analogs of GnRH can inhibit gonadotropin secretion and gonadal function (5), but they do not consistently induce azoospermia in primates when given alone or in combination with androgen (6–9).


Sperm Count GnRH Antagonist Endocrine Society Testosterone Enanthate Androgen Replacement 
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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • William J. Bremner
  • Carrie J. Bagatell
  • Robert A. Steiner

There are no affiliations available

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