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Critical Determinants of GnRH-Gonadotrope Interactions in the Human

  • Conference paper
Modes of Action of GnRH and GnRH Analogs

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

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Abstract

The study of GnRH physiology in the human has proven to be complex, with both technical and practical obstacles. Specifically, the rapid metabolism of GnRH continues to make its direct measurement in the peripheral circulation limited in utility in defining the neuroendocrine control of reproduction in the human (1, 2). The inaccessibility of the hypophyseal-portal blood supply to direct sampling also means that a series of indirect approaches must be undertaken, using several strategies to piece together a complete story of the hypothalamic control of gonadotropin function. Thus, we have chosen to use complementary approaches involving the tandem study of GnRH-deficient men as well as of normal men with intact hypothalamic pituitary axes (3).

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Authors
  1. Randall W. Whitcomb
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  2. William F. Crowley Jr.
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Editor information

Editors and Affiliations

  1. Reproductive Endocrine Unit Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA

    William F. Crowley Jr. M.D.

  2. Department of Pharmacology, University of Iowa College of Medicine, Iowa City, IA, 52242-1109, USA

    P. Michael Conn Ph.D.

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© 1992 Springer-Verlag New York, Inc.

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Whitcomb, R.W., Crowley, W.F. (1992). Critical Determinants of GnRH-Gonadotrope Interactions in the Human. In: Crowley, W.F., Conn, P.M. (eds) Modes of Action of GnRH and GnRH Analogs. Serono Symposia, USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2916-2_1

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  • DOI: https://doi.org/10.1007/978-1-4612-2916-2_1

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7718-7

  • Online ISBN: 978-1-4612-2916-2

  • eBook Packages: Springer Book Archive

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