Skip to main content
SpringerLink
Log in
Book cover

Epidermolysis Bullosa pp 267–280Cite as

Medical and Surgical Treatment of the Skin in Epidermolysis Bullosa

  • Chapter

Abstract

Although no cure exists for any form of EB, many agents have been tried in the hope of uncovering therapeutic success. In this chapter we review treatments aimed specifically at decreasing cutaneous blistering. General principles of wound care as applied to the EB patient and treatments designed to improve extracutaneous complications are reviewed elsewhere in this text.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Carter DM, Caldwell D, Varghese M, Balin AK. Effectiveness of Bactroban ointment in chronic skin infection: report of a clinical study. In: Dobson RL, Leyden JJ, Noble WC, Price JD, eds. Bactroban (Mupirocin): Proceedings of an International Symposium. Amsterdam: Excerpta Medica; 1985: 228–234.

    Google Scholar 

  2. Caldwell D, Carter DM, Lin A, Varghese M. Topical mupirocin in epidermolysis bullosa: safety and efficacy of long-term treatment. In: Wood C, eds. Proceedings of the Royal Society of Medicine; Round Table Series, Number 4. Oxford: Alden Press; 1986:12–26.

    Google Scholar 

  3. Lin AN, Caldwell D, Varghese M, Pratt L, Balin A, Carter DM. Efficacy of long term mupirocin therapy in epidermolysis bullosa and its effect on growth and lifespan on cultured fibroblasts. J Invest Dermatol. 1986; 87:152.

    Google Scholar 

  4. Rahman M, Noble WC, Cookson B. Mupirocin-resistant Staphylococcus aureus (letter). Lancet. 1987;2:387.

    Google Scholar 

  5. Moy J, Caldwell-Brown D, Lin AN, Pappa KA, Carter DM. Mupirocin-resistant Staphylococcus aureus after long-term treatment of patients with epidermolysis bullosa. J Am Acad Dermatol. 1990;22:893–895.

    PubMed  CAS  Google Scholar 

  6. Bauer EA, Eisen AZ. Recessive dystrophic epidermolysis bullosa: evidence for increased collagenase as a genetic characteristic in cell culture. J Exp Med. 1978;148:1378–1387.

    PubMed  CAS  Google Scholar 

  7. Eisenberg M, Stevens LJ, Schofield PJ. Epidermolysis bullosa: new therapeutic approaches. Austr J Dermatol. 1978; 19:1–8.

    CAS  Google Scholar 

  8. Bauer EA, Tabas M. A perspective on the role of collagenase in recessive dystrophic epidermolysis bullosa. Arch Dermatol. 1988; 124:734–736.

    PubMed  CAS  Google Scholar 

  9. Bauer EA, Cooper TW, Tucker DR, Esterly NB. Phenytoin therapy of recessive dystrophic epidermolysis bullosa: clinical trial and proposed mechanism of action on collagenase. N Engl J Med. 1980; 303:776–781.

    PubMed  CAS  Google Scholar 

  10. Cooper TW, Bauer EA. Therapeutic efficacy of phenytoin in recessive dystrophic epidermolysis bullosa. Arch Dermatol. 1984; 120:490–495.

    PubMed  CAS  Google Scholar 

  11. Lin AN., Stern RB, Caldwell-Brown D, Carter DM, collaborators. Phenytoin for recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 1989; 92:472.

    Google Scholar 

  12. Winberg J-O, Real C, Gedde-Dahl Jr T, Bauer EA. Collagenase expression in skin fibroblasts from families with recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 1989; 92:82–85.

    PubMed  CAS  Google Scholar 

  13. Kero M. Epidermolysis bullosa in Finland: clinical features, morphology and relation to collagen metabolism. Acta Derm Venereol (Stockh). 1984; Suppl 110:1–51.

    CAS  Google Scholar 

  14. Kero M, Palotie A, Peltonen L. Collagen metabolism in two rare forms of epidermolysis bullosa. Br J Dermatol. 1984; 110:177–184.

    PubMed  CAS  Google Scholar 

  15. Fine J-D, Johnson L. Efficacy of systemic phenytoin in the treatment of junctional epidermolysis bullosa. Arch Dermatol. 1988; 124:1402–1406.

    PubMed  CAS  Google Scholar 

  16. Rogers RB, Yancey KB, Allen BS, Guill MF. Phenytoin therapy for junctional epidermolysis bullosa. Arch Dermatol 1983; 119:925–926.

    PubMed  CAS  Google Scholar 

  17. Guill MF, Wray BB, Rogers RB, Yancey KB, Allen BS. Junctional epidermolysis bullosa: treatment with phenytoin. Am J Dis Child. 1983; 137:992–994.

    PubMed  CAS  Google Scholar 

  18. Bergfeld WF, Orlowski JP. Epidermolysis bullosa letalis and phenytoin (letter). J Am Acad Dermatol 1982;7:275–276.

    PubMed  CAS  Google Scholar 

  19. Winer MN, Orman JM. Epidermolysis bullosa: a suggestion as to possible causation. Arch Dermatol Syphilol. 1945; 52:317–321.

    CAS  Google Scholar 

  20. Thompson RG, Leedham CL, Hailey H. Epidermolysis bullosa hereditaria. South Med J. 1949;42:647–653.

    PubMed  CAS  Google Scholar 

  21. Hall-Smith SP, Daunt FO’N. Recurrent bullous eruption of feet: report of a case. Lancet. 1948;1:66–67.

    PubMed  CAS  Google Scholar 

  22. Kumar K, Kumar R. Epidermolysis bullosa dystrophica et albo-papuloidea Pasini in an Indian: a case report. Dermatologica. 1973; 147:137–143.

    PubMed  CAS  Google Scholar 

  23. DesGrosseilliers J-P, Brisson P. Localized epidermolysis bullosa: report of two cases and evaluation of therapy with glutaraldehyde. Arch Dermatol. 1974; 109: 70–72.

    Google Scholar 

  24. Tkach JR. Treatment of recurrent bullous eruption of the hands and feet (Weber-Cockayne Disease) with topical aluminum chloride (letter). J Am Acad Dermatol. 1982;6:1095–1096.

    PubMed  CAS  Google Scholar 

  25. Jennings JL. Aluminum chloride hexahydrate treatment of localized epidermolyis bullosa. Arch Dermatol 1984; 120:1382.

    PubMed  CAS  Google Scholar 

  26. Younger IR, Priestley GC, Tidman MJ. Aluminum chloride hexahydrate and blistering in epidermolysis bullosa simplex. J Am Acad Dermatol. 1990; 23:930–931.

    PubMed  CAS  Google Scholar 

  27. Niemi K-M, Kero M, Kanerva L, Mattila R. Epidermolysis bullosa simplex: a new histologic subgroup. Arch Dermatol. 1983; 119:138–141.

    PubMed  CAS  Google Scholar 

  28. Rosset M. Epidermolysis bullosa in the newborn. Can Med Assoc J 1956; 75: 507–509.

    PubMed  CAS  Google Scholar 

  29. Silver HK. Epidermolysis bullosa hereditaria letalis: report of a case surviving for two and a half years. Arch Dis Child. 1957;32:216–219.

    PubMed  CAS  Google Scholar 

  30. Moynahan EJ. Epidermolysis bullosa affecting the buccal and pharyngeal mucosa. Proc R Soc Med. 1963; 56:885–888.

    PubMed  CAS  Google Scholar 

  31. Fattah AA. Epidermolysis bullosa hereditaria letalis (Herlitz). Dermatologica. 1966;133:475–481.

    PubMed  CAS  Google Scholar 

  32. Pearson RW, Potter B, Strauss F. Epidermolysis bullosa hereditaria letalis: clinical and histologic manifestations and course of the disease. Arch Dermatol. 1974;109:349–355.

    PubMed  CAS  Google Scholar 

  33. Schachner L, Lazarus GS, Dembitzer H. Epidermolysis bullosa hereditaria letalis: pathology, natural history and therapy. Br J Dermatol. 1977;96:51–58.

    PubMed  CAS  Google Scholar 

  34. Walther T. Epidermolysis bullosa hereditaria letalis: a review and report of two own cases. Ann Ped Int Rev Pediatr. 1953; 180:382–392.

    CAS  Google Scholar 

  35. Leland LS, Hirschl D. Epidermolysis bullosa hereditaria letalis in newborn twins: report of two cases with failure to respond favourably to cortisone. Am J Dis Child. 1954;87:321–327.

    CAS  Google Scholar 

  36. Henderson AT. Epidermolysis bullosa hereditaria letalis: report of a case failing to respond to cortisone. J Pediatr. 1955;46:186–191.

    PubMed  CAS  Google Scholar 

  37. Roberts MH, Howell DRS, Bramhall JL, Reubner B. Epidermolysis bullosa letalis: report of three cases with particular reference to the histopathology of the skin. Pediatrics. 1960;25:283–290.

    PubMed  CAS  Google Scholar 

  38. Lowe LB. Hereditary epidermolysis bullosa. Arch Dermatol. 1967;95:587–595.

    PubMed  Google Scholar 

  39. Bergenholtz A, Olsson O. Epidermolysis bullosa hereditaria letalis: a survey of the literature and report of 11 cases. Acta Derm Venereol (Stockh). 1968; 48: 220–241.

    CAS  Google Scholar 

  40. Oakley CA, Wilson N, Ross JA., Barnmetson RStC. Junctional epidermolysis bullosa in two siblings: clinical observations, collagen studies and electron microscopy. Br J Dermatol. 1984; 111:533–543.

    PubMed  CAS  Google Scholar 

  41. Gill S. Epidermolysis bullosa dystrophica with peculiar mutilation of hands. Israel Med J. 1961;20:11–12.

    Google Scholar 

  42. Taft EH. Dystrophic epidermolysis bullosa. Austr. J. Dermatol. 1969; 10:189–190.

    CAS  Google Scholar 

  43. Tidman MJ, Marsden RA. Severe dominant dystrophic epidermolysis bullosa. Br J Dermatol. 1985; 113(Suppl 29): 80–81.

    Google Scholar 

  44. Drury RE, Prieto Jr A. Epidermolysis bullosa dystrophica. Report of two cases within a family group. Oral Surg Oral Med Oral Pathol. 1964; 18:544–551.

    PubMed  CAS  Google Scholar 

  45. Caldiera Jde B, Costa MHL. Epidermolysis bullosa hereditaria: clinical trial with fluocinonide FAPG 0.05% in five cases. Acta Derm Venereol (Stockh). 1972; Suppl 67:88–90.

    Google Scholar 

  46. Enell H, Lindeas K. Epidermolysis bullosa hereditaria dystrofica. I. Treatment with cortisone. Acta Derm Venereol (Stockh). 1953;33:488–496.

    CAS  Google Scholar 

  47. Katz J, Gryboski JD, Rosenbaum HM, Spiro HM. Dysphagia in children with epidermolysis bullosa. Gastroenterology. 1967;52:259–262.

    PubMed  CAS  Google Scholar 

  48. Moynahan EJ. The treatment and management of epidermolysis bullosa. Clin Exp Dermatol. 1982; 7:665–672.

    PubMed  CAS  Google Scholar 

  49. Koob TJ, Jeffrey JJ, Eisen AZ. Regulation of human skin collagenase activity by hydrocortisone and dexamethasone in organ culture. Biochem Biophys Res Commun. 1974;61:1083–1088.

    PubMed  CAS  Google Scholar 

  50. Severin GL, Farber EM. The management of epidermolysis bullosa in children: effective topical steroid treatment. Arch Dermatol. 1967;95:302–309.

    PubMed  CAS  Google Scholar 

  51. Wilson HD. Treatment of epidermolysis bullosa dystrophica by alpha tocopherol. Can Med Assoc J. 1964;90:1315–1316.

    PubMed  CAS  Google Scholar 

  52. Ayres Jr S, Mihan R. Pseudoxanthoma elasticum and epidermolysis bullosa: response to vitamin E (tocopherol). Cutis. 1969;5:287–294.

    Google Scholar 

  53. Ayres Jr S, Mihan R. Vitamin E (tocopherol): a reappraisal of its value in dermatoses of mesodermal tissues. Cutis. 1971;7:35–45.

    Google Scholar 

  54. Sehgal VN, Sanyal RK. Vitamin E therapy in dystrophic epidermolysis bullosa (letter). Arch Dermatol. 1972; 105:460.

    PubMed  CAS  Google Scholar 

  55. Sehgal VN, Vadiraj SN, Rege VL, Beohar PC. Dystrophic epidermolysis bullosa in a family: response to vitamin E (tocopherol). Dermatologica. 1972; 144:27–34.

    PubMed  CAS  Google Scholar 

  56. Michaelson JD, Schmidt JD, Dresden MH, Duncan C. Vitamin E treratment of epidermolysis bullosa. Changes in tissue collagenase levels. Arch Dermatol. 1974; 109:67–69.

    PubMed  CAS  Google Scholar 

  57. Bonnetblanc JM, Bouquier JJ. Response to pipamperone in case of epidermolysis bullosa herpetiformis. Lancet. 1986; 1:1327–1328.

    PubMed  CAS  Google Scholar 

  58. Kahn S, Trieger N. Epidermolysis bullosa hereditaria letalis: a case report with special emphasis on oral manifestations. J Oral Med. 1976; 31:32–35.

    PubMed  CAS  Google Scholar 

  59. Haber RM. Reply to the editor (letter). J Am Acad Dermatol. 1988; 18:142–143.

    Google Scholar 

  60. Unger WP, Nethercott JR. Epidermolysis bullosa dystrophica treated with vitamin E and oral corticosteroids. Can Med Assoc J. 1973; 108:1136–1138.

    PubMed  CAS  Google Scholar 

  61. Trent WG. Epidermolysis bullosa. Arch Dermatol. 1976; 112:256.

    PubMed  CAS  Google Scholar 

  62. Harper JI, Copeman PWM. Pretibial epidermolysis bullosa: the use of homograft skin dressings. Br J Dermatol. 1983; 109(Suppl 24): 60–62.

    Google Scholar 

  63. Ayres Jr S, Mihan R. Letter to the Editor. Dermatologica. 1973; 146:61.

    PubMed  Google Scholar 

  64. Ayres Jr S, Mihan R. Vitamin E treatment of dermolytic bullous dermatosis (letter). Arch Dermatol. 1974; 109:99.

    PubMed  Google Scholar 

  65. Ayres Jr S. Epidermolysis bullosa controlled by vitamin E. Int J Dermatol. 1986;25:670–671.

    PubMed  Google Scholar 

  66. Fine J-D. Reply to Dr. Ayres (letter). Int J Dermatol. 1986; 25:671.

    Google Scholar 

  67. Reed WB. Vitamin E treatment of dermolytic bullous dermatosis (letter). Arch Dermatol. 1975; 111:524.

    PubMed  CAS  Google Scholar 

  68. Smith EB, Michener W. Vitamin E treatment of dermolytic bullous dermatosis: a controlled study. Arch Dermatol. 1973; 108:254–256.

    PubMed  CAS  Google Scholar 

  69. Adams RH, Main RA, Marsden RA. A controlled study of vitamin E treatment in epidermolysis bullosa. Br J Dermatol. 1975;93(Suppl 11): 10.

    Google Scholar 

  70. Briggaman RA, Palier AS, Pessar A. Epidermolysis bullosa. In: Provost TT, Farmer ER, eds. Current Therapy in Dermatology. Philadelphia: BC Decker; 1985:70–75.

    Google Scholar 

  71. Shubailat G, Oumeish OY, Amr SS. Epidermolysis bullosa dystrophica triggered by sun exposure. Ann Plast Surg. 1983; 10:239–243.

    PubMed  CAS  Google Scholar 

  72. Baer TW. Epidermolysis bullosa hereditaria treated with antimalarials. Arch Dermatol. 1961;84:503–504.

    PubMed  CAS  Google Scholar 

  73. Marrero L, Enriquez S, Bolat I. Epidermolysis bullosa simplex. Arch Dermatol. 1962;86:163.

    Google Scholar 

  74. Dorsey CS. Dystrophic epidermolysis bullosa treated with chloroquine. Arch Dermatol. 1959; 79:122.

    Google Scholar 

  75. Bauer EA, Seltzer JL, Eisen AZ. Inhibition of collagen degradative enzymes by retinoic acid in vitro. J Am Acad Dermatol. 1982;6:603–607.

    PubMed  CAS  Google Scholar 

  76. Cooper TW, Tabas M, Bauer EA. Retinoic acid in recessive dystrophic epidermolysis bullosa: in vitro effects on collagenase and preliminary therapeutic trials. In: Saurat JH, eds. Retinoids: New Trends in Research and Therapy. New York: S. Karger, 1985:219–224.

    Google Scholar 

  77. Tabas M, Spraker MK. Report on the first national epidermolysis bullosa conference November 29 to December 1, 1984. Pediatr Dermatol. 1985;3:79–82.

    Google Scholar 

  78. Fritsch P, Klein G, Aubock J, Hintner H. Retinoid therapy of recessive dystrophic epidermolysis bullosa (letter). J Am Acad Dermatol. 1983;9:766–777.

    PubMed  CAS  Google Scholar 

  79. Bauer EA, Seltzer JL, Eisen AZ. Retinoic acid inhibition of collagenase and gelatinase expression in human skin fibroblast cultures. Evidence for a dual mechanism. J Invest Dermatol. 1983; 81:162–169.

    PubMed  CAS  Google Scholar 

  80. Adreano JM, Tomecki KJ. Epidermolysis bullosa simplex responding to isotretinoin (letter). Arch Dermatol. 1988; 124:1445–1446.

    Google Scholar 

  81. Tidman MJ, Wells RS, MacDonald DM. Epidermolysis bullosa simplex (Dowling-Meara). In: Wilkinson DS, Mascaro JM, Orfanos CE, Albers J, eds. Clinical Dermatology, The CMD Case Collection, World Congress of Dermatology. Stuttgart: Schattauer, 1987:16–17.

    Google Scholar 

  82. Crikelair GF, Hoehn RJ, Domonkos AN, Binkert B. Skin homografts in epidermolysis bullosa dystrophica: case report. Plast Reconstr Surg. 1970; 46:89–92.

    PubMed  CAS  Google Scholar 

  83. Furue M, Ando I, Inoue Y, Tamaki K, Oohara K, Kukita A. Pretibial epidermolysis bullosa; successful therapy with a skin graft. Arch Dermatol. 1986; 122: 310–313.

    PubMed  CAS  Google Scholar 

  84. Harper JI, Copeman PWM. Pretibial epidermolysis bullosa: the use of homograft skin dressings. Br J Dermatol. 1983; 109(Suppl 24): 60–62.

    Google Scholar 

  85. Rhymes Jr R, Hardin JC, Metts Jr D, Krantz R. Dystrophic epidermolysis bullosa: extra-articular ankylosis treated with oral skin grafts: report of a case. J Oral Surg Anesth Hosp D Serv. 1963; 21:63–67.

    Google Scholar 

  86. Skivolocki W, Harris BH, Boles Jr ET. A new method for skin grafting a burned patient who has epidermolysis bullosa. Plast Reconstr Surg. 1974; 53:355–357.

    PubMed  CAS  Google Scholar 

  87. Carter DM, Lin AN, Varghese MC, Caldwell D, Pratt L, Eisinger M. Treatment of junctionaol epidermolysis bullosa with epidermal autografts. J Am Acad Dermatol. 1987;17:246–259.

    PubMed  CAS  Google Scholar 

  88. Lin AN., Carter DM, Caldwell-Brown D. Wound healing and cultured epidermal autografts in epidermolysis bullosa. In: Priestley GC, Tidman MJ, Weiss JB, Eady RAJ, eds. Epidermolysis Bullosa: A Comprehensive Review of Classification, Management and Laboratory Studies. Crowthorne: Dystrophic Epidermolysis Bullosa Research Association; 1990:152–155.

    Google Scholar 

  89. McGuire J, Birchnall N, Cuono C, Moellmann G, Kuklinska E, Langdon R. Successful engraftment of allogeneic keratinocyte cultures in recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 1987; 88:506.

    Google Scholar 

  90. Schofield OMV, Cassella J-P, Navsaria HA, Leigh IM, Mayou BJ, Eady RAJ. Cultured keratinocyte allografts indystrophic epidermolysis bullosa: preliminary observations. Br J Dermatol. 1990; 123(Suppl 37): 66.

    Google Scholar 

  91. Brogden RN, Pinder RM, Sawyer PR, et al. Bufexamac: a review of its pharmacological properties and therapeutic efficacy in inflammatory dermatoses. Drugs. 1975;10:351–356.

    PubMed  CAS  Google Scholar 

  92. Fine J-D, Johnson L. Evaluation of the efficacy of topical bufexamac in epidermolysis bullosa simplex: a double-blind placebo-controlled crossover study, Arch Dermatol. 1988;124:1669–1672.

    PubMed  CAS  Google Scholar 

  93. Golub LM, McNamara TF, D’Angelo G, Greenwald RA, Ramamurthy NS. A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J Dent Res. 1987; 66:1310–1314.

    PubMed  CAS  Google Scholar 

  94. White JE. Minocycline for dystrophic epidermolysis bullosa (letter). Lancet. 1989;1:966.

    PubMed  CAS  Google Scholar 

  95. Keller L. Silver nitrate therapy in epidermolysis bullossa hereditaria of the newborn. J Pediatr. 1968;72:854–856.

    PubMed  CAS  Google Scholar 

  96. Husz S, Olah J, Korom I, Szekeres L, Kemeny E, Dobozy A. Cyclosporine for dystrophic epidermolysis bullosa (letter). Lancet. 1989;2:1393–1394.

    PubMed  CAS  Google Scholar 

  97. Crow LL, Finkle JP, Gammon WR, Woodley DT. Clearing of epidermolysis bullosa acquisita with cyclosporine. J Am Acad Dermatol. 1988; 19:937–942.

    PubMed  CAS  Google Scholar 

  98. Fine J-D, Tamura T, Johnson L. Blood vitamin and trace metal levels in epidermolysis bullosa. Arch Dermatol. 1989; 125:374–379.

    PubMed  CAS  Google Scholar 

  99. Cunningham-Rundles S, Bookman RS, Lin AN, Giardina PV, Hilgartner MW. Physiological and pharmacological effects of zinc on immune response Ann NY Acad Sci. 1990;587:113–122.

    PubMed  CAS  Google Scholar 

  100. Weismann K. Dystrophic epidermolysis bullosa treated unsuccesfully with oral zinc (letter). Arch Dermatol Res. 1985;277:404–405.

    PubMed  CAS  Google Scholar 

  101. Ikeda S, Manabe M, Muramatsu T, Takamori K, Ogawa H. Protease inhibitor therapy for recessive dystrophic epidermolysis bullosa: in vitro effect and clinical trial with camostat mesylate. J Am Acad Dermatol. 1988; 18:1246–1252.

    PubMed  CAS  Google Scholar 

  102. Hashimoto I, Katabira Y, Mitsuhashi Y, Nomura K, Hanada K. Treatment of epidermolysis bullosa with PUVA therapy. In: Orfanos CE, Stadler R, Gollnick H, eds. Dermatology in Five Continents: Proceedings of the XVII World Congress of Dermatology, Berlin, May 24–29, 1987. Berlin: Springer-Verlag; 1988:1173.

    Google Scholar 

  103. Matsuoka LY, Safai B. Resolution of epidermolysis bullosa following oophorohysterectomy (letter). J Am Acad Dermatol. 1980; 3:205–206.

    PubMed  CAS  Google Scholar 

  104. Zackheim HS. Failure of human growth hormone to benefit dystrophic epidermolysis bullosa (letter). Arch Dermatol. 1983; 119:537.

    PubMed  CAS  Google Scholar 

  105. Haber RM, Ramsay CA, Boxall LBH. Assessment of a treatment for epidermolysis bullosa (letter). Can Med Assoc J 1984; 131:10–14.

    PubMed  CAS  Google Scholar 

  106. Haber RM, Ramsay CA, Boxall LBH. Epidermolysis bullosa: assessment of a treatment regimen. Int J Dermatol. 1985; 24:324–328.

    PubMed  CAS  Google Scholar 

  107. Katz SI, Bauer EA, Lazarus GS, McGuire Jr JS, Briggaman RA, Sulica V. Mr. Kozak’s regime for epidermolysis bullosa (letter). J Am Acad Dermatol. 1983; 8: 565–566.

    Google Scholar 

Download references

Authors
  1. Andrew N. Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Martin Carter
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, New York, NY, 10021-6399, USA

    Andrew N. Lin M.D.  & D. Martin Carter M.D., Ph.D.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Lin, A.N., Carter, D.M. (1992). Medical and Surgical Treatment of the Skin in Epidermolysis Bullosa. In: Lin, A.N., Carter, D.M. (eds) Epidermolysis Bullosa. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2914-8_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-2914-8_22

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7717-0

  • Online ISBN: 978-1-4612-2914-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation