Ophthalmological Aspects of Epidermolysis Bullosa

  • Scott E. Brodie


Epidermolysis bullosa (EB) is known to affect virtually every epithelial structure in the body.1 The epithelial surfaces of the eyelids, conjunctiva, and cornea are vulnerable to the disease process, producing a spectrum of ocular difficulties ranging from mild irritation and corneal abrasion to severe scarring, which may cause permanent loss of vision.2 This chapter reviews the epithelial structures of the eye, and describes the common patterns of ocular injury seen in the various major subtypes of EB. Surgical and nonsurgical therapies are also discussed.


Ocular Surface Epidermolysis Bullosa Orbicularis Muscle Dystrophic Epidermolysis Bullosa Epidermolysis Bullosa Simplex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Lin AN and Carter DM, Epidermolysis bullosa: when the skin falls apart. J Pediatr. 1989;114:349–355.PubMedCrossRefGoogle Scholar
  2. 2.
    Gans LA, Eye lesions of epidermolysis bullosa. Arch Dermatol. 1988; 124:762–764.PubMedCrossRefGoogle Scholar
  3. 3.
    Aurora AL, Madhavan M, Rao S. Ocular changes in epidermolysis bullosa letalis. Am J Ophthalmol. 1975; 79:464–470.PubMedGoogle Scholar
  4. 4.
    Granek H, Baden HP. Corneal involvement in epidermolysis bullosa simplex. Arch Ophthalmol. 1980; 98:469–472.PubMedGoogle Scholar
  5. 5.
    Tabas M, Gibbons 5, and Bauer EA. The mechanobullous diseases. Dermatol Clin. 1987;5:123–136.PubMedCrossRefGoogle Scholar
  6. 6.
    McDonnell PJ, Spalton DJ. The ocular signs and complications of epidermolysis bullosa. J R Soc Med. 1988; 81:576–578.PubMedGoogle Scholar
  7. 7.
    Hill JC, Rodrigue D. Cicatricial ectropion in epidermolysis bullosa and in congenital icthyosis: its plastic repair. Can J Ophthalmol. 1971;6:89–97.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Scott E. Brodie

There are no affiliations available

Personalised recommendations