Abstract
The ideal initial requirement for any clinical studies with medications to modify alcohol consumption is that there is extensive pre-clinical pharmacology with the compounds. At a minimum there should be sufficient evidence to suggest that the medication modifies ethanol self–administration, discriminative stimulus properties, place preference, development of tolerance or alcohol withdrawal or withdrawal behaviours (Bozarth, 1987). Despite the existence of reliable methods for conducting such studies, there are no current medications under study where there has been more than fragmentary pre–clinical information.
The views expressed in this manuscript are those of the authors and do not necessarily reflect thsoe of the Addiction Research Foundation.
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© 1992 Springer-Verlag New York, Inc.
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Sellers, E.M., Sobell, M.B. (1992). Medications for Alcohol Abuse and Dependence: Methodology for Clinical Studies. In: Naranjo, C.A., Sellers, E.M. (eds) Novel Pharmacological Interventions for Alcoholism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2878-3_3
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DOI: https://doi.org/10.1007/978-1-4612-2878-3_3
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