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Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal

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Novel Pharmacological Interventions for Alcoholism

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Abstract

The genesis of alcohol physical dependence is usually viewed as a consequence of adaptive mechanisms within the central nervous system. In this scheme alcohol produces inhibitory effects on neurones by some mechanism and this evokes an opposing adaptation in these neurones. Removal of alcohol once neurones have adapted in this way exposes this adaptation which causes the hyperexcitability of the alcohol withdrawal syndrome.

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Authors
  1. J. M. Littleton
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  2. O. Bouchenafa
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Editor information

Editors and Affiliations

  1. Addiction Research Foundation, M5S 2S1, Toronto, Ontario, Canada

    Claudio A. Naranjo  & Edward M. Sellers  & 

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© 1992 Springer-Verlag New York, Inc.

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Littleton, J.M., Bouchenafa, O. (1992). Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal. In: Naranjo, C.A., Sellers, E.M. (eds) Novel Pharmacological Interventions for Alcoholism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2878-3_15

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  • DOI: https://doi.org/10.1007/978-1-4612-2878-3_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7705-7

  • Online ISBN: 978-1-4612-2878-3

  • eBook Packages: Springer Book Archive

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