Vitreous and Retinopathy of Prematurity: Vitreous Surgery and Visual Results
Retinopathy of prematurity (ROP) is a unique retinal vascular disease because it appears during the development of the normal retinal vasculature and vitreous. It has been suggested that the avascular peripheral retina produces a vasoproliferative factor, which then affects tissue posterior to the retinal ridge (at the juncture of avascular and vascularized retina). This vasoproliferative factor then stimulates neovascularization only in that location. We were curious as to why neovascularization is seen only in the area posterior to the ridge and is not seen at the optic nerve head or in areas anterior yet adjacent to the ridge. We have examined enucleated human eyes at autopsy, as well as animal eyes derived from the Ashton kitten model of ROP, and found that the vitreous is intimately attached to the neurosensory retina posterior to the retinal ridge. Anterior to the retinal ridge, this attachment does not seem to be as strong, as seen by either morphologic or immunohistochemical techniques.
KeywordsRetina Fibril Cane Blindness Shoe
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