Vitreous and Retinopathy of Prematurity: Vitreous Surgery and Visual Results
Retinopathy of prematurity (ROP) is a unique retinal vascular disease because it appears during the development of the normal retinal vasculature and vitreous. It has been suggested that the avascular peripheral retina produces a vasoproliferative factor, which then affects tissue posterior to the retinal ridge (at the juncture of avascular and vascularized retina). This vasoproliferative factor then stimulates neovascularization only in that location. We were curious as to why neovascularization is seen only in the area posterior to the ridge and is not seen at the optic nerve head or in areas anterior yet adjacent to the ridge. We have examined enucleated human eyes at autopsy, as well as animal eyes derived from the Ashton kitten model of ROP, and found that the vitreous is intimately attached to the neurosensory retina posterior to the retinal ridge. Anterior to the retinal ridge, this attachment does not seem to be as strong, as seen by either morphologic or immunohistochemical techniques.
KeywordsRetinal Detachment Scleral Buckling Vitreous Surgery Vitreous Traction Avascular Retina
Unable to display preview. Download preview PDF.
- 2.Hartzer W. Trese MT, et al. ARVO 1988.Google Scholar
- 3.Garfinkel RA, Trese MT. Spontaneous resolution of retinal detachment in retinopathy of prematurity. Am J Ophthalmol Submitted for publication.Google Scholar
- 4.Charles S. Vitreous surgery for retinopathy of prematurity (ROP) In: Syllabus: Retinopathy of Prematurity Conference, Washington, DC, 1981: 858–863.Google Scholar
- 9.Mayer DL, Trese MT. Visual function evaluation of patients with retinopathy of prematurity noninvasive assessment of the visual system. Presented to the Optical Society of America Topical Meeting, Lake Tahoe, 1990.Google Scholar
- 10.Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity Arch Ophthalmol 1988; 106: 471–479.Google Scholar
- 12.Birch EE, Spencer R. Invest Ophthalmol 1989; 30 (suppl): 318.Google Scholar
- 13.Dobson V. et al. Submitted for publication.Google Scholar
- 16.Droste PJ, Invest Ophthalmol 1987; 28 (suppl) 154.Google Scholar