Skip to main content
SpringerLink
Log in

Atlas of Hepatic Arterial Perfusion Scintigraphy

  • Chapter
Selected Atlases of Gastrointestinal Scintigraphy

Part of the book series: Atlases of Clinical Nuclear Medicine ((ATLASES))

  • 79 Accesses

Abstract

Colorectal carcinoma is the third most common cancer in the United States, accounting for 15% of malignancies. The liver is the most common site of metastasis. Approximately 25% of patients have hepatic metastases at the time of presentation and two-thirds eventually develop them. The presence of hepatic metastases has a major influence on prognosis. Survival in untreated patients with colorectal cancer metastatic to the liver varies from 1 to 22 months and is a function of the extent of hepatic disease at the time of presentation.1 Complete surgical resection of liver metastases is the only curative therapy but is feasible for only a few patients who have solitary or unilobar metastasis. Conventional intravenous bolus chemotherapy (e.g., 5-fluorouracil) yields response rates of only 10% to 30%.2

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Stagg RJ, Lewis BJ, Friedman MA, Ignoffo RJ, Hohn DC. Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver. Ann Intern Med. 1984;100:736–743.

    PubMed  CAS  Google Scholar 

  2. Moertel CG. Clinical management of advanced gastroinestinal cancer. Cancer. 1975;36:675–682.

    Article  PubMed  CAS  Google Scholar 

  3. Sullivan RD, Norcross JW, Watkins E Jr. Chemotherapy of metastatic liver cancer by prolonged hepatic-artery infusion. N Engl J Med. 1964;270:321–327.

    Article  PubMed  CAS  Google Scholar 

  4. Brennan MJ, Talley RW, Drake EH, et al. 5-Fluorouracil treatment of liver metastases by continuous hepatic artery infusion via Cournand catheter. Ann Surg. 1963;158:405–419.

    PubMed  CAS  Google Scholar 

  5. Clarkson B, Young C, Dierick W, et al. Effects of continuous hepatic artery infusion of antimetabolites on primary and metastatic cancer of the liver. Cancer. 1962;15:472–488.

    Article  PubMed  CAS  Google Scholar 

  6. Oberfield RA. Intraarterial hepatic infusion chemotherapy in metastatic liver cancer. Semin Oncol. 1983;10:206–214.

    PubMed  CAS  Google Scholar 

  7. Patt YZ, Mavligit GM, Chuang VP. Percutaneous hepatic arterial infusion of mitomycin C and Floxuridine (FUDR): an effective treatment for metastatic colorectal carcinoma in the liver. Cancer. 1980;46:261–265.

    Article  PubMed  CAS  Google Scholar 

  8. Chuang VP, Wallace S. Interventional approaches to hepatic tumor treatment. Semin Roentgenol. 1983;XVIII:127–135.

    Article  Google Scholar 

  9. Cohen AM, Greefield A, Wood WC, et al. Treatment of hepatic metastases by transaxillary hepatic artery chemotherapy using an implanted drug pump. Cancer. 1983;51:2013–2019.

    Article  PubMed  CAS  Google Scholar 

  10. Niederhuber JE, Ensminger WD. Surgical considerations in the management of hepatic neoplasia. Semin Oncol. 1983;10:135–147.

    PubMed  CAS  Google Scholar 

  11. Ensminger W, Niederhuber J, Dakhil S, Thrall J, Wheeler R. Totally implanted drug delivery system for hepatic arterial chemotherapy. Cancer Treat Rep. 1981;65:393–400.

    PubMed  CAS  Google Scholar 

  12. Kaplan WD, D’Orsi CJ, Ensminger WD, Smith EH, Levin DC. Intra-arterial radionuclide infusion: a new technique to assess chemotherapy perfusion patterns. Cancer Treat Rep. 1978;62:699–703.

    PubMed  CAS  Google Scholar 

  13. Borzutsky CA, Turbiner EH. The predictive value of hepatic artery perfusion scintigraphy. J Nucl Med. 1985;26:1153–1156.

    Google Scholar 

  14. Kaplan WD, Ensminger WD, Come SE, et al. Radionuclide angiograpy to predict patient response to hepatic artery chemotherapy. Cancer Treat Rep. 1980;64:1217–1222.

    PubMed  CAS  Google Scholar 

  15. Ziessman HA, Thrall JH, Yang PJ, et al. Hepatic arterial perfusion scintigraphy with Tc-99m MAA. Radiology. 1984;152:167–172.

    PubMed  CAS  Google Scholar 

  16. Gotti EW. Microsphere angiography of the liver. J Nucl Med. 1978;19:433–434.

    PubMed  CAS  Google Scholar 

  17. Yang PJ, Thrall JH, Ensminger WD, et al. Perfusion scintigraphy (Tc-99m MAA) during surgery for placement of chemotherapy catheter in hepatic artery: concise communication. J Nucl Med. 1982;23:1066–1069.

    PubMed  CAS  Google Scholar 

  18. Bledin AG, Kim EE, Chuang VP, Wallace S, Haynie TP. Changes of arterial blood flow patterns during infusion chemotherapy, as monitored by intraarterially injected technetium-99m macroaggregated albumin. Br J Radiol. 1984;57:197–203.

    Article  PubMed  CAS  Google Scholar 

  19. Clouse ME, Ryan AR, Oberfield RA, McCaffrey JA. Complications of long-term transbrachial hepatic arterial infusion chemotherapy. AJR. 1911; 129:799–803.

    Google Scholar 

  20. Kemeny N, Cohen A, Bertino JR, et al. Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma. Cancer. 1989;65:2446–2450.

    Article  Google Scholar 

  21. Kemeny N, Daly J, Reichman B, et al. Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. Ann Intern Med. 1987;107:459–465.

    PubMed  CAS  Google Scholar 

  22. Hohn D, Stagg R, Friedman M, et al. The NCOG randomized trial of intravenous vs hepatic arterial FUDR for colorectal cancer metastatic to the liver. Proc Am Soc Clin Oncol. 1987;6:85. Abstract.

    Google Scholar 

  23. Kemeny N, Goldberg D, Beatty JD, et al. Results of a prospective randomized trial of continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal primaries. Cancer. 1968; 57:492–498.

    Article  Google Scholar 

  24. O’Connell M, Mailliard J, Martin J, et al. A controlled trial of regional intra-arterial FUDR versus systemic 5 FU for the treatment of metastatic colorectal cancer confined to the liver. Proc Am Soc Clin Oncol. 1989;8:98. Abstract.

    Google Scholar 

  25. Safi F, Bittner R, Roscher R, et al. Regional chemotherapy for hepatic metastases of colorectal carcinoma (continuous intra-arterial versus continuous intraarterial/intravenous therapy). Cancer. 1989;64:379–387.

    Article  PubMed  CAS  Google Scholar 

  26. Chen H-S, Gross JF. Intra-arterial infusion of anticancer drugs: theoretic aspects of drug delivery and review of responses. Cancer Treat Rep. 1980; 64:31–40.

    PubMed  CAS  Google Scholar 

  27. Ensminger WE, Gyves JW. Clinical pharmacology of hepatic arterial chemotherapy. Semin Oncol. 1983;10:176–181.

    PubMed  CAS  Google Scholar 

  28. Dakhil S, Ensminger WD, Cho K, et al. Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer. 1982;50:631–635.

    Article  PubMed  CAS  Google Scholar 

  29. Ziessman HA, Thrall JH, Gyves JW, et al. Quantitative hepatic arterial perfusion scintigraphy and starch microspheres in cancer chemotherapy. J Nucl Med. 1983;24:871–875.

    PubMed  CAS  Google Scholar 

  30. Zlotecki R, Gyves J, Ensminger W. Epinephrine induced shunting of blood flow to rabbit hepatic VX-2 implants. Proc Am Assoc Cancer Res. 1985;26: 1392.

    Google Scholar 

  31. Ziessman HA, Forastiere Wheeler RH, et al. The use of a vasoconstrictor to improve the tumor to non-tumor blood flow ratio in intraarterial chemotherapy of head and neck cancer: work in progress. Nucl Med Commun. 1985;6:777–786.

    Article  PubMed  CAS  Google Scholar 

  32. Ziessman HA, Gyves JW, Juni JE, et al. Atlas of hepatic arterial perfusion scintigraphy. Clin Nucl Med. 1985;10:675–681.

    Article  PubMed  CAS  Google Scholar 

  33. Noguchi S, Miyauchi K, Nishizawa Y, et al. Augmentation of anticancer effect with angiotensin II in intraarterial infusion chemotherapy for breast carcinoma. Cancer. 1988;62:467–473.

    Article  PubMed  CAS  Google Scholar 

  34. Wollner IS, Knutsen CA, Ullrich KA, et al. Effects of hepatic arterial yttrium-90 microsphere administration alone and combined with regional bromodeoxyuridine infusion in dogs. Cancer Res. 1987;47:3285–3290.

    PubMed  CAS  Google Scholar 

  35. Houle S, Yip T-CK, Shepherd FA, et al. Hepatocellular carcinoma: pilot trial of treatment with Y-90 microspheres. Radiology. 1989;172: 857–860.

    PubMed  CAS  Google Scholar 

  36. Wollner I, Knutson C, Smith P, et al. Effects of hepatic arterial yttrium-90 glass micropsheres in dogs. Cancer. 1988;61:1336–1344.

    Article  PubMed  CAS  Google Scholar 

  37. Shibata J, Fujiyama S, Sato T, et al. Hepatic arterial injection chemotherapy with cisplatin suspended in an oily lympographic agent for hepatocellular carcinoma. Cancer. 1989;64:1586–1594.

    Article  PubMed  CAS  Google Scholar 

  38. Sasaki Y, Imaoka S, Kasugai H, et al. A new approach to chemoembolization therapy for hepatoma using ethiodized oil, cisplatin, and gelatin sponge. Cancer. 1987;60:1194–1203.

    Article  PubMed  CAS  Google Scholar 

  39. Wahl RL, Ziessman HA, Juni J, Lahti D. Gastric air contrast: useful adjunct to hepatic artery scintigraphy. Am J Roentgenol. 1984;143:321–325.

    CAS  Google Scholar 

  40. Croft BY. Radiation dose estimates for the arterial injection of Tc-99m labeled HS A microspheres and macroaggregated particles. In: Schlafke-Stelson AT, Watson EE, eds. Proceedings of the Fourth International Radiopharmaceutical Dosimetry Symposium. Oak Ridge, Tenn: U.S. Dept. of Energy and Oak Ridge Associated Universities; 1986:260–266.

    Google Scholar 

  41. Thrall JH. Hepatic artery perfusion study. In: Carey JE, Kline RC, Keyes JW Jr, eds. Manual of Nuclear Medicine Procedures. 4th ed. Boca Raton, Fla: CRC Press; 1983:97–99.

    Google Scholar 

  42. Michels NA. Newer antomy of the liver and its variant blood supply and collateral circulation. Am J Surg. 1966;112:337–347.

    Article  PubMed  CAS  Google Scholar 

  43. Chuang VP. Hepatic tumor angiography: a subject review. Radiology. 1983; 148:633–639.

    PubMed  CAS  Google Scholar 

  44. Kaplan WD, Come SE, Takuorian RW, et al. Pulmonary uptake of technetium-99m macroaggregated albumin: a predictor of gastrointestinal toxicity during hepatic artery perfusion. J Clin Oncol. 1984;2:1266–1269.

    PubMed  CAS  Google Scholar 

  45. Ziessman HA, Wahl RL, Juni JE, et al. The utility of SPECT for hepatic arterial perfusion scintigraphy. Am J Roentgenol. 1985;145:747–751.

    CAS  Google Scholar 

  46. Gyves JW, Ziessman HA, Ensminger WD, et al. Definition of hepatic tumor microcirculation by single photon emission computed tomography (SPECT). J Nucl Med. 1984;25:972–977.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Harvey A. Ziessman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Nuclear Medicine, Georgetown University Hospital, Washington, DC, 20007, USA

    Harvey A. Ziessman MD (Associate Professor of Radiology) (Associate Professor of Radiology)

  2. Nuclear Medicine Department, Good Samaritan Hospital, Baltimore, MD, 21239, USA

    Douglas Van Nostrand MD (Director and Clinical Professor of Radiology and Nuclear Medicine) (Director and Clinical Professor of Radiology and Nuclear Medicine)

  3. Uniformed Services University of Health Sciences, Bethesda, MD, 20814, USA

    Douglas Van Nostrand MD (Director and Clinical Professor of Radiology and Nuclear Medicine) (Director and Clinical Professor of Radiology and Nuclear Medicine)

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Ziessman, H.A. (1992). Atlas of Hepatic Arterial Perfusion Scintigraphy. In: Ziessman, H.A., Van Nostrand, D. (eds) Selected Atlases of Gastrointestinal Scintigraphy. Atlases of Clinical Nuclear Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2794-6_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-2794-6_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7673-9

  • Online ISBN: 978-1-4612-2794-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation